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Med Rx.

Amlodipine Besilate + Telmisartan + Vericiguat

Moderate 4 published sources

This interaction is documented in this data source.

Amlodipine Besilate + Telmisartan
Checked as Amlodipine + Telmisartan
Vericiguat
Checked as Vericiguat

2 documented mechanisms

This source documents more than one distinct mechanism for this pair. Each is shown with its own effect, advice and sources rather than merged into one.

  1. Mechanism 1: Synergy

    Moderate

    via Telmisartan and Vericiguat

    What happens

    Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension, especially in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or patients with a history of hypotension.

    What to do

    If patients experience tolerability issues (symptomatic hypotension or SBP less than 90 mmHg), temporary down-titration or discontinuation of vericiguat is recommended.

    2 sources

    1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
    2. "Product Information. Verquvo (vericiguat)." Merck & Co., Inc (2021):

  2. Mechanism 2: Synergy

    Moderate

    via Amlodipine and Vericiguat

    What happens

    Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension, especially in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or patients with a history of hypotension.

    What to do

    If patients experience tolerability issues (symptomatic hypotension or SBP less than 90 mmHg), temporary down-titration or discontinuation of vericiguat is recommended.

    2 sources

    1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
    2. "Product Information. Verquvo (vericiguat)." Merck & Co., Inc (2021):

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