Carbonyl Iron + Folic Acid + Zinc Sulfate + Vitamin B Complex + Vitamin C interactions

Checked as Iron + Folic acid + Zinc sulfate in this data source.

Full monograph for Carbonyl Iron + Folic Acid + Zinc Sulfate + Vitamin B Complex + Vitamin C Check it against another medicine

Medicines

600 documented

Severity

Mechanism

Medicines documented to interact with Carbonyl Iron + Folic Acid + Zinc Sulfate + Vitamin B Complex + Vitamin C, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Capecitabinevia Folic acid	Major	Synergy	Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU). The exact mechanism of interaction is unknown. Although…	9 sources — open the full entry
Fluorouracilvia Folic acid	Major	Synergy	Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU). The exact mechanism of interaction is unknown. Although…	9 sources — open the full entry
Alendronic acidvia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms	9 sources — open the full entry
Alendronic Acid + Vitamin D3via Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms	9 sources — open the full entry
Aluminium Hydroxide + Magnesium Hydroxidevia Iron	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Aluminium Hydroxide + Magnesium Hydroxide + Simethiconevia Iron	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Aluminium Oxide + Magnesium Trisilicatevia Iron	Moderate	Absorption	The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The…	12 sources — open the full entry
Baloxavir Marboxilvia Zinc sulfate, Iron	Moderate	Absorption	Coadministration with polyvalent cation-containing products may decrease the plasma concentrations and therapeutic efficacy of baloxavir. The proposed…2 documented mechanisms	3 sources — open the full entry
Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocainevia Iron, Folic acid	Moderate	Antagonism · Unknown	Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…4 documented mechanisms	3 sources — open the full entry
Beta carotene + Vitamin C + Vitamin Evia Iron	Moderate	Antagonism	Limited data suggest that vitamin E may diminish the therapeutic response to iron therapy in patients with iron deficiency anemia.	2 sources — open the full entry
Calcium acetate + Magnesium carbonatevia Iron	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…	12 sources — open the full entry
Calcium Carbonatevia Iron	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…	12 sources — open the full entry
Calcium Lactate Gluconate + Calcium Carbonate + Vitamin Cvia Iron	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…	12 sources — open the full entry
Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C + Vitamin D3via Iron	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…	12 sources — open the full entry
Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3via Iron	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…	12 sources — open the full entry
Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3 + Multimineralsvia Iron	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…	12 sources — open the full entry
Carbamazepinevia Folic acid	Moderate	Antagonism	Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair…	26 sources — open the full entry
Carbidopa + LevodopaExtended release Prolonged releasevia Iron	Moderate	Absorption	INTERVAL: The oral bioavailability and pharmacologic effects of levodopa and carbidopa may be decreased during concurrent administration with iron-containing…	5 sources — open the full entry
Cefdinirvia Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: The oral bioavailability of cefdinir may be significantly decreased by concomitant administration of iron preparations. The proposed mechanism is…2 documented mechanisms	2 sources — open the full entry
Ceftibuten Dihydratevia Zinc sulfate	Moderate	Absorption	Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or…	3 sources — open the full entry
Cephalexinvia Zinc sulfate, Folic acid	Moderate	Absorption · Unknown	Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or…2 documented mechanisms	3 sources — open the full entry
Cephradinevia Zinc sulfate	Moderate	Absorption	Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or…	3 sources — open the full entry
Chloramphenicol (Oral)via Iron, Folic acid	Moderate	Antagonism · Unknown	Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…2 documented mechanisms	3 sources — open the full entry
Chloramphenicol + Lidocaine Hydrochloridevia Iron, Folic acid	Moderate	Antagonism · Unknown	Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…3 documented mechanisms	3 sources — open the full entry
Ciprofloxacinbase Ophthalmicvia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…3 documented mechanisms	32 sources — open the full entry
Ciprofloxacin + Dexamethasonevia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Antagonism · Unknown	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…5 documented mechanisms	36 sources — open the full entry
Ciprofloxacin + Hydrocortisone Acetatevia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…3 documented mechanisms	32 sources — open the full entry
Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafinevia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…5 documented mechanisms	32 sources — open the full entry
Deferipronevia Zinc sulfate, Iron	Moderate	Absorption	INTERVAL: Deferiprone has the potential to bind polyvalent cations such as aluminum, iron and zinc, which may reduce its effectiveness. However, concurrent use…2 documented mechanisms	1 sources — open the full entry
Delafloxacinvia Zinc sulfate, Iron	Moderate	Absorption	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…2 documented mechanisms	32 sources — open the full entry
Dexamethasone + Chloramphenicolvia Zinc sulfate, Iron, Folic acid	Moderate	Antagonism · Unknown	Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…4 documented mechanisms	7 sources — open the full entry
Dexamethasone + Levofloxacinvia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Antagonism · Unknown	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…4 documented mechanisms	36 sources — open the full entry
Dexlansoprazolevia Iron	Moderate	Absorption	The profound hypochlorhydria induced by proton pump inhibitors (PPIs) may impair the gastrointestinal absorption of nonheme iron, a process that is dependent…	12 sources — open the full entry
Doxycycline Hydrochloridevia Iron, Folic acid	Moderate	Absorption · Unknown	The bioavailability of oral tetracyclines and iron salts may be significantly decreased during concurrent administration. Therapeutic failure may result. The…2 documented mechanisms	14 sources — open the full entry
Eltrombopag Olaminevia Zinc sulfate, Iron	Moderate	Absorption	INTERVAL: Products containing aluminum, calcium, iron, magnesium, zinc and other polyvalent cations such as antacids or mineral supplements can significantly…2 documented mechanisms	4 sources — open the full entry
Esomeprazolebase MUPS preparationvia Iron	Moderate	Absorption	The profound hypochlorhydria induced by proton pump inhibitors (PPIs) may impair the gastrointestinal absorption of nonheme iron, a process that is dependent…	12 sources — open the full entry
Esomeprazole + Amoxicillin + Clarithromycinvia Iron, Folic acid	Moderate	Absorption · Unknown	The profound hypochlorhydria induced by proton pump inhibitors (PPIs) may impair the gastrointestinal absorption of nonheme iron, a process that is dependent…3 documented mechanisms	12 sources — open the full entry
Ethosuximidevia Folic acid	Moderate	Antagonism	Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair…	26 sources — open the full entry
Ferric Carboxymaltosevia Iron	Moderate	Absorption	Parenteral iron therapy may reduce the absorption of concomitantly administered oral iron preparations.	4 sources — open the full entry
Ferric Derisomaltosevia Iron	Moderate	Absorption	Parenteral iron therapy may reduce the absorption of concomitantly administered oral iron preparations.	4 sources — open the full entry
Ferric Pyrophosphate Citratevia Iron	Moderate	Absorption	Parenteral iron therapy may reduce the absorption of concomitantly administered oral iron preparations.	5 sources — open the full entry
Fosphenytoin Sodiumvia Folic acid	Moderate	Antagonism	Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair…	26 sources — open the full entry
Gatifloxacinvia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…3 documented mechanisms	32 sources — open the full entry
Gatifloxacin + Dexamethasonevia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Antagonism · Unknown	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…5 documented mechanisms	36 sources — open the full entry
Gemifloxacinvia Zinc sulfate, Iron	Moderate	Absorption	INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…2 documented mechanisms	32 sources — open the full entry
Ibandronic Acidvia Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms	9 sources — open the full entry
Ibandronic Acid + Algae Calcium + Vitamin D3via Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms	9 sources — open the full entry
Ibandronic Acid + Coral Calcium + Vitamin D3via Zinc sulfate, Iron, Folic acid	Moderate	Absorption · Unknown	INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms	9 sources — open the full entry
Iron Sucrosevia Iron	Moderate	Absorption	Parenteral iron therapy may reduce the absorption of concomitantly administered oral iron preparations.	4 sources — open the full entry
Lamotriginevia Folic acid	Moderate	Antagonism	Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair…	26 sources — open the full entry

Food & lifestyle

alcohol
Moderate
Synergy
Ethanol may increase folic acid elimination and folic acid absorption is decreased in chronic alcoholics. Excessive alcohol consumption may lead to folate deficiency.
What to do: Monitoring of patient response to folic acid supplementation if they also consume alcohol regularly may be recommended.
5 sources
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. Agencia Espa?ola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaci��n online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
4. Cerner Multum, Inc "ANVISA Bul��rio Eletr?nico." O 0 (2015):
5. "Product Information. Folic Acid (folic acid)." Method Pharmaceuticals, LLC (2017):
food
Moderate
Absorption
Concomitant use of some food may reduce the bioavailability of orally administered iron, and vice versa.
What to do: Ideally, iron products should be taken on an empty stomach (i.e., at least 1 hour before or 2 hours after meals), but if this is not possible, administer with meals and monitor the patient more closely for a subtherapeutic effect. Some studies suggest administration of iron with ascorbic acid may enhance bioavailability. In addition, administration of oral iron products and some oral medications should be separated whenever the bioavailability of either agent may be decreased. Consult the product labeling for specific separation times and monitor clinical responses as appropriate.
2 sources
1. "Product Information. Feosol (ferrous sulfate)." SmithKline Beecham
2. "Product Information. Accrufer (ferric maltol)." Shield Therapeutics (2021):

Conditions

Conditions in which Carbonyl Iron + Folic Acid + Zinc Sulfate + Vitamin B Complex + Vitamin C needs care, as documented in this source.

Anemia
Major
The use of folic acid is contraindicated in patients with undiagnosed anemia. Folic acid in dosages above 1 mg/day can obscure the diagnosis of pernicious anemia by alleviating the hematologic abnormalities while allowing the progression of neurologic complications. In addition, folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.
3 sources
1. Butterworth CE Jr, Tamura T "Folic acid safety and toxicity: a brief review." Am J Clin Nutr 50 (1989): 353-8
2. Katz M "Potential danger of self-medication with folic acid." N Engl J Med 289 (1973): 1095
3. "Product Information. Renal Multivitamin Formula Rx (folic acid)." Vitaline Corporation, Ashland, OR.
Kidney Diseases
Moderate
The trace metals, chromium and zinc, are excreted primarily in the urine. Selenium is partially excreted in the urine. Supplemental doses of these agents may need to be adjusted, reduced, or omitted in patients with renal dysfunction.
3 sources
1. "Product Information. Galzin (zinc acetate)." Teva Pharmaceuticals USA (2001):
2. "Product Information. Chroma-Pak (chromic chloride hexahydrate)." Apothecon Inc (2022):
3. "Product Information. Sele-Pak (selenium)." Fujisawa
Malabsorption Syndromes
Moderate
The trace metals manganese, chromium, copper, selenium, and zinc are absorbed in the GI tract from dietary sources and following administration of oral supplements. GI absorption may be decreased in patients with malabsorption syndromes. Therefore, larger dosages may be required when these supplements are given orally. Parenteral administration may be appropriate.
6 sources
1. "Product Information. Galzin (zinc acetate)." Teva Pharmaceuticals USA (2001):
2. "Product Information. Chroma-Pak (chromic chloride hexahydrate)." Apothecon Inc (2022):
3. "Product Information. Sele-Pak (selenium)." Fujisawa
4. "Product Information. Copper Sulfate (copper sulfate)." Humco Holding Group (2001):
5. "Product Information. Manganese Chloride (manganese chloride)." Abbott Pharmaceutical (2001):
6. "Product Information. Manganese Sulfate (manganese sulfate)." American Regent Laboratories Inc (2001):

Medicines

Food & lifestyle

alcohol

food

Conditions

Anemia

Kidney Diseases

Malabsorption Syndromes