Desloratadine interactions

Medicines

390 documented

Severity

Medicines documented to interact with Desloratadine, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
ErythromycinLotion Oral	Minor	Metabolism	Erythromycin and ketoconazole may increase the plasma concentrations of desloratadine and its metabolite. The probable mechanism is inhibition of CYP450…	1 sources — open the full entry
Ketoconazole	Minor	Metabolism	Erythromycin and ketoconazole may increase the plasma concentrations of desloratadine and its metabolite. The probable mechanism is inhibition of CYP450…	1 sources — open the full entry
Ketoconazole + Zinc Pyrithione + Aleovera	Minor	Metabolism	Erythromycin and ketoconazole may increase the plasma concentrations of desloratadine and its metabolite. The probable mechanism is inhibition of CYP450…	1 sources — open the full entry

Conditions in which Desloratadine needs care, as documented in this source.

Asthma
Moderate
Desloratadine products contain sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. Caution is advised when using these products in people with asthma.
1 source
1. "Product Information. Clarinex (desloratadine)." Schering Corporation (2002):
Liver Diseases
Moderate
Dosing adjustment of desloratadine is recommended for patients with renal or hepatic impairment. Dosing recommendations for children with liver or renal impairment cannot be made due to lack of data.
1 source
1. "Product Information. Clarinex (desloratadine)." Schering Corporation (2002):