Diazoxide interactions
Full monograph for DiazoxideCheck it against another medicine
Medicines
192 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Tizanidine Hydrochloride | Major | Synergy | Tizanidine may potentiate the hypotensive effect of some medications secondary to its alpha-2 adrenergic activity. Pharmacologic studies have found tizanidine… | 1 sources — open the full entry |
| Acarbose | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Acyclovir + Hydrocortisone | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Alogliptin Benzoate | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Alprazolam | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Amisulpride | Moderate | Synergy | Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking… | 11 sources — open the full entry |
| Amitriptyline Hydrochloride | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Amitriptyline Hydrochloride + Chlordiazepoxide | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 11 sources — open the full entry |
| Aripiprazole | Moderate | Synergy | Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking… | 11 sources — open the full entry |
| Asenapine Maleate | Moderate | Synergy | Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking… | 11 sources — open the full entry |
| Atenolol + Chlorthalidone | Moderate | Synergy | The combination of thiazide diuretics and diazoxide may result in profound and prolonged hyperglycemia. The mechanism may be related to additive hyperglycemic… | 1 sources — open the full entry |
| Avanafil | Moderate | Synergy | Phosphodiesterase-5 (PDE5) inhibitors may potentiate the blood pressure-lowering effect of antihypertensive medications. These agents inhibit PDE5-mediated… | 4 sources — open the full entry |
| Azilsartan Medoxomil + Chlorthalidone | Moderate | Synergy | The combination of thiazide diuretics and diazoxide may result in profound and prolonged hyperglycemia. The mechanism may be related to additive hyperglycemic… | 1 sources — open the full entry |
| Baclofen | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Betamethasone | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone + Calcipotriol | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone + Clotrimazole | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone + Neomycin Sulphate (Ophthalmic) | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone + Phenylephrine + Lignocaine | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone Dipropionate | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone Dipropionate + Salicylic Acid | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone Sodium Phosphate | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Betamethasone Valerate | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Biphasic Insulin Aspart | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Bisoprolol Fumarate + Hydrochlorothiazide | Moderate | Synergy | The combination of thiazide diuretics and diazoxide may result in profound and prolonged hyperglycemia. The mechanism may be related to additive hyperglycemic… | 1 sources — open the full entry |
| Brexpiprazole | Moderate | Synergy | Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking… | 11 sources — open the full entry |
| BudesonideInhalerNebuliser SuspensionTablet | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Budesonide + Formoterol Fumarate | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Budesonide + Glycopyrronium Bromide + Formoterol Fumarate | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Bupropion Hydrochloride | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Cabergoline | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Calcium Dobesilate + Lidocaine + Dexamethasone | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Canagliflozin Hemihydrate | Moderate | Synergy | Sodium-glucose co-transporter 2 (SGLT-2) inhibitors may potentiate the hypotensive effects of diuretics and other antihypertensive agents or vasodilators… | 15 sources — open the full entry |
| Candesartan Cilexetil + Hydrochlorothiazide | Moderate | Synergy | The combination of thiazide diuretics and diazoxide may result in profound and prolonged hyperglycemia. The mechanism may be related to additive hyperglycemic… | 1 sources — open the full entry |
| Carbidopa + LevodopaExtended releaseProlonged release | Moderate | Synergy | The hypotensive effects of levodopa and antihypertensive agents may be additive. Postural hypotension may occur. | 11 sources — open the full entry |
| Cariprazine | Moderate | Synergy | Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking… | 11 sources — open the full entry |
| Carisoprodol | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Chloral Hydrate | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Chlorpromazine Hydrochloride | Moderate | Synergy | Anecdotal information suggests that chlorpromazine may increase the hyperglycemic effect of diazoxide through an unknown mechanism. Both agents individually… | 1 sources — open the full entry |
| Chlorthalidone | Moderate | Synergy | The combination of thiazide diuretics and diazoxide may result in profound and prolonged hyperglycemia. The mechanism may be related to additive hyperglycemic… | 1 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Framycetin + Esculin | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Neomycin + Esculin | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Cinnarizine + Dimenhydrinate | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Ciprofloxacin + Dexamethasone | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Clobazam | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Clomipramine Hydrochloride | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Clonazepam | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Clotrimazole + Hydrocortisone | Moderate | Antagonism · Metabolism | Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the… | 2 sources — open the full entry |
| Clozapine | Moderate | Synergy | Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking… | 11 sources — open the full entry |
Food & lifestyle
alcohol
ModerateSynergy
Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
What to do: Caution and close monitoring for development of hypotension is advised during coadministration of these agents. Some authorities recommend avoiding alcohol in patients receiving vasodilating antihypertensive drugs. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
8 sources
- Sternbach H "Fluoxetine-associated potentiation of calcium-channel blockers." J Clin Psychopharmacol 11 (1991): 390-1
- Shook TL, Kirshenbaum JM, Hundley RF, Shorey JM, Lamas GA "Ethanol intoxication complicating intravenous nitroglycerin therapy." Ann Intern Med 101 (1984): 498-9
- Feder R "Bradycardia and syncope induced by fluoxetine." J Clin Psychiatry 52 (1991): 139
- Ellison JM, Milofsky JE, Ely E "Fluoxetine-induced bradycardia and syncope in two patients." J Clin Psychiatry 51 (1990): 385-6
- Rodriguez de la Torre B, Dreher J, Malevany I, et al. "Serum levels and cardiovascular effects of tricyclic antidepressants and selective serotonin reuptake inhibitors in depressed patients." Ther Drug Monit 23 (2001): 435-40
- Cerner Multum, Inc. "Australian Product Information." O 0
- Pacher P, Kecskemeti V "Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?" Curr Pharm Des 10 (2004): 2463-75
- Andrews C, Pinner G "Postural hypotension induced by paroxetine." BMJ 316 (1998): 595
Conditions
Conditions in which Diazoxide needs care, as documented in this source.
Arrhythmias, Cardiac
ModerateThe use of diazoxide is associated with compensatory tachycardia. Therapy with diazoxide should be administered cautiously in patients with tachycardia.
1 source
- "Product Information. Hyperstat (diazoxide)." Apothecon Inc (2022):
Gout
ModerateDiazoxide can increase serum uric acid levels due to decreased excretion. This should be kept in mind, particularly in patients with hyperuricemia or a history of gout.
1 source
- "Product Information. Hyperstat (diazoxide)." Apothecon Inc (2022):
Heart Failure
ModerateDiazoxide may lead to significant fluid retention, which may precipitate congestive heart failure in patients with impaired cardiac reserve. The fluid retention will respond to conventional therapy with diuretics. Therapy with diazoxide should be administered cautiously in patients with congestive heart failure.
1 source
- "Product Information. Hyperstat (diazoxide)." Apothecon Inc (2022):
Hypertension, Pulmonary
ModerateThere have been postmarketing reports of pulmonary hypertension in infants and neonates treated with diazoxide. The cases were reversible upon discontinuation of the drug. Patients should be carefully monitored, especially those with risk factors for pulmonary hypertension, or respiratory distress. Diazoxide should be discontinued if pulmonary hypertension is suspected.
1 source
- "Product Information. Hyperstat (diazoxide)." Apothecon Inc (2022):
Kidney Diseases
ModerateThe plasma half-life of diazoxide is prolonged in patients with impaired renal function. A reduced dosage should be considered. Serum electrolyte levels should also be evaluated for such patients. Caution and monitoring is advised.
1 source
- "Product Information. Hyperstat (diazoxide)." Apothecon Inc (2022):