Dutasteride interactions
Full monograph for DutasterideCheck it against another medicine
Medicines
384 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Abametapir | Moderate | Metabolism | Based on in vitro inhibition data, a single topical application of abametapir lotion may increase plasma concentrations of drugs that are substrates of CYP450… | 1 sources — open the full entry |
| Amiodarone Hydrochloride | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Apalutamide | Moderate | Absorption · Metabolism | Coadministration with apalutamide may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 3A4, 2C9, 2C19, breast… | 5 sources — open the full entry |
| Aprepitant | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Asciminib | Moderate | Metabolism | Coadministration with asciminib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is… | 1 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocaine | Moderate | Metabolism · Unknown | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the…3 documented mechanisms | 1 sources — open the full entry |
| Betamethasone + Clotrimazole | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Bicalutamide | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Brigatinib | Moderate | Metabolism | Coadministration with brigatinib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. Brigatinib has been shown in… | 6 sources — open the full entry |
| Ceritinib | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Chloramphenicol (Oral) | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Chloramphenicol + Lidocaine Hydrochloride | Moderate | Metabolism · Unknown | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the…2 documented mechanisms | 1 sources — open the full entry |
| CiprofloxacinbaseOphthalmic | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Ciprofloxacin + Dexamethasone | Moderate | Metabolism · Unknown | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the…2 documented mechanisms | 1 sources — open the full entry |
| Ciprofloxacin + Hydrocortisone Acetate | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Clarithromycin | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| ClotrimazoleEar dropEye ointmentTopicalVaginal tablet | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Clotrimazole + Hydrocortisone | Moderate | Metabolism · Unknown | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the…2 documented mechanisms | 1 sources — open the full entry |
| Crizotinib | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Cyclosporine (Oral) | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Danazol | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Dasatinib | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Deferasirox | Moderate | Metabolism | Coadministration with deferasirox may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism may involve… | 3 sources — open the full entry |
| Dexamethasone + Chloramphenicol | Moderate | Metabolism · Unknown | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the…2 documented mechanisms | 1 sources — open the full entry |
| Diltiazem Hydrochloride | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Efavirenz | Moderate | Metabolism | Coadministration with efavirenz may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is accelerated… | 2 sources — open the full entry |
| Enzalutamide | Moderate | Metabolism | Coadministration with enzalutamide may decrease the plasma concentrations of drugs that are substrates of CYP450 3A4, 2C9, 2C19, and/or P-glycoprotein (P-gp)… | 4 sources — open the full entry |
| ErythromycinLotionOral | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Esomeprazole + Amoxicillin + Clarithromycin | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| FluconazolebaseOphthalmic | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Fluvoxamine Maleate | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Imatinib Mesylate | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Itraconazole | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Ketoconazole | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Ketoconazole + Zinc Pyrithione + Aleovera | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Lamivudine + Zidovudine + Nevirapine | Moderate | Metabolism | Coadministration with nevirapine may decrease the plasma concentrations and therapeutic efficacy of drugs that are substrates of CYP450 3A4. The proposed… | 4 sources — open the full entry |
| Lansoprazole + Amoxicillin + Clarithromycin | Moderate | Metabolism · Unknown | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the…2 documented mechanisms | 1 sources — open the full entry |
| Lapatinib | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Larotrectinib | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Lefamulin Acetate | Moderate | Metabolism | When administered orally, lefamulin may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 3A4. Based on interaction with… | 6 sources — open the full entry |
| Lopinavir + Ritonavir | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Lorlatinib | Moderate | Metabolism | Coadministration with lorlatinib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The proposed mechanism is… | 3 sources — open the full entry |
| Mavacamten | Moderate | Metabolism | Coadministration with mavacamten may decrease the plasma concentrations of drugs that are primarily metabolized by CYP450 3A4, 2C9, and/or 2C19. The proposed… | 1 sources — open the full entry |
| Metronidazole + Miconazole Nitrate | Moderate | Metabolism · Unknown | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the…2 documented mechanisms | 1 sources — open the full entry |
| Miconazole Nitrate | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Miconazole Nitrate + Hydrocortisone | Moderate | Metabolism · Unknown | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the…2 documented mechanisms | 1 sources — open the full entry |
| Miconazole Nitrate + Zinc Oxide + White Soft Paraffin | Moderate | Metabolism | Based on in vitro data, coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dutasteride, which is metabolized by the… | 1 sources — open the full entry |
| Mifepristone | Moderate | Metabolism | Based on in vitro inhibition data, coadministration with mifepristone may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4… | 10 sources — open the full entry |
| Mifepristone + Misoprostol | Moderate | Metabolism | Based on in vitro inhibition data, coadministration with mifepristone may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4… | 10 sources — open the full entry |
Conditions
Conditions in which Dutasteride needs care, as documented in this source.
Liver Diseases
ModerateFinasteride and dutasteride are extensively metabolized by the liver. Therapy with these drugs should be administered cautiously in patients with liver disease as exposure could be higher.
2 sources
- "Product Information. Proscar (finasteride)." Merck & Co., Inc (2002):
- "Product Information. Duagen (dutasteride)." GlaxoSmithKline Healthcare (2002):