Folinic Acid interactions
Checked as Leucovorin in this data source.
Full monograph for Folinic AcidCheck it against another medicine
Medicines
410 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Capecitabine | Major | Synergy | Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU). The exact mechanism of interaction is unknown. Although… | 9 sources — open the full entry |
| Ceftriaxone Sodium | Major | Others | Coadministration of ceftriaxone with calcium-containing solutions, even via different infusion lines, may cause precipitation of ceftriaxone-calcium salt… | 4 sources — open the full entry |
| Fluorouracil | Major | Synergy | Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU). The exact mechanism of interaction is unknown. Although… | 9 sources — open the full entry |
| Sulphamethoxazole + Trimethoprim | Major | Others | Concomitant use of leucovorin with sulfamethoxazole-trimethoprim (SMX-TMP) for the acute treatment of Pneumocystis jiroveci pneumonia (formerly known as… | 5 sources — open the full entry |
| Carbamazepine | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Ethosuximide | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Fosphenytoin Sodium | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Lamotrigine | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Methotrexate | Moderate | Antagonism | Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic… | 4 sources — open the full entry |
| Oxcarbazepine | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Phenobarbital | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Phenytoin Sodium | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Primidone | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Sodium Valproate | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Sulfasalazine | Minor | Absorption · Metabolism | Sulfasalazine may impair the intestinal absorption and/or metabolism of folic acid to its physiologically useful form. Folate deficiency, sometimes manifested… | 15 sources — open the full entry |
Conditions
Conditions in which Folinic Acid needs care, as documented in this source.
Anemia
MajorThe use of leucovorin is inappropriate therapy for patients with undiagnosed anemia. Leucovorin can obscure the diagnosis of pernicious anemia by alleviating the hematologic conditions and allowing progression of neurologic complications.
1 source
- "Product Information. Wellcovorin (leucovorin)." Glaxo Wellcome, Research Triangle Park, NC.
Peptic Ulcer
MajorLeucovorin enhances the toxicity of 5-fluorouracil. When these drugs are administered concurrently in the palliative therapy of advanced colorectal cancer, gastrointestinal toxicities, particularly stomatitis and diarrhea are observed more commonly and may be more severe and of prolonged duration. Therapy with these agents must not be initiated or continued in patients who have symptoms of gastrointestinal toxicity of any severity until those symptoms have completely resolved. Monitor patients experiencing diarrhea and institute appropriate care.
1 source
- "Product Information. Wellcovorin (leucovorin)." Glaxo Wellcome, Research Triangle Park, NC.
Kidney Diseases
ModerateLeucovorin is excreted by the kidney and the risk of toxic reactions to the drug may be greater in patients with impaired renal function. Leucovorin should be used cautiously on these patients, and care should be taken in dose selection. Monitoring of renal function is recommended.
1 source
- "Product Information. Wellcovorin (leucovorin)." Glaxo Wellcome, Research Triangle Park, NC.
Seizures
ModerateSeizures have occurred rarely during administration of leucovorin, primarily in patients receiving high dose leucovorin or leucovorin in combination with 5-fluorouracil, or in patients with a history of seizures or central nervous system abnormalities (unspecified). Folic acid in large amounts may counter the anticonvulsant effects of phenobarbital, phenytoin, and pimozide. Clinical monitoring of seizure activity is recommended and modification of anticonvulsant therapy may be necessary.
1 source
- "Product Information. Wellcovorin (leucovorin)." Glaxo Wellcome, Research Triangle Park, NC.