Insulin Lispro Protamine + Insulin Lispro interactions
Checked as Insulin lispro (protamine) + Insulin lispro in this data source.
Full monograph for Insulin Lispro Protamine + Insulin LisproCheck it against another medicine
Medicines
332 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| CiprofloxacinbaseOphthalmicvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Ciprofloxacin + Dexamethasonevia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…4 documented mechanisms | 145 sources — open the full entry |
| Ciprofloxacin + Hydrocortisone Acetatevia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafinevia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Delafloxacinvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Dexamethasone + Levofloxacinvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…4 documented mechanisms | 145 sources — open the full entry |
| Gatifloxacinvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Gatifloxacin may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of various quinolones has been associated with…2 documented mechanisms | 39 sources — open the full entry |
| Gatifloxacin + Dexamethasonevia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Gatifloxacin may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of various quinolones has been associated with…4 documented mechanisms | 134 sources — open the full entry |
| Gemifloxacinvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Levofloxacin (Eye/Ear)via Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Levofloxacin Hemihydratevia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Lomefloxacinvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism · Others | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 90 sources — open the full entry |
| Loteprednol Etabonate + Gatifloxacinvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Gatifloxacin may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of various quinolones has been associated with…2 documented mechanisms | 39 sources — open the full entry |
| Moxifloxacin HydrochlorideInjectionOphthalmicTabletvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Moxifloxacin Hydrochloride + Dexamethasonevia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…4 documented mechanisms | 145 sources — open the full entry |
| Moxifloxacin Hydrochloride + Xanthan Gumvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Nalidixic Acidvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism · Others | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 90 sources — open the full entry |
| Ofloxacinvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Ofloxacin + Clotrimazole + Beclomethasone + Lidocainevia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 50 sources — open the full entry |
| Sparfloxacinvia Insulin lispro, Insulin lispro (protamine) | Major | Antagonism · Others | Quinolone antibiotics may interfere with the therapeutic effects of insulin and other antidiabetic agents. The use of quinolones has been associated with…2 documented mechanisms | 90 sources — open the full entry |
| Acetazolamidevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Aclidinium Bromide + Formoterol Fumaratevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Acyclovir + Hydrocortisonevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Adenosine + Cytochrome-C + Sodium Succinate + Nicotinamidevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 180 sources — open the full entry |
| Adrenalinevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Alogliptin Benzoatevia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | Coadministration of a dipeptidyl peptidase-4 inhibitor with an insulin secretagogue (e.g., sulfonylurea, meglitinide) or insulin may potentiate the risk of…2 documented mechanisms | 23 sources — open the full entry |
| Alpelisibvia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Amlodipine Besilate + Atenololvia Insulin lispro, Insulin lispro (protamine) | Moderate | Others | Beta-blockers may inhibit some of the normal physiologic response to hypoglycemia. Symptoms of hypoglycemia such as tremor and tachycardia may be absent…2 documented mechanisms | 26 sources — open the full entry |
| Amlodipine Besilate + Benazepril Hydrochloridevia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…2 documented mechanisms | 86 sources — open the full entry |
| Amlodipine Besilate + Olmesartan Medoxomilvia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…2 documented mechanisms | 86 sources — open the full entry |
| Amlodipine Besilate + Telmisartanvia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…2 documented mechanisms | 86 sources — open the full entry |
| Amlodipine Besilate + Valsartanvia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…2 documented mechanisms | 86 sources — open the full entry |
| Aripiprazolevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Articaine Hydrochloride + Epinephrine Bitartratevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Asenapine Maleatevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Aspirinvia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…2 documented mechanisms | 86 sources — open the full entry |
| Aspirin + Dipyridamolevia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…2 documented mechanisms | 86 sources — open the full entry |
| Atenololvia Insulin lispro, Insulin lispro (protamine) | Moderate | Others | Beta-blockers may inhibit some of the normal physiologic response to hypoglycemia. Symptoms of hypoglycemia such as tremor and tachycardia may be absent…2 documented mechanisms | 26 sources — open the full entry |
| Atenolol + Chlorthalidonevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism · Others | Beta-blockers may inhibit some of the normal physiologic response to hypoglycemia. Symptoms of hypoglycemia such as tremor and tachycardia may be absent…4 documented mechanisms | 121 sources — open the full entry |
| Azilsartan Medoxomilvia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…4 documented mechanisms | 162 sources — open the full entry |
| Azilsartan Medoxomil + Chlorthalidonevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism · Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…6 documented mechanisms | 257 sources — open the full entry |
| Beclometasone + Formoterol + Glycopyrroniumvia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Beclomethasone Dipropionate + Formoterol Fumaratevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Benzoic Acid + Salicylic Acidvia Insulin lispro, Insulin lispro (protamine) | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines…2 documented mechanisms | 76 sources — open the full entry |
| Betamethasonevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Betamethasone + Calcipotriolvia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Betamethasone + Clotrimazolevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicinvia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Betamethasone + Neomycin Sulphate (Ophthalmic)via Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Betamethasone + Phenylephrine + Lignocainevia Insulin lispro, Insulin lispro (protamine) | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…4 documented mechanisms | 95 sources — open the full entry |
Food & lifestyle
alcohol
ModerateOthers
Alcohol may cause hypoglycemia or hyperglycemia in patients with diabetes. Hypoglycemia most frequently occurs during acute consumption of alcohol. Even modest amounts can lower blood sugar significantly, especially when the alcohol is ingested on an empty stomach or following exercise. The mechanism involves inhibition of both gluconeogenesis as well as the counter-regulatory response to hypoglycemia.
What to do: Patients with diabetes should avoid consuming alcohol if their blood glucose is not well controlled, or if they have hypertriglyceridemia, neuropathy, or pancreatitis. Patients with well controlled diabetes should limit their alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with their normal meal plan. Alcohol should not be consumed on an empty stomach or following exercise.
10 sources
- Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6
- Jerntorp P, Almer LO, Holin H, et al. "Plasma chlorpropamide: a critical factor in chlorpropamide-alcohol flush." Eur J Clin Pharmacol 24 (1983): 237-42
- Barnett AH, Spiliopoulos AJ, Pyke DA, et al. "Metabolic studies in chlorpropamide-alcohol flush positive and negative type 2 (non-insulin dependent) diabetic patients with and without retinopathy." Diabetologia 24 (1983): 213-5
- Hartling SG, Faber OK, Wegmann ML, Wahlin-Boll E, Melander A "Interaction of ethanol and glipizide in humans." Diabetes Care 10 (1987): 683-6
- "Product Information. Diabinese (chlorpropamide)." Pfizer U.S. Pharmaceuticals (2002):
- "Product Information. Glucotrol (glipizide)." Pfizer U.S. Pharmaceuticals (2002):
- "Product Information. Diabeta (glyburide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
- Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72
Show all 10 sourcesShow fewer sources
- "Position Statement: evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes related complications. American Diabetes Association." Diabetes Care 25(Suppl 1) (2002): S50-S60
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Conditions
Conditions in which Insulin Lispro Protamine + Insulin Lispro needs care, as documented in this source.
Hypoglycemia
ModerateHypoglycemia may commonly occur during treatment with insulin and/or oral hypoglycemic agents. Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during the use of these drugs, including those who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents.
18 sources
- "Product Information. Diabinese (chlorpropamide)." Pfizer U.S. Pharmaceuticals (2002):
- "Product Information. Glucotrol (glipizide)." Pfizer U.S. Pharmaceuticals (2002):
- "Product Information. Diabeta (glyburide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
- "Product Information. Micronase (glyburide)." Pharmacia and Upjohn (2002):
- "Multum Information Services, Inc. Expert Review Panel"
- "Product Information. Humulin BR (insulin)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Glucophage (metformin)." Bristol-Myers Squibb (2001):
- "Product Information. Amaryl (glimepiride)." Hoechst Marion Roussel (2001):
Show all 18 sourcesShow fewer sources
- "Product Information. Prandin (repaglinide)." Novo Nordisk Pharmaceuticals Inc (2001):
- Braunwald E, Hauser SL, Kasper DL, Fauci AS, Isselbacher KJ, Longo DL, Martin JB, eds., Wilson JD "Harrison's Principles of Internal Medicine." New York, NY: McGraw-Hill Health Professionals Division (1998):
- "Product Information. Tolinase (tolazamide)." Pharmacia and Upjohn (2001):
- "Product Information. Dymelor (acetohexamide)." Lilly, Eli and Company (2001):
- "Product Information. Lantus (insulin glargine)." Aventis Pharmaceuticals (2001):
- "Product Information. NovoLOG (insulin aspart)." Novo Nordisk Pharmaceuticals Inc (2022):
- "Product Information. Starlix (nateglinide)." Novartis Pharmaceuticals (2001):
- "Product Information. Apidra (insulin glulisine)." Aventis Pharmaceuticals (2004):
- "Product Information. Levemir (insulin detemir)." Novo Nordisk Pharmaceuticals Inc (2005):
- "Product Information. Tresiba FlexTouch (insulin degludec)." Novo Nordisk Pharmaceuticals Inc (2015):
Hypokalemia
ModerateHypokalemia may commonly occur during treatment with insulin. Use with caution in patients who may be particularly at risk of developing hypokalemia (e.g., patients using potassium-lowering medications, patients taking medications sensitive to serum potassium concentrations).
7 sources
- "Product Information. Humulin BR (insulin)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Lantus (insulin glargine)." Aventis Pharmaceuticals (2001):
- "Product Information. NovoLOG (insulin aspart)." Novo Nordisk Pharmaceuticals Inc (2022):
- "Product Information. Apidra (insulin glulisine)." Aventis Pharmaceuticals (2004):
- "Product Information. Levemir (insulin detemir)." Novo Nordisk Pharmaceuticals Inc (2005):
- "Product Information. Afrezza (insulin inhalation, rapid acting)." MannKind Corporation (2014):
- "Product Information. Tresiba FlexTouch (insulin degludec)." Novo Nordisk Pharmaceuticals Inc (2015):
Liver Diseases
ModerateInsulin requirements may be diminished in patients with renal or hepatic impairment due to reduced insulin metabolism and, in the latter case, also to reduced capacity for gluconeogenesis. Lower initial dosages may be appropriate, with careful monitoring of plasma glucose levels and dosing adjustments.
7 sources
- "Product Information. Humulin BR (insulin)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Lantus (insulin glargine)." Aventis Pharmaceuticals (2001):
- "Product Information. NovoLOG (insulin aspart)." Novo Nordisk Pharmaceuticals Inc (2022):
- "Product Information. Apidra (insulin glulisine)." Aventis Pharmaceuticals (2004):
- "Product Information. Levemir (insulin detemir)." Novo Nordisk Pharmaceuticals Inc (2005):
- "Product Information. Afrezza (insulin inhalation, rapid acting)." MannKind Corporation (2014):
- "Product Information. Tresiba FlexTouch (insulin degludec)." Novo Nordisk Pharmaceuticals Inc (2015):
Therapeutic duplication
Drug classes that overlap with Insulin Lispro Protamine + Insulin Lispro, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
intermediate- and long-acting in
The recommended maximum number of medicines in the 'intermediate- and long-acting insulins' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'intermediate- and long-acting insulins' category.
Example product in the source data (US market): Insulin degludec/liraglutide
intermediate- and long-acting in
The recommended maximum number of medicines in the 'intermediate- and long-acting insulins' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'intermediate- and long-acting insulins' category.
Example product in the source data (US market): Soliqua