Mebendazole interactions
Full monograph for MebendazoleCheck it against another medicine
Medicines
10 documented
Mechanism
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Carbamazepine | Moderate | Metabolism | Coadministration with anticonvulsant drugs such as carbamazepine, phenytoin, phenobarbital, and primidone may decrease mebendazole levels. The mechanism is… | 4 sources — open the full entry |
| Fosphenytoin Sodium | Moderate | Metabolism | Coadministration with anticonvulsant drugs such as carbamazepine, phenytoin, phenobarbital, and primidone may decrease mebendazole levels. The mechanism is… | 4 sources — open the full entry |
| Lopinavir + Ritonavir | Moderate | Metabolism | Coadministration with ritonavir may decrease the plasma concentrations of the benzimidazoles, albendazole and mebendazole, as well as the active metabolite of… | 5 sources — open the full entry |
| Metronidazole | Moderate | Others | Limited clinical data have suggested that coadministration of metronidazole and mebendazole may be associated with Stevens-Johnson syndrome/toxic epidermal… | 18 sources — open the full entry |
| Metronidazole + Miconazole Nitrate | Moderate | Others | Limited clinical data have suggested that coadministration of metronidazole and mebendazole may be associated with Stevens-Johnson syndrome/toxic epidermal… | 18 sources — open the full entry |
| Metronidazole + Neomycin Sulphate + Polymyxin B + Nystatin | Moderate | Others | Limited clinical data have suggested that coadministration of metronidazole and mebendazole may be associated with Stevens-Johnson syndrome/toxic epidermal… | 18 sources — open the full entry |
| Nirmatrelvir + Ritonavir | Moderate | Metabolism | Coadministration with ritonavir may decrease the plasma concentrations of the benzimidazoles, albendazole and mebendazole, as well as the active metabolite of… | 5 sources — open the full entry |
| Phenobarbital | Moderate | Metabolism | Coadministration with anticonvulsant drugs such as carbamazepine, phenytoin, phenobarbital, and primidone may decrease mebendazole levels. The mechanism is… | 4 sources — open the full entry |
| Phenytoin Sodium | Moderate | Metabolism | Coadministration with anticonvulsant drugs such as carbamazepine, phenytoin, phenobarbital, and primidone may decrease mebendazole levels. The mechanism is… | 4 sources — open the full entry |
| Primidone | Moderate | Metabolism | Coadministration with anticonvulsant drugs such as carbamazepine, phenytoin, phenobarbital, and primidone may decrease mebendazole levels. The mechanism is… | 4 sources — open the full entry |
Conditions
Conditions in which Mebendazole needs care, as documented in this source.
Liver Diseases
ModerateAlthough mebendazole is poorly absorbed from the gastrointestinal tract (only 2% to 10% of a dose is absorbed systemically), absorbed drug is primarily metabolized by the liver. Therapy with mebendazole should be administered cautiously in patients with liver disease. Liver function tests should be monitored during extended use or high-dose therapy, since elevation of serum transaminases (AST, ALT) and GGT, as well as rare cases of hepatitis, have been reported during prolonged therapy and at dosages substantially above those normally recommended.
3 sources
- Bekhti A, Pirotte J "Hepatotoxicity of mebendazole: relationship with serum concentrations of the drug." Gastroenterol Clin Biol 11 (1987): 701-3
- Witassek F, Bircher "Chemotherapy of larval echinococcosis with mebendazole: microsomal liver function and cholestasis as determinants of plasma drug level." Eur J Clin Pharmacol 25 (1983): 85-90
- "Product Information. Vermox (mebendazole)." Janssen Pharmaceuticals (2002):