Sevelamer Hydrochloride interactions
Checked as Sevelamer in this data source.
Full monograph for Sevelamer HydrochlorideCheck it against another medicine
Medicines
359 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Erdafitinib | Major | Others | Coadministration with agents that can alter serum phosphate levels may affect the initial dosage determination of erdafitinib. The mechanism appears to be… | 1 sources — open the full entry |
| Alendronic Acid + Vitamin D3 | Moderate | Absorption · Unknown | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical…2 documented mechanisms | 7 sources — open the full entry |
| Algae Calcium + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Beta carotene + Vitamin C + Vitamin E | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Calcitriol | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Calcium + Vitamin D3 + Multimineral | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Calcium Citrate + Calcitriol | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3 + Multiminerals | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Calcium Phosphate [Milk source] + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Cholecalciferol [Vitamin D3] | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| CiprofloxacinbaseOphthalmic | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Ciprofloxacin + Dexamethasone | Moderate | Absorption · Unknown | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially…2 documented mechanisms | 3 sources — open the full entry |
| Ciprofloxacin + Hydrocortisone Acetate | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafine | Moderate | Absorption · Unknown | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially…2 documented mechanisms | 3 sources — open the full entry |
| Conventional Calcium + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Coral Calcium + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Cyclosporine (Oral) | Moderate | Absorption | Coadministration with sevelamer may reduce blood levels of oral cyclosporine, mycophenolate mofetil, and tacrolimus. The mechanism is reduction of absorption… | 8 sources — open the full entry |
| Delafloxacin | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Dexamethasone + Levofloxacin | Moderate | Absorption · Unknown | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially…2 documented mechanisms | 3 sources — open the full entry |
| Doxercalciferol | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Eggshell Calcium + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Eggshell Calcium + Vitamin D3 + 19 Vitamin & Minerals | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Gatifloxacin | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Gatifloxacin + Dexamethasone | Moderate | Absorption · Unknown | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially…2 documented mechanisms | 3 sources — open the full entry |
| Gemifloxacin | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Ibandronic Acid + Algae Calcium + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Ibandronic Acid + Coral Calcium + Vitamin D3 | Moderate | Absorption | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical… | 7 sources — open the full entry |
| Iron + Folic Acid + Vitamin A + Vitamin C + Zinc | Moderate | Absorption · Unknown | INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical…2 documented mechanisms | 7 sources — open the full entry |
| Levofloxacin (Eye/Ear) | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Levofloxacin Hemihydrate | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Levothyroxine Sodium | Moderate | Absorption | INTERVAL: The coadministration of phosphate binders, such as sevelamer and lanthanum, with levothyroxine may increase levels of thyroid stimulating hormone… | 7 sources — open the full entry |
| Lomefloxacin | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Loteprednol Etabonate + Gatifloxacin | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Moxifloxacin HydrochlorideInjectionOphthalmicTablet | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Moxifloxacin Hydrochloride + Dexamethasone | Moderate | Absorption · Unknown | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially…2 documented mechanisms | 3 sources — open the full entry |
| Moxifloxacin Hydrochloride + Xanthan Gum | Moderate | Absorption | INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially… | 3 sources — open the full entry |
| Multivitamin | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin + 5% Amino acid | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin + Cod Liver Oil | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin + L-Lysine | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin [Adult preparation] | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin [Pediatric preparation] | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin [Vitamin B complex + Vitamin C] | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin [water & fat soluble] + 5% Dextrose | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin [water & fat soluble] + Normal Saline | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin [water soluble] + 5% Dextrose | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Multivitamin [water soluble] + Normal Saline | Moderate | Absorption | Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies… | 6 sources — open the full entry |
| Mycophenolate Mofetil | Moderate | Absorption | Coadministration with sevelamer may reduce blood levels of oral cyclosporine, mycophenolate mofetil, and tacrolimus. The mechanism is reduction of absorption… | 8 sources — open the full entry |
Conditions
Conditions in which Sevelamer Hydrochloride needs care, as documented in this source.
Gastrointestinal Diseases
MajorSevelamer is contraindicated in patients with bowel obstruction. Cases of bowel obstruction and perforation have been reported with the use of sevelamer. Care and appropriate measures should be taken if patients develop constipation or worsening of existing constipation while on sevelamer.
2 sources
- "Product Information. Renagel (sevelamer)." Genzyme Corporation (2001):
- "Product Information. Renvela (sevelamer)." Genzyme Corporation (2009):
Deglutition Disorders
ModerateCases of dysphagia and esophageal tablet retention have been reported in association with use of the tablet formulation of sevelamer, some requiring hospitalization and intervention. Consider using sevelamer suspension in patients with a history of swallowing disorders.
2 sources
- "Product Information. Renagel (sevelamer)." Genzyme Corporation (2001):
- "Product Information. Renvela (sevelamer)." Genzyme Corporation (2009):
Kidney Diseases
ModeratePatients on peritoneal dialysis should be closely monitored to ensure the reliable use of appropriate aseptic technique with the prompt recognition and management of any signs and symptoms associated with peritonitis.
2 sources
- "Product Information. Renagel (sevelamer)." Genzyme Corporation (2001):
- "Product Information. Renvela (sevelamer)." Genzyme Corporation (2009):