Sodium Chloride interactions

Medicines

2 documented

Severity

Mechanism

Medicines documented to interact with Sodium Chloride, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Lithium Carbonate	Moderate	Excretion	Large sodium intake may decrease serum lithium levels. Sodium restriction may increase lithium levels. The mechanism is increased renal excretion of lithium in…	6 sources — open the full entry
Tolvaptan	Moderate	Synergy	The use of tolvaptan with other treatments for hyponatremia or medications that increase serum sodium concentration may increase the risk of rapid correction…	4 sources — open the full entry

Conditions in which Sodium Chloride needs care, as documented in this source.

Water-Electrolyte Imbalance
Major
Sodium chloride can induce sodium and water retention and result in hypernatremia, hypokalemia, edema and aggravation of congestive heart failure. Therapy with sodium- containing agents should be administered with extreme caution, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states where there is edema with sodium retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with sodium- containing agents is recommended.
3 sources
1. "Product Information. Megace (megestrol)." Bristol-Myers Squibb (2001):
2. "Product Information. Calcibind (cellulose sodium phosphate)." Mission Pharmacal Company (2001):
3. "Product Information. Sodium Benzoate (sodium benzoate)." Taylor Pharmaceuticals (2001):
Acidosis
Moderate
Administration of excessive amounts of sodium chloride can increase chloride concentrations and cause a loss of bicarbonate that results in metabolic acidosis. Clinical monitoring of acid/base balance and electrolyte concentrations is recommended.
1 source
1. "Product Information. Megace (megestrol)." Bristol-Myers Squibb (2001):