Talazoparib interactions

Conditions

Conditions in which Talazoparib needs care, as documented in this source.

• Bone Marrow Failure Disorders

  Moderate

  Myelosuppression consisting of anemia, leukopenia/neutropenia, and/or thrombocytopenia, have been reported in patients treated with talazoparib. Therapy with talazoparib should not be started in myelosuppressed patients and patients that have not adequately recovered from hematological toxicity caused by previous therapies. If myelosuppression occurs during therapy, dose modifications are recommended. Patients should be closely monitored.

  1 source

  1. "Product Information. Talzenna (talazoparib)." Pfizer U.S. Pharmaceuticals Group (2018):

• Hepatic Insufficiency

  Moderate

  Talazoparib has not been studied in patients with moderate hepatic impairment (total bilirubin >1.5 to 3.0 × upper limit of normal [ULN] and any aspartate aminotransferase [AST]) or severe hepatic impairment (total bilirubin >3.0 × ULN and any AST). No dose adjustment is required for patients with mild hepatic impairment (total bilirubin =1 × ULN and AST > ULN, or total bilirubin >1.0 to 1.5 × ULN and any AST).

  1 source

  1. "Product Information. Talzenna (talazoparib)." Pfizer U.S. Pharmaceuticals Group (2018):

• Kidney Diseases

  Moderate

  Talazoparib has not been studied in patients with severe renal impairment (CrCl < 30 mL/min) or patients requiring hemodialysis. Caution is advised if used in these patients. A dose reduction is recommended in patients with moderate renal impairment (CrCl 30 - 59 mL/min), and no dose adjustment is required for patients with mild renal impairment (CrCl 60 - 89 mL/min).

  1 source

  1. "Product Information. Talzenna (talazoparib)." Pfizer U.S. Pharmaceuticals Group (2018):