Thiopental Sodium interactions
Checked as Thiopental in this data source.
Full monograph for Thiopental SodiumCheck it against another medicine
Medicines
143 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Ethanol + Isopropyl alcohol | Major | Metabolism | Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these… | 5 sources — open the full entry |
| Warfarin Sodium | Major | Metabolism | Barbiturates reduce the effects of oral anticoagulants by inducing their hepatic metabolism. Anticoagulant dosage requirements may be increased by 30% to 60%… | 49 sources — open the full entry |
| Alprazolam | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Aminophylline | Moderate | Metabolism | Barbiturates may decrease serum levels and therapeutic effects of the methylxanthines. The mechanism is barbiturate induction of CYP450 3A4 and 1A2 hepatic… | 4 sources — open the full entry |
| Amiodarone Hydrochloride | Moderate | Others | Amiodarone may increase the effect of general anesthetics due to its adrenergic blocking effects. Data have been conflicting; however, the potential for… | 6 sources — open the full entry |
| Amitriptyline Hydrochloride | Moderate | Antagonism | Tricyclic antidepressants may counteract the anticonvulsive effects of barbiturates by lowering the seizure threshold. Barbiturates may decrease the serum… | 5 sources — open the full entry |
| Amitriptyline Hydrochloride + Chlordiazepoxide | Moderate | Antagonism · Synergy | Tricyclic antidepressants may counteract the anticonvulsive effects of barbiturates by lowering the seizure threshold. Barbiturates may decrease the serum…2 documented mechanisms | 41 sources — open the full entry |
| Amlodipine Besilate | Moderate | Metabolism | Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum… | 22 sources — open the full entry |
| Amlodipine Besilate + Atenolol | Moderate | Metabolism | Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum… | 22 sources — open the full entry |
| Amlodipine Besilate + Atorvastatin | Moderate | Metabolism | Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum… | 22 sources — open the full entry |
| Amlodipine Besilate + Benazepril Hydrochloride | Moderate | Metabolism | Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum… | 22 sources — open the full entry |
| Amlodipine Besilate + Olmesartan Medoxomil | Moderate | Metabolism | Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum… | 22 sources — open the full entry |
| Amlodipine Besilate + Telmisartan | Moderate | Metabolism | Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum… | 22 sources — open the full entry |
| Amlodipine Besilate + Valsartan | Moderate | Metabolism | Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum… | 22 sources — open the full entry |
| Aripiprazole | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Asenapine Maleate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Baclofen | Moderate | Synergy | The concomitant or sequential use of intrathecal baclofen and general anesthetics may increase the risk of seizures and cardiovascular disturbances, and… | 6 sources — open the full entry |
| Bisoprolol Fumarate + Amlodipine Besilate | Moderate | Metabolism | Barbiturates may increase the hepatic metabolism of some dihydropyridine calcium channel blockers by inducing CYP450 3A4 hepatic metabolism. The serum… | 22 sources — open the full entry |
| Brexpiprazole | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Brivaracetam | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Bromocriptine Mesylate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Carbamazepine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Carbidopa + LevodopaExtended releaseProlonged release | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 36 sources — open the full entry |
| Cariprazine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Carisoprodol | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Cenobamate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Cetirizine HydrochloridebaseOphthalmic | Moderate | Synergy | Concurrent use of cetirizine or levocetirizine with alcohol or other agents that exhibit central nervous system (CNS) depressant effects may result in additive… | 10 sources — open the full entry |
| Chloral Hydrate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 36 sources — open the full entry |
| Chlorpheniramine Maleate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 36 sources — open the full entry |
| Cinnarizine + Dimenhydrinate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 36 sources — open the full entry |
| Citalopram Hydrobromide | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Clobazam | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Clomipramine Hydrochloride | Moderate | Antagonism | Tricyclic antidepressants may counteract the anticonvulsive effects of barbiturates by lowering the seizure threshold. Barbiturates may decrease the serum… | 5 sources — open the full entry |
| Clonazepam | Moderate | Metabolism · Synergy | Barbiturates may increase the plasma clearance of clonazepam and thereby reduce its clinical effectiveness. Phenobarbital is the only barbiturate specifically… | 3 sources — open the full entry |
| Clozapine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 36 sources — open the full entry |
| Cyclizine Hydrochloride | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 36 sources — open the full entry |
| Cyclobenzaprine Hydrochloride | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Cyclosporine (Oral) | Moderate | Metabolism | Barbiturates may decrease serum cyclosporine concentrations and efficacy. The mechanism is enhanced hepatic microsomal metabolism of cyclosporine. | 24 sources — open the full entry |
| Dantrolene Sodium | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 36 sources — open the full entry |
| Desvenlafaxine Succinate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Deutetrabenazine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Dexmedetomidine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Dextromethorphan + Bupropion | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Dextromethorphan + Phenylephrine + Triprolidine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Dextromethorphan + Pseudoephedrine + Triprolidine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Dextromethorphan Hydrobromide | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Dextromethorphan Hydrobromide + Guaifenesin | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Dextromethorphan Polistirex | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Difelikefalin Acetate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 36 sources — open the full entry |
| Diphenhydramine + Dextromethorphan + Levomenthol | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…2 documented mechanisms | 44 sources — open the full entry |
Food & lifestyle
alcohol
MajorMetabolism
Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these agents may occur with chronic use. The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.
What to do: The combination of ethanol and barbiturates should be avoided.
5 sources
- Gupta RC, Kofoed J "Toxological statistics for barbiturates, other sedatives, and tranquilizers in Ontario: a 10-year survey." Can Med Assoc J 94 (1966): 863-5
- Misra PS, Lefevre A, Ishii H, Rubin E, Lieber CS "Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats." Am J Med 51 (1971): 346-51
- Saario I, Linnoila M "Effect of subacute treatment with hypnotics, alone or in combination with alcohol, on psychomotor skills related to driving." Acta Pharmacol Toxicol (Copenh) 38 (1976): 382-92
- Stead AH, Moffat AC "Quantification of the interaction between barbiturates and alcohol and interpretation of fatal blood concentrations." Hum Toxicol 2 (1983): 5-14
- Seixas FA "Drug/alcohol interactions: avert potential dangers." Geriatrics 34 (1979): 89-102
Conditions
Conditions in which Thiopental Sodium needs care, as documented in this source.
Addison Disease
MajorThiopental should not be used in patients with Addison disease or any adrenal gland disorder.
No sources recorded
Anemia
MajorThiopental should not be used in patients with severe anemia.
No sources recorded
Asthma
MajorThiopental should not be used in patients with asthma as it can lead to intraoperative bronchospasm which can be catastrophic.
No sources recorded
Kidney Diseases
MajorThiopental should not be used in patients with renal impairment. If so, the dose needs to be considerably reduced.
No sources recorded
Liver Diseases
MajorThiopental should not be used in patients with liver dysfunction. The distribution half-life and the duration of the drug action will be prolonged.
No sources recorded
Myasthenia Gravis
MajorThiopental should not be used in patients with myasthenia gravis as it can prompt myasthenic crises.
No sources recorded
Porphyrias
MajorThe use of thiopental is contraindicated in patients with porphyria.
No sources recorded
Thyroid Diseases
MajorThiopental should not be used in patients with thyroid disorder as it influences thyroid metabolism.
No sources recorded
Therapeutic duplication
Drug classes that overlap with Thiopental Sodium, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
barbiturates
The recommended maximum number of medicines in the 'barbiturates' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'barbiturates' category.
Example product in the source data (US market): Nonbac
barbiturates
The recommended maximum number of medicines in the 'barbiturates' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'barbiturates' category.
Example product in the source data (US market): Laniroif
barbiturates
The recommended maximum number of medicines in the 'barbiturates' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'barbiturates' category.
Example product in the source data (US market): Phenohytro
barbiturates
The recommended maximum number of medicines in the 'barbiturates' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'barbiturates' category.
Example product in the source data (US market): Phrenilin with caffeine and codeine
barbiturates
The recommended maximum number of medicines in the 'barbiturates' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'barbiturates' category.
Example product in the source data (US market): Phrenilin
barbiturates
The recommended maximum number of medicines in the 'barbiturates' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'barbiturates' category.
Example product in the source data (US market): Aspirin/butalbital/caffeine/codeine