Trilaciclib interactions

Conditions

Conditions in which Trilaciclib needs care, as documented in this source.

• Kidney Diseases

  Moderate

  No clinically significant differences in the pharmacokinetics of trilaciclib were observed in patients with mild to moderate renal dysfunction. The effect on the pharmacokinetics in patients with severe renal dysfunction, end-stage renal dysfunction, or dialysis has not been studied. Care should be exercised when using this agent in these patients.

  1 source

  1. "Product Information. Cosela (trilaciclib)." G1 Therapeutics, Inc. (2021):

• Liver Diseases

  Moderate

  The use of trilaciclib is not recommended in patients with moderate or severe liver dysfunction as its pharmacokinetics have not been studied in these patients. No dosage adjustment is recommended for patients with mild liver dysfunction.

  1 source

  1. "Product Information. Cosela (trilaciclib)." G1 Therapeutics, Inc. (2021):

• Respiratory Insufficiency

  Moderate

  The administration of cyclin-dependent kinases 4/6 inhibitors such as trilaciclib can cause severe, life-threatening, or fatal interstitial lung disease (ILD) and/or pneumonitis. It is recommended to exercise caution when using this agent in patients with a history of ILD and/or pneumonitis. Monitor for pulmonary symptoms indicative of ILD/pneumonitis. Interrupt and evaluate patients with new or worsening symptoms suspected to be due to ILD/pneumonitis. Permanently discontinue treatment in patients with recurrent symptomatic or severe/life-threatening ILD/pneumonitis.

  1 source

  1. "Product Information. Cosela (trilaciclib)." G1 Therapeutics, Inc. (2021):