Atropine Sulfate (Ophthalmic) interactions

Checked as Atropine (ophthalmic) in this data source.

Full monograph for Atropine Sulfate (Ophthalmic)Check it against another medicine

Medicines

12 documented

Severity

Mechanism

Medicines documented to interact with Atropine Sulfate (Ophthalmic), worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Betamethasone + Phenylephrine + Lignocaine	Moderate	Synergy	The pressor response to phenylephrine may be potentiated by the vagolytic effect of atropine, which inhibits the reflex bradycardia that would normally…	24 sources — open the full entry
Bethanechol Chloride	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Dextromethorphan + Phenylephrine + Triprolidine	Moderate	Synergy	The pressor response to phenylephrine may be potentiated by the vagolytic effect of atropine, which inhibits the reflex bradycardia that would normally…	24 sources — open the full entry
Donepezil Hydrochloride	Moderate	Antagonism	Acetylcholinesterase inhibitors (e.g., donepezil, galantamine, physostigmine, rivastigmine, tacrine) may antagonize the effects of anticholinergic agents and…	9 sources — open the full entry
Memantine + Donepezil	Moderate	Antagonism	Acetylcholinesterase inhibitors (e.g., donepezil, galantamine, physostigmine, rivastigmine, tacrine) may antagonize the effects of anticholinergic agents and…	9 sources — open the full entry
Phenylephrine + Promethazine	Moderate	Synergy	The pressor response to phenylephrine may be potentiated by the vagolytic effect of atropine, which inhibits the reflex bradycardia that would normally…	24 sources — open the full entry
Phenylephrine Hydrochloride	Moderate	Synergy	The pressor response to phenylephrine may be potentiated by the vagolytic effect of atropine, which inhibits the reflex bradycardia that would normally…	24 sources — open the full entry
Pilocarpine Hydrochloride (Ophthalmic)	Moderate	Antagonism	Theoretically, anticholinergic agents and other agents with significant anticholinergic activity (e.g., antihistamines, antispasmodics, neuroleptics…	2 sources — open the full entry
Pilocarpine Hydrochloride (Oral)	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Rivastigmine Tartrate	Moderate	Antagonism	Acetylcholinesterase inhibitors (e.g., donepezil, galantamine, physostigmine, rivastigmine, tacrine) may antagonize the effects of anticholinergic agents and…	9 sources — open the full entry
Tropicamide + Phenylephrine + Lidocaine	Moderate	Synergy	The pressor response to phenylephrine may be potentiated by the vagolytic effect of atropine, which inhibits the reflex bradycardia that would normally…	24 sources — open the full entry
Tropicamide + Phenylephrine Hydrochloride	Moderate	Synergy	The pressor response to phenylephrine may be potentiated by the vagolytic effect of atropine, which inhibits the reflex bradycardia that would normally…	24 sources — open the full entry

Conditions

Conditions in which Atropine Sulfate (Ophthalmic) needs care, as documented in this source.

Glaucoma
Major
Anticholinergic agents are contraindicated in patients with primary glaucoma, a tendency toward glaucoma (narrow anterior chamber angle), or adhesions (synechiae) between the iris and lens, as well as for the elderly and others in whom undiagnosed glaucoma or excessive pressure in the eye may be present. Because anticholinergics cause mydriasis, they may exacerbate these conditions.
23 sources
1. Schuller DE, Turkewitz D "Adverse effects of antihistamines." Postgrad Med 79 (1986): 75-86
2. "Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories (2002):
3. "Product Information. Chlor-Trimeton (chlorpheniramine)." Schering-Plough
4. "Product Information. Thorazine (chlorpromazine)." SmithKline Beecham (2002):
5. "Product Information. Periactin (cyproheptadine)." Merck & Co., Inc (2002):
6. "Product Information. Benadryl (diphenhydramine)." Parke-Davis (2002):
7. "Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories (2001):
8. "Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation (2001):
Show all 23 sourcesShow fewer sources
1. "Product Information. Optimine (azatadine)." Schering Corporation (2001):
2. O'Connor PS, Mumma JV "Atropine toxicity." Am J Ophthalmol 99 (1985): 613-4
3. Clearkin LG "Angle closure glaucoma precipitated by atropine." Arch Intern Med 152 (1992): 880
4. Berdy GJ, Berdy SS, Odin LS, Hirst LW "Angle closure glaucoma precipitated by aerosolized atropine." Arch Intern Med 151 (1991): 1658-60
5. Pecora JL "Malignant glaucoma worsened by miotics in a postoperative angle- closure glaucoma patient." Ann Ophthalmol 11 (1979): 1412-4
6. Holland MG "Autonomic drugs in ophthalmology: some problems and promises. Section II: Anticholinergic drugs." Ann Ophthalmol 6 (1974): 661-4
7. Kanto J "New aspects in the use of atropine." Int J Clin Pharmacol Ther Toxicol 21 (1983): 92-4
8. "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics (2022):
9. "Product Information. Compazine (prochlorperazine)." SmithKline Beecham (2001):
10. Goldstein JH "Effects of drugs on cornea, conjunctiva, and lids." Int Ophthalmol Clin 11 (1971): 13-34
11. "Product Information. Cogentin (benztropine)." Merck & Co., Inc (2001):
12. "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories (2001):
13. "Product Information. Moban (molindone)." Gate Pharmaceuticals (2001):
14. "Product Information. Orap (pimozide)." Gate Pharmaceuticals
15. "Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmacal Company (2001):
Hypertension
Minor
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
7 sources
1. "Product Information. Benadryl (diphenhydramine)." Parke-Davis (2002):
2. "Product Information. Antivert (meclizine)." Roerig Division (2001):
3. "Product Information. Marezine (cyclizine)." Glaxo Wellcome (2001):
4. Valentin N, Staffeldt H, Kyst A "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand 28 (1984): 621-4
5. "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics (2022):
6. "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories (2001):
7. "Product Information. Atropisol (atropine ophthalmic)." Ciba Vision Ophthalmics (2002):

Medicines

Conditions

Glaucoma

Hypertension