Pilocarpine Hydrochloride (Oral) interactions

Checked as Pilocarpine in this data source.

Full monograph for Pilocarpine Hydrochloride (Oral)Check it against another medicine

Medicines

332 documented

Severity

Mechanism

Medicines documented to interact with Pilocarpine Hydrochloride (Oral), worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Aclidinium Bromide + Formoterol Fumarate	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Alectinib	Moderate	Synergy	Coadministration of alectinib with other agents that can slow the heart rate may increase the risk of bradycardia.	4 sources — open the full entry
Amlodipine Besilate + Atenolol	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Atenolol	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Atenolol + Chlorthalidone	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Atropine Sulfate (Injection)	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Atropine Sulfate (Ophthalmic)	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Beclometasone + Formoterol + Glycopyrronium	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Betaxolol Hydrochloride	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Bimatoprost + Timolol	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Bisoprolol Fumarate	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Bisoprolol Fumarate + Amlodipine Besilate	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Bisoprolol Fumarate + Hydrochlorothiazide	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Brigatinib	Moderate	Synergy	Coadministration of brigatinib with other agents that can also slow the heart rate may potentiate the risk of severe bradycardia.	2 sources — open the full entry
Brimonidine Tartrate + Timolol Maleate	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Brinzolamide + Timolol	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Budesonide + Glycopyrronium Bromide + Formoterol Fumarate	Moderate	Antagonism · Unknown	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…2 documented mechanisms	2 sources — open the full entry
Carvedilol	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Cinnarizine + Dimenhydrinate	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Clozapine	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Crizotinib	Moderate	Synergy	Crizotinib can cause bradycardia and may have additive effects with other drugs that also slow the heart rate.	4 sources — open the full entry
Cyclizine Hydrochloride	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Cyclopentolate Hydrochloride	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Darifenacin	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Dicycloverine Hydrochloride	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Dorzolamide + Timolol	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Esmolol Hydrochloride	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Flavoxate Hydrochloride	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Formoterol Fumarate + Glycopyrrolate + Budesonide	Moderate	Antagonism · Unknown	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…2 documented mechanisms	2 sources — open the full entry
Glycopyrronium BromideInhalation capsule Injection Oral solution Respirator Solution	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Glycopyrronium Bromide + Formoterol Fumarate	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Homatropine Hydrobromide	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Hyoscine Butylbromide	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Hyoscine Hydrobromide	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Indacaterol + Glycopyrronium	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Indacaterol + Glycopyrronium + Mometasone Furoate	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Ipratropium Bromide	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Ivabradine	Moderate	Synergy	Coadministration of ivabradine with other drugs that can slow the heart rate such as beta-blockers, calcium channel blockers, and digitalis may increase the…	4 sources — open the full entry
Labetalol Hydrochloride	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Lasmiditan Hemisuccinate	Moderate	Synergy	Coadministration of lasmiditan and agents that lower heart rate may increase the risk of bradycardia.	1 sources — open the full entry
Latanoprost + Timolol	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Meclizine + Pyridoxine	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Meclizine Hydrochloride	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Metoprolol Tartrate	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Nebivolol + Hydrochlorothiazide	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Nebivolol + Valsartan	Moderate	Others · Unknown	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.2 documented mechanisms	1 sources — open the full entry
Nebivolol Hydrochloride	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry
Procyclidine Hydrochloride	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Propantheline Bromide	Moderate	Antagonism	Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may…	2 sources — open the full entry
Propranolol Hydrochloride	Moderate	Others	The concomitant use of oral pilocarpine and beta blockers may lead to cardiac conduction disturbances. The mechanism is unknown.	1 sources — open the full entry

Conditions

Conditions in which Pilocarpine Hydrochloride (Oral) needs care, as documented in this source.

Bronchial Spasm
Major
The use of cholinergic agonists is contraindicated in patients with uncontrolled reactive airway disease. Cholinergic agonists inhibits the hydrolysis of acetylcholine. The enhanced effect of acetylcholine produces constriction of the bronchi, increased bronchial secretions, and bronchospasm.
2 sources
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim
2. "Product Information. Urecholine (bethanechol)." Merck & Co., Inc (2001):
Epilepsy
Major
The use of cholinergic agonists may be contraindicated in patients with seizure disorders. Cholinomimetics have been associated with convulsions.
2 sources
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim
2. "Product Information. Urecholine (bethanechol)." Merck & Co., Inc (2001):
Glaucoma
Major
The use of pilocarpine is contraindicated in conditions where miosis is undesirable, such as acute iritis and in narrow-angle (angle closure) glaucoma.
1 source
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim
Heart Failure
Major
The use of cholinergic agonists, such as bethanechol and pilocarpine, is contraindicated in patients with pronounced bradycardia, hypotension/hypertension, coronary artery disease or conduction disorders.
2 sources
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim
2. "Product Information. Urecholine (bethanechol)." Merck & Co., Inc (2001):
Hyperthyroidism
Major
The use of cholinergic agents may be contraindicated in patients with hyperthyroidism. Atrial fibrillation has occurred in hyperthyroid patients administered a cholinergic agonist.
2 sources
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim
2. "Product Information. Urecholine (bethanechol)." Merck & Co., Inc (2001):
Parkinsonian Disorders
Major
The use of cholinergic agonists may be contraindicated in patients with parkinsonism. Cholinergic agonists directly stimulates the parasympathetic nervous system inducing acetylcholinergic effects. Symptoms of Parkinson's disease may be exacerbated.
2 sources
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim
2. "Product Information. Urecholine (bethanechol)." Merck & Co., Inc (2001):
Urinary Bladder Neck Obstruction
Major
The use of cholinergic agonists is contraindicated in patients with peptic ulcers, mechanical GI obstruction, acute GI inflammatory conditions, or urinary obstruction. Cholinergic activity may result in an increase in gastric acid secretion, GI motility, and gastric contractions. In patients with urinary retention, urinary reflux may occur if the sphincter fails to relax when the bladder is contracted by cholinergic stimulation. The reflux of urine from the bladder can cause infection in the kidneys and upper urinary tract if bacteriuria is present.
2 sources
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim
2. "Product Information. Urecholine (bethanechol)." Merck & Co., Inc (2001):
Cholelithiasis
Moderate
Pilocarpine should be administered with caution to patients with known or suspected cholelithiasis or biliary tract disease. Contractions of the gallbladder or biliary smooth muscle could precipitate complications including cholecystitis, cholangitis, and biliary obstruction.
1 source
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim
Nephrolithiasis
Moderate
Pilocarpine may increase ureteral smooth muscle tone and could theoretically precipitate renal colic (or ureteral reflux), particularly in patients with nephrolithiasis. Caution is advised when used on these patients.
1 source
1. "Product Information. Salagen (pilocarpine)." Boehringer-Ingelheim

Therapeutic duplication

Drug classes that overlap with Pilocarpine Hydrochloride (Oral), so taking both doubles up the same effect. This source publishes no per-row citations for duplication.

cholinergics
The recommended maximum number of medicines in the 'cholinergics' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'cholinergics' category.
Example product in the source data (US market): Glycopyrrolate/neostigmine

Medicines

Conditions

Bronchial Spasm

Epilepsy

Glaucoma

Heart Failure

Hyperthyroidism

Parkinsonian Disorders

Urinary Bladder Neck Obstruction

Cholelithiasis

Nephrolithiasis

Therapeutic duplication

cholinergics