Baclofen interactions

Food & lifestyle

• alcohol

  Moderate

  Synergy

  Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

  What to do: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

  4 sources

  1. Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
  2. Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
  3. "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
  4. "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):

Conditions

Conditions in which Baclofen needs care, as documented in this source.

• Kidney Diseases

  Major

  Baclofen is primarily eliminated by the kidney. Patients with impaired renal function may be at greater risk for adverse effects from baclofen due to decreased drug clearance. Therapy with baclofen should be administered cautiously in such patients. Dosage adjustments may be necessary.

  3 sources

  1. Himmelsbach FA, Kohler E, Zanker B "Toxic effect of baclofen in chronic haemodialysis and renal transplantation." Dtsch Med Wochenschr 117 (1992): 733-7
  2. Krahn A, Penner SB "Use of baclofen for intractable hiccups in uremia." Am J Med 96 (1994): 391
  3. "Product Information. Lioresal (baclofen)." Medtronic Neurological (2001):

• Autonomic Dysreflexia

  Moderate

  Therapy with intrathecal baclofen should be administered cautiously in patients with a history of autonomic dysreflexia, since the presence of nociceptive stimuli or abrupt withdrawal of the medication may trigger an episode of dysreflexia.

  1 source

  1. "Product Information. Lioresal Intrathecal (baclofen)." Medtronic Neurological (2001):

• Epilepsy

  Moderate

  Deterioration in seizure control and electroencephalographic (EEG) changes have been reported occasionally in epileptic patients treated with baclofen. Therapy with baclofen should be administered cautiously in patients with a history of seizures. Clinical status and EEG should be monitored at regular intervals during treatment. Except in cases of overdose or severe adverse reactions, cessation of baclofen therapy, whenever necessary, should occur gradually with incrementally reduced dosages. Abrupt withdrawal has been associated with central nervous system effects including seizures, hallucinations, and psychosis.

  15 sources

  1. Kirubakaran V, Mayfield D, Rengachary S "Dyskinesia and psychosis in a patient following baclofen withdrawal." Am J Psychiatry 141 (1984): 692-3
  2. Arnold ES, Rudd SM, Kirshner H "Manic psychosis following rapid withdrawal from baclofen." Am J Psychiatry 137 (1980): 1466-7
  3. Siegfried RN, Jacobson L, Chabal C "Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity." Anesthesiology 77 (1992): 1048-50
  4. Abarbanel J, Herishanu Y, Frisher S "Encephalopathy associated with baclofen." Ann Neurol 17 (1985): 617-8
  5. Terrence CF, Fromm GH "Complications of baclofen withdrawal." Arch Neurol 38 (1981): 588-9
  6. Hormes JT, Benarroch EE, Rodriguez M, Klass DW "Periodic sharp waves in baclofen-induced encephalopathy." Arch Neurol 45 (1988): 814-5
  7. Penn RD "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg 77 (1992): 236-40
  8. Rush JM, Gibberd FB "Baclofen-induced epilepsy." J R Soc Med 83 (1990): 115-6

  Show all 15 sourcesShow fewer sources

  9. Rivas DA, Chancellor MB, Hill K, Freedman MK "Neurological manifestations of baclofen withdrawal." J Urol 150 (1993): 1903-5
  10. Barker I, Grant IS "Convulsions after abrupt withdrawal of baclofen." Lancet 2 (1982): 556-7
  11. Lees AJ, Clarke CR, Harrison MJ "Hallucinations after sudden withdrawal of baclofen." Lancet 2 (1977): 44-5
  12. Kofler M, Arturo Leis A "Prolonged seizure activity after baclofen withdrawal." Neurology 42 (1992): 697-8
  13. Garabedian-Ruffalo SM, Ruffalo RL "Adverse effects secondary to baclofen withdrawal." Drug Intell Clin Pharm 19 (1985): 304-6
  14. "Product Information. Lioresal (baclofen)." Medtronic Neurological (2001):
  15. Zak R, Solomon G, Petito F, Labar D "Baclofen-induced generalized nonconvulsive status epilepticus." Ann Neurol 36 (1994): 113-4

• Psychotic Disorders

  Moderate

  Baclofen may precipitate or exacerbate psychotic symptoms, both during therapy and following abrupt withdrawal of the drug. Therapy with baclofen should be administered cautiously in patients with a history of psychiatric disorders.

  15 sources

  1. Kirubakaran V, Mayfield D, Rengachary S "Dyskinesia and psychosis in a patient following baclofen withdrawal." Am J Psychiatry 141 (1984): 692-3
  2. Arnold ES, Rudd SM, Kirshner H "Manic psychosis following rapid withdrawal from baclofen." Am J Psychiatry 137 (1980): 1466-7
  3. Siegfried RN, Jacobson L, Chabal C "Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity." Anesthesiology 77 (1992): 1048-50
  4. Terrence CF, Fromm GH "Complications of baclofen withdrawal." Arch Neurol 38 (1981): 588-9
  5. Sommer BR, Petrides G "A case of baclofen-induced psychotic depression." J Clin Psychiatry 53 (1992): 211-2
  6. Yassa RY, Iskandar HL "Baclofen-induced psychosis: two cases and a review." J Clin Psychiatry 49 (1988): 318-20
  7. Penn RD "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg 77 (1992): 236-40
  8. Rivas DA, Chancellor MB, Hill K, Freedman MK "Neurological manifestations of baclofen withdrawal." J Urol 150 (1993): 1903-5

  Show all 15 sourcesShow fewer sources

  9. Lees AJ, Clarke CR, Harrison MJ "Hallucinations after sudden withdrawal of baclofen." Lancet 2 (1977): 44-5
  10. Wolf ME, Almy G, Toll M, Mosnaim AD "Mania associated with the use of baclofen." Biol Psychiatry 17 (1982): 757-9
  11. Sandyk R, Gillman MA "Baclofen-induced memory impairment." Clin Neuropharmacol 8 (1985): 294-5
  12. Garabedian-Ruffalo SM, Ruffalo RL "Adverse effects secondary to baclofen withdrawal." Drug Intell Clin Pharm 19 (1985): 304-6
  13. Stewart JT "A case of mania associated with high-dose baclofen therapy." J Clin Psychopharmacol 12 (1992): 215-7
  14. Jamous A, Kennedy P, Psychol C, Grey N "Psychological and emotional effects of the use of oral baclofen - a preliminary study." Paraplegia 32 (1994): 349-53
  15. "Product Information. Lioresal (baclofen)." Medtronic Neurological (2001):

Therapeutic duplication

Drug classes that overlap with Baclofen, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.

• muscle relaxants

  The recommended maximum number of medicines in the 'muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'muscle relaxants' category.

  Example product in the source data (US market): Orphengesic forte

• muscle relaxants

  The recommended maximum number of medicines in the 'muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'muscle relaxants' category.

  Example product in the source data (US market): Soma compound with codeine

• muscle relaxants

  The recommended maximum number of medicines in the 'muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'muscle relaxants' category.

  Example product in the source data (US market): Aspirin/methocarbamol

• muscle relaxants

  The recommended maximum number of medicines in the 'muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'muscle relaxants' category.

  Example product in the source data (US market): Aspirin/carisoprodol

• muscle relaxants

  The recommended maximum number of medicines in the 'muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'muscle relaxants' category.

  Example product in the source data (US market): Nodolor