Ceftazidime + Avibactam interactions

Conditions

Conditions in which Ceftazidime + Avibactam needs care, as documented in this source.

• Colitis

  Major

  Clostridioides difficile-associated diarrhea (CDAD), formerly pseudomembranous colitis, has been reported with almost all antibacterial drugs and may range from mild diarrhea to fatal colitis. The most common culprits include clindamycin and lincomycin. Antibacterial therapy alters the normal flora of the colon, leading to overgrowth of C difficile, whose toxins A and B contribute to CDAD development. Morbidity and mortality are increased with hypertoxin-producing strains of C difficile; these infections can be resistant to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea after antibacterial use. Since CDAD has been reported to occur more than 2 months after antibacterial use, careful medical history is necessary. Therapy with broad-spectrum antibacterials and other agents with significant antibacterial activity should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis; pseudomembranous colitis (generally characterized by severe, persistent diarrhea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus), if it occurs, may be more severe in these patients and may be associated with flares in underlying disease activity. Antibacterial drugs not directed against C difficile may need to be stopped if CDAD is suspected or confirmed. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation should be started as clinically indicated.

  31 sources

  1. "Product Information. Omnipen (ampicillin)." Wyeth-Ayerst Laboratories (2002):
  2. "Product Information. Ceftin (cefuroxime)." Glaxo Wellcome (2002):
  3. "Product Information. Zinacef (cefuroxime)." Glaxo Wellcome (2002):
  4. "Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn (2002):
  5. "Product Information. Macrobid (nitrofurantoin)." Procter and Gamble Pharmaceuticals (2002):
  6. "Product Information. Macrodantin (nitrofurantoin)." Procter and Gamble Pharmaceuticals (2002):
  7. "Product Information. Amoxil (amoxicillin)." SmithKline Beecham (2001):
  8. "Product Information. Merrem (meropenem)." Astra-Zeneca Pharmaceuticals (2001):

  Show all 31 sourcesShow fewer sources

  9. "Product Information. Coly-Mycin M Parenteral (colistimethate)." Parke-Davis (2001):
  10. "Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn (2001):
  11. "Product Information. Cubicin (daptomycin)." Cubist Pharmaceuticals Inc (2003):
  12. "Product Information. Xifaxan (rifaximin)." Salix Pharmaceuticals (2004):
  13. "Product Information. Doribax (doripenem)." Ortho McNeil Pharmaceutical (2007):
  14. "Product Information. Penicillin G Procaine (procaine penicillin)." Monarch Pharmaceuticals Inc (2009):
  15. "Product Information. Vibativ (telavancin)." Theravance Inc (2009):
  16. "Product Information. Teflaro (ceftaroline)." Forest Pharmaceuticals (2010):
  17. "Product Information. Penicillin G Sodium (penicillin G sodium)." Sandoz Inc (2022):
  18. "Product Information. Dalvance (dalbavancin)." Durata Therapeutics, Inc. (2014):
  19. "Product Information. Orbactiv (oritavancin)." The Medicines Company (2014):
  20. "Product Information. Bicillin C-R (benzathine penicillin-procaine penicillin)." A-S Medication Solutions (2017):
  21. "Product Information. Baxdela (delafloxacin)." Melinta Therapeutics, Inc. (2017):
  22. "Product Information. Polymyxin B Sulfate (polymyxin B sulfate)." AuroMedics Pharma LLC (2022):
  23. "Product Information. Zemdri (plazomicin)." Achaogen (2018):
  24. "Product Information. Seysara (sarecycline)." Allergan Inc (2018):
  25. "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc. (2018):
  26. "Product Information. Aemcolo (rifamycin)." Aries Pharmaceuticals, Inc. (2018):
  27. "Product Information. Fetroja (cefiderocol)." Shionogi USA Inc (2019):
  28. "Product Information. Biaxin (clarithromycin)." AbbVie US LLC (2019):
  29. "Product Information. Zithromax (azithromycin)." Pfizer U.S. Pharmaceuticals Group (2021):
  30. "Product Information. E.E.S.-400 Filmtab (erythromycin)." Arbor Pharmaceuticals (2018):
  31. "Product Information. Priftin (rifapentine)." sanofi-aventis (2020):

• Diseases requiring dialysis

  Moderate

  Most cephalosporin antibiotics are removed by hemodialysis. Doses should either be scheduled for administration after dialysis or supplemental doses be given after dialysis. Cefonicid, cefixime, and ceftriaxone are not significantly removed by hemodialysis.

  24 sources

  1. "Product Information. Ceclor (cefaclor)." Lilly, Eli and Company (2002):
  2. "Product Information. Duricef (cefadroxil)." Bristol-Myers Squibb (2002):
  3. "Product Information. Ancef (cefazolin)." SmithKline Beecham (2002):
  4. "Product Information. Suprax (cefixime)." Lupin Pharmaceuticals Inc (2002):
  5. "Product Information. Monocid (cefonicid)." SmithKline Beecham (2002):
  6. "Product Information. Cefobid (cefoperazone)." Roerig Division (2002):
  7. "Product Information. Claforan (cefotaxime)." Hoechst Marion Roussel (2002):
  8. "Product Information. Cefotan (cefotetan)." Stuart Pharmaceuticals (2002):

  Show all 24 sourcesShow fewer sources

  9. "Product Information. Mefoxin (cefoxitin)." Merck & Co., Inc (2002):
  10. "Product Information. Vantin (cefpodoxime)." Pharmacia and Upjohn (2002):
  11. "Product Information. Cefzil (cefprozil)." Bristol-Myers Squibb (2002):
  12. "Product Information. Tazicef (ceftazidime)." SmithKline Beecham (2002):
  13. "Product Information. Cefizox (ceftizoxime)." Fujisawa (2002):
  14. "Product Information. Rocephin (ceftriaxone)." Roche Laboratories (2002):
  15. "Product Information. Keflex (cephalexin)." Dista Products Company (2002):
  16. "Product Information. Velosef (cephradine)." Apothecon Inc (2002):
  17. "Product Information. Keflin (cephalothin)." Lilly, Eli and Company (2002):
  18. "Product Information. Cefadyl (cephapirin)." Apothecon Inc (2002):
  19. "Product Information. Lorabid (loracarbef)." Lilly, Eli and Company (2002):
  20. "Product Information. Mandol (cefamandole)." Lilly, Eli and Company (2001):
  21. "Product Information. Cedax (ceftibuten)." Schering-Plough (2001):
  22. "Product Information. Maxipime (cefepime)." Bristol-Myers Squibb (2001):
  23. "Product Information. Omnicef (cefdinir)." Parke-Davis (2001):
  24. "Product Information. Spectracef (cefditoren)." TAP Pharmaceuticals Inc (2001):

• Epilepsy

  Moderate

  Cephalosporins have been implicated in triggering seizures. Nonconvulsive status epilepticus (NCSE), encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia have been reported with cephalosporins particularly in patients with a history of epilepsy and/or when recommended dosages of cephalosporins were exceeded due to renal impairment. Adjust dosing based on creatinine clearance. Anticonvulsant therapy should be continued in patients with known seizure disorders. If CNS adverse reactions including seizures occur, patients should undergo a neurological evaluation to determine whether treatment should be discontinued.

  19 sources

  1. "Product Information. Vantin (cefpodoxime)." Pharmacia and Upjohn
  2. "Product Information. Ceclor (cefaclor)." Lilly, Eli and Company (2002):
  3. "Product Information. Duricef (cefadroxil)." Bristol-Myers Squibb (2002):
  4. "Product Information. Ancef (cefazolin)." SmithKline Beecham (2002):
  5. "Product Information. Kefzol (cefazolin)." Lilly, Eli and Company (2002):
  6. "Product Information. Suprax (cefixime)." Lupin Pharmaceuticals Inc (2002):
  7. "Product Information. Claforan (cefotaxime)." Hoechst Marion Roussel (2002):
  8. "Product Information. Cefotan (cefotetan)." Stuart Pharmaceuticals (2002):

  Show all 19 sourcesShow fewer sources

  9. "Product Information. Mefoxin (cefoxitin)." Merck & Co., Inc (2002):
  10. "Product Information. Cefzil (cefprozil)." Bristol-Myers Squibb (2002):
  11. "Product Information. Fortaz (ceftazidime)." Glaxo Wellcome (2002):
  12. "Product Information. Cefizox (ceftizoxime)." Fujisawa (2002):
  13. "Product Information. Keflex (cephalexin)." Dista Products Company (2002):
  14. "Product Information. Cedax (ceftibuten)." Schering-Plough (2001):
  15. "Product Information. Maxipime (cefepime)." Bristol-Myers Squibb (2001):
  16. "Product Information. Omnicef (cefdinir)." Parke-Davis (2001):
  17. "Product Information. Ceclor CD (cefaclor)." Dura Pharmaceuticals (2001):
  18. "Product Information. Spectracef (cefditoren)." TAP Pharmaceuticals Inc (2001):
  19. "Product Information. Fetroja (cefiderocol)." Shionogi USA Inc (2019):

• Heart Failure

  Moderate

  Fortaz, Tazicef, and Tazidime (brands of parenteral ceftazidime pentahydrate) are formulated with sodium carbonate and contain approximately 53 mg (2.3 mEq) of sodium per each gram of ceftazidime activity. The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention. Ceptaz, another brand of ceftazidime, is formulated with l-arginine and contains no sodium.

  4 sources

  1. "Product Information. Fortaz (ceftazidime)." Glaxo Wellcome (2002):
  2. "Product Information. Tazicef (ceftazidime)." SmithKline Beecham (2002):
  3. "Product Information. Ceptaz (ceftazidime)." Glaxo Wellcome (2001):
  4. "Product Information. Tazidime (ceftazidime)." Lilly, Eli and Company (2001):

• Kidney Diseases

  Moderate

  Most beta-lactam antibiotics are eliminated by the kidney as unchanged drug and, in some cases, also as metabolites. The serum concentrations of beta-lactam antibiotics and their metabolites may be increased, and the half-lives prolonged, in patients with impaired renal function. Neurotoxic reactions (e.g., encephalopathy, asterixis, myoclonus, seizures, coma) have been reported in such patients treated parenterally with these agents. Dosage adjustments may be necessary, and modifications should be based on the degree of renal impairment as well as severity of infection in accordance with the individual product package labeling. Renal function tests should be performed periodically during prolonged and/or high-dose therapy since nephrotoxicity and alterations in renal function have occasionally been associated with the use of these drugs.

  21 sources

  1. "Product Information. Omnipen (ampicillin)." Wyeth-Ayerst Laboratories (2002):
  2. "Product Information. Ancef (cefazolin)." SmithKline Beecham (2002):
  3. "Product Information. Zefazone (cefmetazole)." Pharmacia and Upjohn (2002):
  4. "Product Information. Monocid (cefonicid)." SmithKline Beecham (2002):
  5. "Product Information. Claforan (cefotaxime)." Hoechst Marion Roussel (2002):
  6. "Product Information. Cefotan (cefotetan)." Stuart Pharmaceuticals (2002):
  7. "Product Information. Mefoxin (cefoxitin)." Merck & Co., Inc (2002):
  8. "Product Information. Fortaz (ceftazidime)." Glaxo Wellcome (2002):

  Show all 21 sourcesShow fewer sources

  9. "Product Information. Tazicef (ceftazidime)." SmithKline Beecham (2002):
  10. "Product Information. Cefizox (ceftizoxime)." Fujisawa (2002):
  11. "Product Information. Ceftin (cefuroxime)." Glaxo Wellcome (2002):
  12. "Product Information. Zinacef (cefuroxime)." Glaxo Wellcome (2002):
  13. "Product Information. Keflin (cephalothin)." Lilly, Eli and Company (2002):
  14. "Product Information. Cefadyl (cephapirin)." Apothecon Inc (2002):
  15. "Product Information. Staphcillin (methicillin)." Apothecon Inc (2002):
  16. "Product Information. Pfizerpen (penicillin)." Roerig Division (2001):
  17. "Product Information. Pipracil (piperacillin)." Lederle Laboratories (2001):
  18. "Product Information. Ticar (ticarcillin)." SmithKline Beecham (2001):
  19. "Product Information. Mandol (cefamandole)." Lilly, Eli and Company (2001):
  20. "Product Information. Maxipime (cefepime)." Bristol-Myers Squibb (2001):
  21. "Product Information. Fetroja (cefiderocol)." Shionogi USA Inc (2019):

• Kidney Diseases

  Moderate

  Decreased clinical response has been observed in adult patients treated with the combination product, ceftazidime and avibactam for complicated intra-abdominal infections (cIAI) with baseline creatinine clearance (CrCl) of 30 to less than or equal to 50 mL/min. The decreased clinical response is not observed for patients with moderate renal impairment at baseline (CrCl of 30 to less than or equal to 50 mL/min). It is recommended to monitor CrCl at least daily in adult and pediatric patients with changing renal function and adjust the dosage of treatment according to manufacturer recommendations.

  1 source

  1. "Product Information. Avycaz (avibactam-ceftazidime)." Forest Pharmaceuticals (2015):

• Liver Diseases

  Moderate

  Cases of hepatitis have been reported with the use of certain cephalosporins. Transient rise in AST, ALT, and alkaline phosphatase levels have also been observed. Caution and monitoring is recommended when these agents are prescribed to patients with hepatic disorders.

  20 sources

  1. "Product Information. Vantin (cefpodoxime)." Pharmacia and Upjohn
  2. "Product Information. Ceclor (cefaclor)." Lilly, Eli and Company (2002):
  3. "Product Information. Duricef (cefadroxil)." Bristol-Myers Squibb (2002):
  4. "Product Information. Ancef (cefazolin)." SmithKline Beecham (2002):
  5. "Product Information. Kefzol (cefazolin)." Lilly, Eli and Company (2002):
  6. "Product Information. Suprax (cefixime)." Lupin Pharmaceuticals Inc (2002):
  7. "Product Information. Claforan (cefotaxime)." Hoechst Marion Roussel (2002):
  8. "Product Information. Cefotan (cefotetan)." Stuart Pharmaceuticals (2002):

  Show all 20 sourcesShow fewer sources

  9. "Product Information. Mefoxin (cefoxitin)." Merck & Co., Inc (2002):
  10. "Product Information. Cefzil (cefprozil)." Bristol-Myers Squibb (2002):
  11. "Product Information. Fortaz (ceftazidime)." Glaxo Wellcome (2002):
  12. "Product Information. Cefizox (ceftizoxime)." Fujisawa (2002):
  13. "Product Information. Ceftin (cefuroxime)." Glaxo Wellcome (2002):
  14. "Product Information. Zinacef (cefuroxime)." Glaxo Wellcome (2002):
  15. "Product Information. Keflex (cephalexin)." Dista Products Company (2002):
  16. "Product Information. Cedax (ceftibuten)." Schering-Plough (2001):
  17. "Product Information. Maxipime (cefepime)." Bristol-Myers Squibb (2001):
  18. "Product Information. Omnicef (cefdinir)." Parke-Davis (2001):
  19. "Product Information. Ceclor CD (cefaclor)." Dura Pharmaceuticals (2001):
  20. "Product Information. Spectracef (cefditoren)." TAP Pharmaceuticals Inc (2001):