Diphenhydramine Hydrochloride + Zinc Acetate interactions
Checked as Diphenhydramine + Zinc acetate in this data source.
Full monograph for Diphenhydramine Hydrochloride + Zinc AcetateCheck it against another medicine
Medicines
384 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Brexpiprazolevia Diphenhydramine | Major | Metabolism | Coadministration with inhibitors of CYP450 3A4 and/or 2D6 may significantly increase the plasma concentrations of brexpiprazole, which is metabolized by these… | 5 sources — open the full entry |
| Potassium Chloridevia Diphenhydramine | Major | Absorption | Concomitant use of agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants… | 15 sources — open the full entry |
| Potassium Citratevia Diphenhydramine | Major | Synergy | Concomitant use of agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants… | 15 sources — open the full entry |
| Potassium Citrate + Citric Acidvia Diphenhydramine | Major | Synergy | Concomitant use of agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants… | 15 sources — open the full entry |
| Sodium Chloride + Potassium Chloride + Sodium Acetatevia Diphenhydramine | Major | Absorption | Concomitant use of agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants… | 15 sources — open the full entry |
| Tamoxifen Citratevia Diphenhydramine | Major | Metabolism | Chronic coadministration of potent or moderate CYP450 2D6 inhibitors including certain antidepressants may reduce the effectiveness of tamoxifen. The proposed… | 35 sources — open the full entry |
| Topiramatevia Diphenhydramine | Major | Synergy | Certain drugs such as carbonic anhydrase inhibitors and drugs with anticholinergic activity (e.g., antihistamines, antispasmodics, neuroleptics… | 9 sources — open the full entry |
| Zonisamidevia Diphenhydramine | Major | Synergy | Certain drugs such as carbonic anhydrase inhibitors and drugs with anticholinergic activity (e.g., antihistamines, antispasmodics, neuroleptics… | 9 sources — open the full entry |
| Abiraterone Acetatevia Diphenhydramine | Moderate | Metabolism | Coadministration with abiraterone acetate may increase the plasma concentrations of drugs that are substrates of the CYP450 2D6 isoenzyme. The mechanism is… | 6 sources — open the full entry |
| Aclidinium Bromide + Formoterol Fumaratevia Diphenhydramine | Moderate | Synergy | The potential exists for additive anticholinergic effects such as mydriasis, blurred vision, heat intolerance, fever, dry mouth, tachycardia, urinary… | 12 sources — open the full entry |
| Alendronic acidvia Zinc acetate | Moderate | Absorption | INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to… | 9 sources — open the full entry |
| Alendronic Acid + Vitamin D3via Zinc acetate | Moderate | Absorption | INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to… | 9 sources — open the full entry |
| Alfuzosin Hydrochloridevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Alprazolamvia Diphenhydramine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Amantadine Hydrochloridevia Diphenhydramine | Moderate | Synergy | The anticholinergic-like adverse effects of amantadine may be potentiated by agents with anticholinergic properties such as antihistamines, antispasmodics… | 6 sources — open the full entry |
| Amiodarone Hydrochloridevia Diphenhydramine | Moderate | Synergy | The use of higher than recommended dosages of diphenhydramine (e.g., through abuse or misuse) has been associated with serious and potentially fatal cardiac… | 8 sources — open the full entry |
| Amitriptyline Hydrochloridevia Diphenhydramine | Moderate | Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic… | 19 sources — open the full entry |
| Amitriptyline Hydrochloride + Chlordiazepoxidevia Diphenhydramine | Moderate | Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 63 sources — open the full entry |
| Amlodipine Besilatevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 7 sources — open the full entry |
| Amlodipine Besilate + Atenololvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 18 sources — open the full entry |
| Amlodipine Besilate + Atorvastatinvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 7 sources — open the full entry |
| Amlodipine Besilate + Benazepril Hydrochloridevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 18 sources — open the full entry |
| Amlodipine Besilate + Olmesartan Medoxomilvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 18 sources — open the full entry |
| Amlodipine Besilate + Telmisartanvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 18 sources — open the full entry |
| Amlodipine Besilate + Valsartanvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 7 sources — open the full entry |
| Aripiprazolevia Diphenhydramine | Moderate | Antagonism | Centrally-acting anticholinergic agents may antagonize the therapeutic effects of neuroleptic agents. Although these drugs have been used together clinically… | 21 sources — open the full entry |
| Asenapine Maleatevia Diphenhydramine | Moderate | Antagonism | Centrally-acting anticholinergic agents may antagonize the therapeutic effects of neuroleptic agents. Although these drugs have been used together clinically… | 21 sources — open the full entry |
| Atenololvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Atenolol + Chlorthalidonevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 18 sources — open the full entry |
| Atomoxetine Hydrochloridevia Diphenhydramine | Moderate | Metabolism | Coadministration with drugs that are inhibitors of CYP450 2D6 may increase the plasma concentrations of atomoxetine, which is primarily metabolized by the… | 3 sources — open the full entry |
| Atropine Sulfate (Injection)via Diphenhydramine | Moderate | Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic… | 19 sources — open the full entry |
| Azilsartan Medoxomilvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 18 sources — open the full entry |
| Azilsartan Medoxomil + Chlorthalidonevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…3 documented mechanisms | 18 sources — open the full entry |
| Baclofenvia Diphenhydramine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Baloxavir Marboxilvia Zinc acetate | Moderate | Absorption | Coadministration with polyvalent cation-containing products may decrease the plasma concentrations and therapeutic efficacy of baloxavir. The proposed… | 3 sources — open the full entry |
| Beclometasone + Formoterol + Glycopyrroniumvia Diphenhydramine | Moderate | Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic… | 19 sources — open the full entry |
| Betaxolol Hydrochloridevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Bimatoprost + Timololvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Bisoprolol Fumaratevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Bisoprolol Fumarate + Amlodipine Besilatevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 18 sources — open the full entry |
| Bisoprolol Fumarate + Hydrochlorothiazidevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 18 sources — open the full entry |
| Brimonidine Tartrate + Timolol Maleatevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Brinzolamide + Timololvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Brivaracetamvia Diphenhydramine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Bromocriptine Mesylatevia Diphenhydramine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Budesonide + Glycopyrronium Bromide + Formoterol Fumaratevia Zinc acetate, Diphenhydramine | Moderate | Antagonism · Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 23 sources — open the full entry |
| Bumetanidevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 11 sources — open the full entry |
| Bupropion Hydrochloridevia Diphenhydramine | Moderate | Metabolism | Coadministration with bupropion may increase the plasma concentrations of drugs that are metabolized by CYP450 2D6 (e.g., selective serotonin reuptake… | 15 sources — open the full entry |
| Candesartan Cilexetilvia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… | 7 sources — open the full entry |
| Candesartan Cilexetil + Hydrochlorothiazidevia Diphenhydramine | Moderate | Synergy | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…2 documented mechanisms | 7 sources — open the full entry |
Food & lifestyle
alcohol
ModerateSynergy
Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system.
What to do: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
1 source
- Linnoila M "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol 6 (1973): 107-12
bran
ModerateAbsorption
The presence of certain foods (e.g., bread, bran, hard boiled eggs, coffee, and milk) may significantly delay the absorption of zinc acetate. Fibres, phytates, and other substances in food prevent zinc from entering intestinal cells by binding with it. Protein does not appear to interfere with its absorption.
What to do: Zinc acetate should preferably be taken on an empty stomach, at least one hour before or two to three hours after meals. It may be taken with small amounts of protein such as meat.
1 source
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
coffee
ModerateAbsorption
The presence of certain foods (e.g., bread, bran, hard boiled eggs, coffee, and milk) may significantly delay the absorption of zinc acetate. Fibres, phytates, and other substances in food prevent zinc from entering intestinal cells by binding with it. Protein does not appear to interfere with its absorption.
What to do: Zinc acetate should preferably be taken on an empty stomach, at least one hour before or two to three hours after meals. It may be taken with small amounts of protein such as meat.
1 source
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
dairy products
ModerateAbsorption
The presence of certain foods (e.g., bread, bran, hard boiled eggs, coffee, and milk) may significantly delay the absorption of zinc acetate. Fibres, phytates, and other substances in food prevent zinc from entering intestinal cells by binding with it. Protein does not appear to interfere with its absorption.
What to do: Zinc acetate should preferably be taken on an empty stomach, at least one hour before or two to three hours after meals. It may be taken with small amounts of protein such as meat.
1 source
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Conditions
Conditions in which Diphenhydramine Hydrochloride + Zinc Acetate needs care, as documented in this source.
Kidney Diseases
ModerateThe trace metals, chromium and zinc, are excreted primarily in the urine. Selenium is partially excreted in the urine. Supplemental doses of these agents may need to be adjusted, reduced, or omitted in patients with renal dysfunction.
3 sources
- "Product Information. Galzin (zinc acetate)." Teva Pharmaceuticals USA (2001):
- "Product Information. Chroma-Pak (chromic chloride hexahydrate)." Apothecon Inc (2022):
- "Product Information. Sele-Pak (selenium)." Fujisawa
Malabsorption Syndromes
ModerateThe trace metals manganese, chromium, copper, selenium, and zinc are absorbed in the GI tract from dietary sources and following administration of oral supplements. GI absorption may be decreased in patients with malabsorption syndromes. Therefore, larger dosages may be required when these supplements are given orally. Parenteral administration may be appropriate.
6 sources
- "Product Information. Galzin (zinc acetate)." Teva Pharmaceuticals USA (2001):
- "Product Information. Chroma-Pak (chromic chloride hexahydrate)." Apothecon Inc (2022):
- "Product Information. Sele-Pak (selenium)." Fujisawa
- "Product Information. Copper Sulfate (copper sulfate)." Humco Holding Group (2001):
- "Product Information. Manganese Chloride (manganese chloride)." Abbott Pharmaceutical (2001):
- "Product Information. Manganese Sulfate (manganese sulfate)." American Regent Laboratories Inc (2001):
Therapeutic duplication
Drug classes that overlap with Diphenhydramine Hydrochloride + Zinc Acetate, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
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The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
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The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
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The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
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The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
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The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Pseudoephedrine/triprolidine
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Betatan
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Vicks nyquil cough
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Sinarest
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Chlorpheniramine/ibuprofen/phenylephrine
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Vanacof
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Histex-ac
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Poly hist forte
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Rynex pe
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Chlorpheniramine/phenylephrine
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Vicks nyquil d cold and flu nighttime relief
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Flextra
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Phenylephrine/promethazine
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Promethazine dm
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Pro-chlo
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): All day allergy-d