Dobutamine Hydrochloride interactions
Checked as Dobutamine in this data source.
Full monograph for Dobutamine HydrochlorideCheck it against another medicine
Medicines
208 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Amitriptyline Hydrochloride | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Amitriptyline Hydrochloride + Chlordiazepoxide | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Clomipramine Hydrochloride | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Doxepin (Oral) | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Fluphenazine + Nortriptyline | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Imipramine Hydrochloride | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Linezolid | Major | Synergy | Linezolid may potentiate the pressor response to sympathomimetic agents. Linezolid is a reversible, nonselective monoamine oxidase inhibitor (MAOI) and, as… | 24 sources — open the full entry |
| Nortriptyline | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Acarbose | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Aclidinium Bromide + Formoterol Fumarate | Moderate | Synergy | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists… | 11 sources — open the full entry |
| Alogliptin Benzoate | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Amlodipine Besilate + Atenolol | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Arformoterol Tartrate | Moderate | Synergy | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists… | 11 sources — open the full entry |
| Atenolol | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Atenolol + Chlorthalidone | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Atomoxetine Hydrochloride | Moderate | Synergy | Central nervous system (CNS) stimulants, particularly the amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic… | 10 sources — open the full entry |
| Beclometasone + Formoterol + Glycopyrronium | Moderate | Synergy | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists… | 11 sources — open the full entry |
| Beclomethasone Dipropionate + Formoterol Fumarate | Moderate | Synergy | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists… | 11 sources — open the full entry |
| Betaxolol Hydrochloride | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Bimatoprost + Timolol | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Biphasic Insulin Aspart | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Bisoprolol Fumarate | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Bisoprolol Fumarate + Amlodipine Besilate | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Bisoprolol Fumarate + Hydrochlorothiazide | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Brimonidine Tartrate + Timolol Maleate | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Brinzolamide + Timolol | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Budesonide + Formoterol Fumarate | Moderate | Synergy | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists… | 11 sources — open the full entry |
| Budesonide + Glycopyrronium Bromide + Formoterol Fumarate | Moderate | Synergy | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists… | 11 sources — open the full entry |
| Bupropion Hydrochloride | Moderate | Synergy | Translated with DeepL | 4 sources — open the full entry |
| Canagliflozin Hemihydrate | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Carbidopa + LevodopaExtended releaseProlonged release | Moderate | Synergy | Coadministration with levodopa may potentiate the cardiovascular effects of sympathomimetic agents (e.g., epinephrine, norepinephrine, isoproterenol… | 6 sources — open the full entry |
| Carvedilol | Moderate | Synergy | A case of marked hypotension resulting from concomitant use of low dose carvedilol with dobutamine has been reported. The mechanism may be related to a… | 2 sources — open the full entry |
| Dapagliflozin Propanediol | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Desmopressin Acetate | Moderate | Synergy | Concomitant use of vasopressin or desmopressin with catecholamines is expected to result in an additive effect on mean arterial blood pressure and other… | 16 sources — open the full entry |
| Desvenlafaxine Succinate | Moderate | Synergy | Additive or synergistic effects on blood pressure and heart rate may occur when serotonin-norepinephrine reuptake inhibitors (SNRIs) are combined with… | 12 sources — open the full entry |
| Dextromethorphan + Bupropion | Moderate | Synergy | Translated with DeepL | 4 sources — open the full entry |
| Digoxin | Moderate | Synergy | The concomitant use of sympathomimetic agents and cardiac glycosides may increase the risk of cardiac arrhythmias. The mechanism of this interaction is not… | 11 sources — open the full entry |
| Dorzolamide + Timolol | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Dulaglutide | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Duloxetine Hydrochloride | Moderate | Synergy | Additive or synergistic effects on blood pressure and heart rate may occur when serotonin-norepinephrine reuptake inhibitors (SNRIs) are combined with… | 12 sources — open the full entry |
| Empagliflozin | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Empagliflozin + Linagliptin | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Empagliflozin + Metformin Hydrochloride | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
| Ertugliflozin | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Esmolol Hydrochloride | Moderate | Antagonism | Beta-blockers may antagonize the cardiostimulatory effects of pressor agents by blocking beta-1 adrenergic receptors in the heart. Vasopressors may be less… | 3 sources — open the full entry |
| Fluticasone Propionate + Formoterol Fumarate | Moderate | Synergy · Unknown | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists…2 documented mechanisms | 11 sources — open the full entry |
| Formoterol Fumarate + Glycopyrrolate + Budesonide | Moderate | Synergy | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists… | 11 sources — open the full entry |
| Glibenclamide | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Glimepiride | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Glimepiride + Metformin | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 95 sources — open the full entry |
Conditions
Conditions in which Dobutamine Hydrochloride needs care, as documented in this source.
Arrhythmias, Cardiac
MajorDobutamine and arbutamine produce stimulation of the beta receptors of the heart. The use of these agents has been associated with an increase in heart rate, ventricular ectopy, atrial fibrillation, hypertension, enhanced A-V conduction, and arrhythmias. Therapy with dobutamine or arbutamine should be administered cautiously in patients with cardiac conduction disorders.
10 sources
- Bianchi C, Diaz R, Gonzales C, Beregovich J "Effects of dobutamine on atrioventricular conduction." Am Heart J 90 (1975): 474-8
- "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company (2002):
- Baudhuin T, Marwick T, Melin J, Wijns W, D'Hondt AM, Detry JM "Diagnosis of coronary artery disease in elderly patients: safety and efficacy of dobutamine echocardiography." Eur Heart J 14 (1993): 799-803
- Poldermans D, Fioretti PM, Boersma E, Forster T, Vanurk H, Cornel JH, Arnese M, Roelandt JRTC "Safety of dobutamine-atropine stress echocardiography in patients with suspected or proven coronary artery disease." Am J Cardiol 73 (1994): 456-9
- Picano E, Mathias W, Pingitore A, Bigi R, Previtali M "Safety and tolerability of dobutamine-atropine stress echocardiography: a prospective, multicentre study." Lancet 344 (1994): 1190-2
- Kinder C, Chamberlain J, Kall J, Kopp D, Johnson M, Costanzo MR, Wilber D "Prognostic significance of sustained ventricular tachyarrhythmia occurring during dobutamine infusion." J Heart Lung Transplant 13 (1994): 1045-50
- Cohen A, Chauvel C, Benhalima B, Blanchard B "Complication of dobutamine stress echocardiography." Lancet 345 (1995): 201-2
- Tisdale JE, Patel R, Webb CR, Borzak S, Zarowitz BJ "Electrophysiologic and proarrhythmic effects of intravenous inotropic agents." Prog Cardiovasc Dis 38 (1995): 167-80
Show all 10 sourcesShow fewer sources
- Previtali M, Lanzarini L, Fetiveau R, Poli A, Diotallevi P "Dobutamine-induced and spontaneous sustained ventricular tachycardia in recent myocardial infarction." Eur Heart J 17 (1996): 803-4
- "Product Information. GenESA (arbutamine)." Gensia Inc (2001):
Asthma
MajorDobutamine injection contains sodium metabisulfite, a sulfite that may cause anaphylactic symptoms and life-threatening or less severe asthmatic episodes in susceptible people, such as asthmatic patients.
1 source
- "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company (2002):
Cardiomyopathy, Hypertrophic
MajorThe use of dobutamine or arbutamine is contraindicated in patients with idiopathic hypertrophic subaortic stenosis (IHSS). Dobutamine or arbutamine may increase the pressure gradient within the left ventricle and thereby worsen cardiac output in patients with IHSS.
2 sources
- "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company (2002):
- "Product Information. GenESA (arbutamine)." Gensia Inc (2001):
Hypotension
MajorThe use of dobutamine and arbutamine has been infrequently associated with significant hypotension especially in dehydrated patients secondary to beta-2 mediated vasodilation. Hypovolemia should be corrected before administering dobutamine or arbutamine. Blood pressure and ECG should be monitored at regular intervals. Monitoring of cardiac output and pulmonary wedge pressure may also be desired.
4 sources
- Rosamond TL, Vacek JL, Hurwitz A, Rowland AJ, Beauchamp GD, Crouse LJ "Hypotension during dobutamine stress echocardiography: initial description and clinical relevance." Am Heart J 123 (1992): 403-7
- "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company (2002):
- Heinle SK, Tice FD, Kisslo J "Hypotension during dobutamine stress echocardiography: is it related to dynamic intraventricular obstruction?" Am Heart J 130 (1995): 314-7
- "Product Information. GenESA (arbutamine)." Gensia Inc (2001):
Hypokalemia
ModerateThe use of dobutamine has been associated with hypokalemia. Therapy with dobutamine should be administered cautiously to patients with hypokalemia. Frequent monitoring of serum potassium along with appropriate electrolyte replacement is recommended.
1 source
- "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company (2002):
Therapeutic duplication
Drug classes that overlap with Dobutamine Hydrochloride, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
sympathomimetic amines
The recommended maximum number of medicines in the 'sympathomimetic amines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'sympathomimetic amines' category.
Example product in the source data (US market): Guaifenex