Hydroxocobalamin interactions
Full monograph for HydroxocobalaminCheck it against another medicine
Medicines
68 documented
Mechanism
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Arsenic Trioxide | Moderate | Synergy | Arsenic trioxide can cause QT interval prolongation and complete atrioventricular block. Theoretically, use of arsenic trioxide during intensive vitamin B12… | 3 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocaine | Moderate | Antagonism | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12… | 3 sources — open the full entry |
| Chloramphenicol (Oral) | Moderate | Antagonism | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12… | 3 sources — open the full entry |
| Chloramphenicol + Lidocaine Hydrochloride | Moderate | Antagonism | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12… | 3 sources — open the full entry |
| Dexamethasone + Chloramphenicol | Moderate | Antagonism | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12… | 3 sources — open the full entry |
Conditions
Conditions in which Hydroxocobalamin needs care, as documented in this source.
Hypokalemia
MajorHypokalemia (resulting in death) has occurred during vitamin B12 therapy as a result of increased red blood cell requirements during hematopoiesis. Clinical monitoring and correction of potassium levels prior to and during vitamin B12 therapy is necessary.
2 sources
- "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
- "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc (2001):
Optic Atrophy, Hereditary, Leber
MajorThe use of cyanocobalamin is contraindicated in patients with Leber's disease (hereditary optic nerve atrophy). Cyanocobalamin has induced severe and rapid optic nerve atrophy in patient's with early Leber's disease.
2 sources
- "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
- "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc (2001):
Malabsorption Syndromes
ModerateAbsorption of vitamin B12 is decreased in malabsorption syndromes and in pernicious anemia without coadministration of intrinsic factor (IF). Cyanocobalamin is rapidly absorbed following IM or subcutaneous injections. Hydroxocobalamin (cyanocobalamin analog) functions the same a cyanocobalamin, but has induced antibody formation to the hydroxocobalamin-transcobalamin II complex. The use of cyanocobalamin may be preferred in patients with these conditions.
1 source
- "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc (2001):