Imipenem + Cilastatin interactions
Checked as Imipenem in this data source.
Full monograph for Imipenem + CilastatinCheck it against another medicine
Medicines
33 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Bupropion Hydrochloride | Major | Synergy | The use of bupropion is associated with a dose-related risk of seizures. The risk may be further increased when coadministered with selective serotonin… | 19 sources — open the full entry |
| Dextromethorphan + Bupropion | Major | Synergy | The use of bupropion is associated with a dose-related risk of seizures. The risk may be further increased when coadministered with selective serotonin… | 19 sources — open the full entry |
| Iohexol | Major | Synergy | Intrathecal administration of iodinated contrast media may induce seizures. Although clinical data are generally lacking, there may be a theoretical risk of… | 5 sources — open the full entry |
| Iopamidol | Major | Synergy | Intrathecal administration of iodinated contrast media may induce seizures. Although clinical data are generally lacking, there may be a theoretical risk of… | 5 sources — open the full entry |
| Paracetamol + Tramadol Hydrochloride | Major | Synergy | The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin… | 8 sources — open the full entry |
| Sodium Valproate | Major | Others | Coadministration with carbapenem antibiotics may substantially decrease the serum concentrations of valproic acid (VPA) and increase the risk of breakthrough… | 36 sources — open the full entry |
| Tramadol Hydrochloride | Major | Synergy | The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin… | 8 sources — open the full entry |
| Aminophylline | Moderate | Synergy | Some case reports suggest an increased risk of seizures when theophylline and imipenem are coadministered. The mechanism is unknown. Patients receiving large… | 4 sources — open the full entry |
| Cyclosporine (Oral) | Moderate | Synergy | Limited data suggest that the neurotoxic effects of imipenem and cyclosporine may be additive. The mechanism is unknown but may be due to additive CNS effects. | 16 sources — open the full entry |
| Cyproterone Acetate + Ethinyl Estradiol | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Dienogest + Estradiol Valerate | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Estradiol | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol0.02 mg0.03 mg | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol + Levomefolate | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Entecavir Monohydrate | Moderate | Excretion | Coadministration of entecavir with another drug that is also eliminated by active tubular secretion may result in increased plasma concentrations of one or… | 2 sources — open the full entry |
| Estradiolbasevaginal cream | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol + Dydrogesterone | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol Hemihydrate + Progesterone Micronized | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol Valerate | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Desogestrel0.02 mg0.03 mg | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Gestodene | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Levonorgestrel + Ferrous Fumarate | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Lynestrenol0.0375 mg0.05 mg | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Fluphenazine + Nortriptyline | Moderate | Synergy | The risk of seizures may be increased during coadministration of fluphenazine with any substance that can reduce the seizure threshold, such as aminophylline… | 2 sources — open the full entry |
| Fluphenazine Decanoate | Moderate | Synergy | The risk of seizures may be increased during coadministration of fluphenazine with any substance that can reduce the seizure threshold, such as aminophylline… | 2 sources — open the full entry |
| Ganciclovir | Moderate | Synergy | According to the product labeling for ganciclovir and imipenem-cilastatin, generalized seizures have occurred in patients receiving these agents together. The… | 4 sources — open the full entry |
| Mycophenolate Mofetil | Moderate | Absorption | Theoretically, drugs that alter the gastrointestinal flora (e.g., antibiotics) may reduce the oral bioavailability of mycophenolic acid products. Some… | 3 sources — open the full entry |
| Mycophenolic acid | Moderate | Absorption | Theoretically, drugs that alter the gastrointestinal flora (e.g., antibiotics) may reduce the oral bioavailability of mycophenolic acid products. Some… | 3 sources — open the full entry |
| Norgestrel + Ethinyl Estradiol + Ferrous Fumarate | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Pemetrexed | Moderate | Excretion | Coadministration with drugs that are eliminated by active tubular secretion may delay and/or decrease the clearance of pemetrexed. The mechanism is competitive… | 1 sources — open the full entry |
| Relugolix + Estradiol + Norethindrone | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Theophylline | Moderate | Synergy | Some case reports suggest an increased risk of seizures when theophylline and imipenem are coadministered. The mechanism is unknown. Patients receiving large… | 4 sources — open the full entry |
| Warfarin Sodium | Moderate | Synergy | Anti-bacterial agents may potentiate the anticoagulant effects of orally administered vitamin K antagonists, including warfarin. Possible mechanisms include… | 38 sources — open the full entry |
This source documents no food, condition or duplication entries for Imipenem + Cilastatin.