Isotretinoin (Topical) interactions
Full monograph for Isotretinoin (Topical)Check it against another medicine
Medicines
104 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Acitretin | Major | Synergy | Concomitant use of a retinoid with vitamin A or other retinoids may result in hypervitaminosis A and additive toxicities. Patients may be at increased risk for… | 5 sources — open the full entry |
| Clindamycin + Tretinoin | Major | Synergy | Concomitant use of a retinoid with vitamin A or other retinoids may result in hypervitaminosis A and additive toxicities. Patients may be at increased risk for… | 5 sources — open the full entry |
| Doxycycline Hydrochloride | Major | Synergy | Concomitant use of vitamin A or related compounds (i.e., retinoids) with tetracyclines may increase the risk of pseudotumor cerebri, also known as benign… | 25 sources — open the full entry |
| Fluocinolone Acetonide + Hydroquinone + Tretinoin | Major | Synergy | Concomitant use of a retinoid with vitamin A or other retinoids may result in hypervitaminosis A and additive toxicities. Patients may be at increased risk for… | 5 sources — open the full entry |
| Iron + Folic Acid + Vitamin A + Vitamin C + Zinc | Major | Synergy | Concomitant use of a retinoid with vitamin A or other retinoids may result in hypervitaminosis A and additive toxicities. Patients may be at increased risk for… | 5 sources — open the full entry |
| Leflunomide | Major | Synergy | The recent, concomitant, or subsequent use (without the recommended leflunomide washout period or procedure) of other agents known to induce hepatotoxicity may… | 3 sources — open the full entry |
| Minocycline Hydrochloride | Major | Synergy | Concomitant use of vitamin A or related compounds (i.e., retinoids) with tetracyclines may increase the risk of pseudotumor cerebri, also known as benign… | 25 sources — open the full entry |
| Oxytetracycline | Major | Synergy | Concomitant use of vitamin A or related compounds (i.e., retinoids) with tetracyclines may increase the risk of pseudotumor cerebri, also known as benign… | 25 sources — open the full entry |
| Oxytetracycline + Polymixin B Sulphate | Major | Synergy | Concomitant use of vitamin A or related compounds (i.e., retinoids) with tetracyclines may increase the risk of pseudotumor cerebri, also known as benign… | 25 sources — open the full entry |
| Tetracycline Hydrochloride | Major | Synergy | Concomitant use of vitamin A or related compounds (i.e., retinoids) with tetracyclines may increase the risk of pseudotumor cerebri, also known as benign… | 25 sources — open the full entry |
| Tretinoin (Oral) | Major | Synergy | Concomitant use of a retinoid with vitamin A or other retinoids may result in hypervitaminosis A and additive toxicities. Patients may be at increased risk for… | 5 sources — open the full entry |
| Vitamin A | Major | Synergy | Concomitant use of a retinoid with vitamin A or other retinoids may result in hypervitaminosis A and additive toxicities. Patients may be at increased risk for… | 5 sources — open the full entry |
| Abametapir | Moderate | Metabolism | Based on in vitro inhibition data, a single topical application of abametapir lotion may increase plasma concentrations of drugs that are substrates of CYP450… | 1 sources — open the full entry |
| Abiraterone Acetate | Moderate | Metabolism | Coadministration with abiraterone acetate may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 2C8. Abiraterone is a potent… | 4 sources — open the full entry |
| Acyclovir + Hydrocortisone | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Adapalene + Benzoyl peroxide | Moderate | Synergy | Concomitant use of isotretinoin with topical exfoliative or keratolytic anti-acne agents may increase local skin irritation. | 2 sources — open the full entry |
| Alpelisib | Moderate | Metabolism | Coadministration with alpelisib may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 2C9, such as warfarin… | 36 sources — open the full entry |
| Apalutamide | Moderate | Absorption · Metabolism | Coadministration with apalutamide may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 3A4, 2C9, 2C19, breast… | 5 sources — open the full entry |
| Asciminib | Moderate | Metabolism | Coadministration with asciminib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 2C9 isoenzyme. The mechanism is… | 1 sources — open the full entry |
| Benzoyl Peroxide | Moderate | Synergy | Concomitant use of isotretinoin with topical exfoliative or keratolytic anti-acne agents may increase local skin irritation. | 2 sources — open the full entry |
| Betamethasone | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone + Calcipotriol | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone + Clotrimazole | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone + Neomycin Sulphate (Ophthalmic) | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone + Phenylephrine + Lignocaine | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone Dipropionate | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone Dipropionate + Salicylic Acid | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone Sodium Phosphate | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Betamethasone Valerate | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| BudesonideInhalerNebuliser SuspensionTablet | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Budesonide + Formoterol Fumarate | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Budesonide + Glycopyrronium Bromide + Formoterol Fumarate | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Calcium Dobesilate + Lidocaine + Dexamethasone | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Carbamazepine | Moderate | Antagonism | A case report has suggested that isotretinoin may decrease the AUC of carbamazepine. Pharmacologic effects may be reduced. The mechanism is unknown. | 4 sources — open the full entry |
| Cenobamate | Moderate | Metabolism | Coadministration with cenobamate may decrease the plasma concentrations and pharmacologic effects of CYP450 3A4 substrates. The proposed mechanism is… | 1 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Framycetin + Esculin | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Neomycin + Esculin | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Ciprofloxacin + Dexamethasone | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Clindamycin + Benzoyl peroxide | Moderate | Synergy | Concomitant use of isotretinoin with topical exfoliative or keratolytic anti-acne agents may increase local skin irritation. | 2 sources — open the full entry |
| Clotrimazole + Hydrocortisone | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Deflazacort | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Dexamethasone | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Dexamethasone + Chloramphenicol | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Dexamethasone + Levofloxacin | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Dexamethasone + Neomycin + Glacial Acetic Acid | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Dexamethasone + Neomycin Sulphate + Polymyxin B Sulphate | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Dexamethasone + Tobramycin | Moderate | Synergy | Theoretical concerns exist that isotretinoin and corticosteroids may have additive effects on bone loss. Decreased bone mineral density (osteomalacia… | 19 sources — open the full entry |
| Drospirenone | Moderate | Others | Isotretinoin may decrease the plasma concentrations of contraceptive progestins. The potential mechanism of interaction has not been established. | 2 sources — open the full entry |
| Drospirenone + Estetrol | Moderate | Others | Isotretinoin may decrease the plasma concentrations of contraceptive progestins. The potential mechanism of interaction has not been established. | 2 sources — open the full entry |
Food & lifestyle
alcohol
ModerateMetabolism
The combined use of ethanol and isotretinoin may result in a disulfiram-like reaction.
What to do: Alcohol consumption should be avoided during isotretinoin therapy.
1 source
- "Product Information. Accutane (isotretinoin)." Roche Laboratories (2001):
Conditions
Conditions in which Isotretinoin (Topical) needs care, as documented in this source.
Intracranial Hypertension
MajorThe use of retinoids has been associated with cases of pseudotumor cerebri (benign intracranial hypertension). Early signs and symptoms include papilledema, headache, nausea and vomiting, and visual disturbances. Patients who experience symptoms of this disorder while on retinoid therapy should be referred to a neurologist. If the diagnosis is confirmed, the retinoid should be discontinued permanently.
2 sources
- "Product Information. Accutane (isotretinoin)." Roche Laboratories (2001):
- "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):
Mental Disorders
MajorThe use of retinoids, primarily isotretinoin, has been associated with causing depression, psychosis and rarely, suicidal ideation. Therapy with retinoids should be administered cautiously in patients with preexisting psychiatric conditions or depression. In addition to withdrawal of therapy, evaluation and follow-up may be necessary in affected patients.
2 sources
- "Product Information. Accutane (isotretinoin)." Roche Laboratories (2001):
- "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):
Hyperlipidemias
ModerateThe use of retinoids is associated with elevations in serum triglycerides and cholesterol, and decreases in HDL. In addition to cardiovascular risks, elevation of serum triglycerides to greater than 800 mg/dL has been associated with fatal fulminant pancreatitis. Patients at increased risk for developing hypertriglyceridemia during retinoid therapy include those with diabetes mellitus, obesity, high alcohol consumption, or a family history of these conditions. Blood lipid determinations should be performed prior to initiation of therapy and at 1- to 2- week intervals until the lipid response to the drug is established (usually 4 to 8 weeks). Patients with preexisting hyperlipidemia may require closer monitoring during retinoid therapy, and adjustments made accordingly in their lipid-lowering regimen.
1 source
- "Product Information. Accutane (isotretinoin)." Roche Laboratories (2001):
Liver Diseases
ModerateThe use of retinoids has been associated with elevations in liver enzymes and toxic hepatitis. Therapy with retinoids should be administered cautiously in patients with liver disease. Monitoring liver enzymes is recommended in these patients.
2 sources
- "Product Information. Accutane (isotretinoin)." Roche Laboratories (2001):
- "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):
Osteoporosis
ModerateIsotretinoin may have a negative effect on bone mineral density in some patients. Clinical trials have shown BMD declines in adolescents during a 20 week treatment. Therefore, physicians should use caution when prescribing isotretinoin in patients with a history of childhood osteoporosis, osteomalacia, or other disorders of bone metabolism.
1 source
- "Product Information. Accutane (isotretinoin)." Roche Laboratories (2001):
Therapeutic duplication
Drug classes that overlap with Isotretinoin (Topical), so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
retinoic acid derivatives
The recommended maximum number of medicines in the 'retinoic acid derivatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'retinoic acid derivatives' category.
Example product in the source data (US market): Triderma
retinoic acid derivatives
The recommended maximum number of medicines in the 'retinoic acid derivatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'retinoic acid derivatives' category.
Example product in the source data (US market): Olivia quido firm and fade
retinoic acid derivatives
The recommended maximum number of medicines in the 'retinoic acid derivatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'retinoic acid derivatives' category.
Example product in the source data (US market): Halobetasol/tazarotene (topical)