Lactic Acid interactions
Full monograph for Lactic AcidCheck it against another medicine
Medicines
33 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Aspirin | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Aspirin + Dipyridamole | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Benzoic Acid + Salicylic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Betamethasone Dipropionate + Salicylic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Cetalkonium Chloride + Choline Salicylate | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Clobetasol Propionate + Salicylic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Clopidogrel + Aspirin | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Coal Tar + Precipitated Sulphur + Salicylic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Dextromethorphan + Pseudoephedrine + Triprolidine | Moderate | Excretion | Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. Toxicity from… | 3 sources — open the full entry |
| Dithranol + Boric Acid + Salicylic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Doxycycline Hydrochloride | Moderate | Excretion | INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve… | 5 sources — open the full entry |
| Ephedrine Hydrochloride | Moderate | Excretion | Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. Toxicity from… | 3 sources — open the full entry |
| Lithium Carbonate | Moderate | Others | Urinary alkalinizers may increase excretion of lithium. Plasma lithium levels and therapeutic effects may be decreased. | 8 sources — open the full entry |
| Loratadine + Pseudoephedrine | Moderate | Excretion | Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. Toxicity from… | 3 sources — open the full entry |
| Malic Acid + Benzoic acid + Salicylic acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Methenamine Hippurate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Minocycline Hydrochloride | Moderate | Excretion | INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve… | 5 sources — open the full entry |
| Mucopolysaccharide Polysulphate + Salicylic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Oxytetracycline | Moderate | Excretion | INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve… | 5 sources — open the full entry |
| Oxytetracycline + Polymixin B Sulphate | Moderate | Excretion | INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve… | 5 sources — open the full entry |
| Pseudoephedrine + Guaiphenasine + Triprolidine | Moderate | Excretion | Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. Toxicity from… | 3 sources — open the full entry |
| Rhubarb Extract + Salicylic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Salicylic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Salicylic Acid + Lactic Acid | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Salicylic acid + Zinc Pyrithione | Moderate | Excretion | Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other… | 5 sources — open the full entry |
| Tetracycline Hydrochloride | Moderate | Excretion | INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve… | 5 sources — open the full entry |
| Flecainide Acetate | Minor | Excretion | Agents that alkalinize the urine decrease the renal elimination of flecainide. The result may be increased plasma flecainide levels and increased… | 1 sources — open the full entry |
| Glibenclamide | Minor | Excretion | Alkalinization of the urine may increase the renal clearance of some sulfonylureas for which renal elimination is pH dependent. The clinical significance of… | 12 sources — open the full entry |
| Glipizide | Minor | Excretion | Alkalinization of the urine may increase the renal clearance of some sulfonylureas for which renal elimination is pH dependent. The clinical significance of… | 12 sources — open the full entry |
| Glipizide + Metformin Hydrochloride | Minor | Excretion | Alkalinization of the urine may increase the renal clearance of some sulfonylureas for which renal elimination is pH dependent. The clinical significance of… | 12 sources — open the full entry |
| Memantine + Donepezil | Minor | Excretion | The concomitant administration of memantine and drugs that alkalinize the urine may decrease the clearance of memantine, resulting in accumulation of memantine… | 1 sources — open the full entry |
| Memantine Hydrochloride | Minor | Excretion | The concomitant administration of memantine and drugs that alkalinize the urine may decrease the clearance of memantine, resulting in accumulation of memantine… | 1 sources — open the full entry |
| Methotrexate | Minor | Excretion | Alkalinization of the urine can increase the renal elimination of methotrexate. The pharmacologic effects of methotrexate may be decreased. No special clinical… | 4 sources — open the full entry |
Conditions
Conditions in which Lactic Acid needs care, as documented in this source.
Acidosis, Lactic
MajorLactate metabolism results in production of bicarbonate. Bicarbonate generation is impaired in patients with compromised liver function and/or disorders that decrease tissue perfusion and increase anoxia. Therapy with sodium lactate should not be used in conditions in which lactate levels are increased (e.g., shock, congestive heart failure, respiratory alkalosis) or in which utilization of lactate is diminished (e.g., anoxia, beriberi). Sodium lactate is not for use in the treatment of lactic acidosis.
1 source
- "Product Information. Sodium Lactate (sodium lactate)." Abbott Pharmaceutical (2001):
Water-Electrolyte Imbalance
MajorAlkalinizing agents containing sodium can induce sodium and water retention and result in hypernatremia, hypokalemia, hyperosmolality, edema and aggravation of congestive heart failure. Therapy with sodium- containing alkalinizing agents should not be used in patients with hypernatremia or fluid retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with alkalinizing agents is recommended.
2 sources
- "Product Information. Sodium Bicarbonate (sodium bicarbonate)." Astra-Zeneca Pharmaceuticals (2001):
- "Product Information. Sodium Lactate (sodium lactate)." Abbott Pharmaceutical (2001):
Acid-Base Imbalance
ModerateAlkalinizing agents act as proton acceptors and/or dissociate to provide bicarbonate ions. Elimination of bicarbonate is decreased in patients with renal impairment and can result in metabolic alkalosis. Symptoms of metabolic alkalosis include hyperirritability or tetany, arrhythmia, and/or seizures (altered pH = altered calcium), or lactic acidosis due to impaired oxygen release. Therapy with alkalinizing agents should be administered with extreme caution in patients with compromised renal function. Clinical monitoring of renal function, acid/base balance and electrolytes is recommended.
3 sources
- "Product Information. Urocit-K (potassium citrate)." Mission Pharmacal Company
- "Product Information. Tham (tromethamine)." Abbott Pharmaceutical (2001):
- "Product Information. Sodium Lactate (sodium lactate)." Abbott Pharmaceutical (2001):
Therapeutic duplication
Drug classes that overlap with Lactic Acid, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
systemic alkalinizing agents
The recommended maximum number of medicines in the 'systemic alkalinizing agents' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'systemic alkalinizing agents' category.
Example product in the source data (US market): Aspirin/citric acid/sodium bicarbonate