Methenamine Hippurate interactions
Checked as Methenamine in this data source.
Full monograph for Methenamine HippurateCheck it against another medicine
Medicines
49 documented
Mechanism
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Sulfasalazine | Major | Others | Some sulfonamides can form an insoluble precipitate with formaldehyde, which is generated from the hydrolysis of methenamine in acidic urine maintained by the… | 2 sources — open the full entry |
| Sulphadoxine + Pyrimethamine | Major | Others | Some sulfonamides can form an insoluble precipitate with formaldehyde, which is generated from the hydrolysis of methenamine in acidic urine maintained by the… | 2 sources — open the full entry |
| Sulphamethoxazole + Trimethoprim | Major | Others | Some sulfonamides can form an insoluble precipitate with formaldehyde, which is generated from the hydrolysis of methenamine in acidic urine maintained by the… | 2 sources — open the full entry |
| Acetazolamide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Aluminium Hydroxide + Magnesium Hydroxide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of…2 documented mechanisms | 5 sources — open the full entry |
| Aluminium Hydroxide + Magnesium Hydroxide + Simethicone | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of…2 documented mechanisms | 5 sources — open the full entry |
| Aluminium Oxide + Magnesium Trisilicate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Atenolol + Chlorthalidone | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Azilsartan Medoxomil + Chlorthalidone | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Bisoprolol Fumarate + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Calcium acetate + Magnesium carbonate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Calcium Carbonate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C + Vitamin D3 | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3 | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3 + Multiminerals | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Candesartan Cilexetil + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Chlorthalidone | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Indapamide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Indapamide + Amlodipine | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Irbesartan + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Lactic Acid | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Lactic acid + Citric acid + Potassium bitartrate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Lactic Acid + Natural Plant Extract | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Lactobacillus Rhamnosus GG | Moderate | Antagonism | Coadministration of oral probiotic preparations with oral antibiotics may reduce the efficacy of the probiotic. It has been theorized that concomitant… | 1 sources — open the full entry |
| Losartan Potassium + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Magaldrate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Magaldrate + Simethicone | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Magnesium Hydroxide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Magnesium Hydroxide + Liquid Paraffin | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Magnesium Oxide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Metolazone | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Nebivolol + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Olmesartan Medoxomil + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Perindopril + Indapamide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Potassium Citrate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Potassium Citrate + Citric Acid | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Ramipril + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Salicylic Acid + Lactic Acid | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Sodium Alginate + Sodium Bicarbonate + Calcium Carbonate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of…2 documented mechanisms | 5 sources — open the full entry |
| Sodium Bicarbonate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Sodium Bicarbonate + Citric Acid + Sodium Carbonate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Sodium Bicarbonate [Ear Preparations] | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Sodium Chloride + Potassium Chloride + Sodium Acetate | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Sodium Picosulfate + Magnesium Oxide + Citric Acid | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Telmisartan + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Triamterene + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
| Valsartan + Hydrochlorothiazide | Moderate | Antagonism | Agents that can alkalinize the urine such as thiazide diuretics, carbonic anhydrase inhibitors, and antacids may decrease the antibacterial effectiveness of… | 5 sources — open the full entry |
Conditions
Conditions in which Methenamine Hippurate needs care, as documented in this source.
Crystalluria
MajorThe use of methenamine salts (i.e. methenamine hippurate or mandelate), but not the base, is contraindicated in patients with severe renal impairment or dehydration. Methenamine is excreted by the kidney and concentrated in the urine. In patients with low urinary output, the salts can precipitate and cause crystalluria.
6 sources
- Klinge E, Mannisto P, Mantyla R, Lamminsivu U, Ottoila P "Pharmacokinetics of methenamine in healthy volunteers." J Antimicrob Chemother 9 (1982): 209-16
- Gleckman R, Alvarez S, Joubert D, Matthews S "Drug therapy reviews: methenamine mandelate and methenamine hippurate." Am J Hosp Pharm 36 (1979): 1509-12
- Australian Drug Evaluation Committee "Adverse effects of drugs commonly used in the treatment of urinary tract infection." Med J Aust 1 (1972): 435-8
- "Product Information. Hiprex (methenamine)." Hoechst Marion Roussel (2002):
- "Product Information. Mandelamine (methenamine)." Parke-Davis (2002):
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
Gout
MajorMethenamine mandelate (salts), should be avoided in patients with gout as it may precipitate urate crystals in their urine. A similar situation may arise in patients with a predisposition to the formation of uric acid stones.
1 source
- "Product Information. Hiprex (methenamine)." Hoechst Marion Roussel (2002):
Liver Diseases
MajorThe use of methenamine and its salts (i.e. methenamine hippurate or mandelate) is contraindicated in patients with severe hepatic impairment. Methenamine is hydrolyzed to ammonia and formaldehyde in the urine under acidic conditions. Patients with liver disease may already have elevated ammonia levels, which can cause or exacerbate hepatic encephalopathy. Methenamine hippurate has also been associated with isolated cases of transient elevations in serum transaminases. The manufacturer recommends periodic liver function tests during therapy, particularly in patients with preexisting liver dysfunction.
5 sources
- Strom J, Jun H "Kinetics of hydrolysis of methenamine." Pharm Bull 23 (1975): 651
- Gleckman R, Alvarez S, Joubert D, Matthews S "Drug therapy reviews: methenamine mandelate and methenamine hippurate." Am J Hosp Pharm 36 (1979): 1509-12
- "Product Information. Hiprex (methenamine)." Hoechst Marion Roussel (2002):
- "Product Information. Mandelamine (methenamine)." Parke-Davis (2002):
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
Therapeutic duplication
Drug classes that overlap with Methenamine Hippurate, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
urinary anti-infectives
The recommended maximum number of medicines in the 'urinary anti-infectives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'urinary anti-infectives' category.
Example product in the source data (US market): Sulfamethoxazole/trimethoprim