Lenvatinib Mesylate interactions

Conditions

Conditions in which Lenvatinib Mesylate needs care, as documented in this source.

• Diarrhea

  Moderate

  Cases of diarrhea have been reported with the use of lenvatinib, sometimes leading to interruption of therapy. It is recommended to initiate prompt medical management for the development of diarrhea and to monitor for dehydration. It might be necessary to interrupt treatment with lenvatinib or resume at a reduced dose or permanently discontinue treatment with lenvatinib if severe or fatal diarrhea persists despite medical management. Care and close monitoring is recommended when using this agent in patients presenting diarrhea or at risk of developing diarrhea.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Heart Failure

  Moderate

  Cardiac dysfunctions, defined as decreased left or right ventricular function, cardiac failure, or pulmonary edema have been reported with the use of lenvatinib. It is recommended to monitor patients for clinical symptoms or signs of cardiac decompensation. Withhold lenvatinib therapy for development of Grade 3 cardiac dysfunction until improved and either resume at a reduced dose or discontinue its use depending on the severity and persistence of cardiac dysfunction. Discontinue lenvatinib for Grade 4 cardiac dysfunction.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Hemorrhage

  Moderate

  Hemorrhagic events, including fatal hemorrhagic events have been reported with the use of lenvatinib. It is recommended to withhold treatment and to either resume at a reduced dose or discontinue treatment depending on the severity and persistence of hemorrhage. Discontinue therapy in patients who experience severe or fatal hemorrhagic events. Prior to initiating treatment, consider the risk of severe or fatal hemorrhage associated with tumor invasion/infiltration of major blood vessels (e.g. carotid artery).

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Hepatic Insufficiency

  Moderate

  Hepatic failure, including fatal events have been reported with the use of lenvatinib. No dose adjustment is recommended in patients with mild or moderate hepatic impairment. Dose adjustment is needed in patients with severe hepatic impairment. It is recommended to monitor liver function before initiation of therapy with lenvatinib and regularly thereafter as clinically indicated. It might be necessary to temporarily withhold the use of lenvatinib and either resume at a reduced dose or discontinue treatment with lenvatinib depending on the severity and persistence of hepatic impairment. Discontinue treatment with lenvatinib for hepatic failure.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Hypertension

  Moderate

  The use of lenvatinib may cause hypertension. It is recommended to control blood pressure prior to treatment with lenvatinib and monitor blood pressure regularly during treatment as medically indicated. Withhold treatment with lenvatinib for Grade 3 hypertension despite optimal antihypertensive therapy. If clinically appropriate, resume at a reduced dose when hypertension is controlled and discontinue treatment for hypertension that becomes life-threatening. Care and close monitoring of blood pressure is recommended.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Hypocalcemia

  Moderate

  Cases of hypocalcemia have been reported with the use of lenvatinib. It is recommended to monitor blood calcium levels at least monthly and replace calcium as necessary during treatment and to interrupt and adjust dosing as necessary depending on severity, presence of ECG changes, and persistence of hypocalcemia. Care should be exercised when using this agent in patients at risk.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Hypothyroidism

  Moderate

  The use of lenvatinib impairs exogenous thyroid suppression and may cause hypothyroidism. It is recommended to monitor thyroid function before initiation of, and at least monthly throughout, treatment with lenvatinib. Care should be taken when using this agent in patients with thyroid dysfunction and treatment of hypothyroidism should be made according to standard medical practice to maintain a euthyroid state.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Kidney Diseases

  Moderate

  Cases of renal impairment have been reported with the use of lenvatinib. No dose adjustment is recommended in patients with mild or moderate renal impairment. Dose adjustment is needed in patients with severe renal impairment. It might be necessary to temporarily withhold the use of lenvatinib and either resume at a reduced dose or discontinue treatment with lenvatinib depending on the severity and persistence of renal impairment. Care and close monitoring is recommended when using lenvatinib in patients with end stage renal disease as these patients have not been studied.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Long QT Syndrome

  Moderate

  The use of lenvatinib may cause QT/QTc interval prolongation. It is recommended to monitor and correct electrolyte abnormalities in all patients and to monitor electrocardiograms in patients with congenital long QT syndrome, congestive heart failure, bradyarrhythmias, or those who are taking drugs known to prolong the QT interval, including Class Ia and III antiarrhythmics. Withhold treatment with lenvatinib for the development of QTc interval prolongation greater than 500 ms. and resume treatment at a reduced dose when QTc prolongation resolves to baseline.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Lung Diseases

  Moderate

  The use of certain multikinase inhibitors has been associated with pulmonary toxicity. Serious cases of interstitial lung disease (ILD), including fatal cases and interstitial pneumonitis or pulmonary fibrosis have been reported. Caution is recommended when using these agents in patients with a history of interstitial pneumonitis or pulmonary fibrosis or those patients presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation. If ILD is confirmed, permanently discontinue these agents and institute appropriate measures. Immediately withhold treatment in patients diagnosed with ILD/pneumonitis and permanently discontinue therapy if no other potential causes of ILD/pneumonitis have been identified.

  7 sources

  1. "Product Information. Vandetanib (vandetanib)." Astra-Zeneca Pharmaceuticals (2011):
  2. "Product Information. Zelboraf (vemurafenib)." Genentech (2011):
  3. "Product Information. Xalkori (crizotinib)." Pfizer U.S. Pharmaceuticals Group (2011):
  4. "Product Information. Mekinist (trametinib)." GlaxoSmithKline (2013):
  5. "Product Information. Zykadia (ceritinib)." Novartis Pharmaceuticals (2014):
  6. "Product Information. Zydelig (idelalisib)." Gilead Sciences (2014):
  7. "Product Information. Alecensa (alectinib)." Genentech (2015):

• Peptic Ulcer Perforation

  Moderate

  Cases of gastrointestinal perforation or fistula have been reported with the use of lenvatinib. Discontinue the use of lenvatinib in patients who develop gastrointestinal perforation or life-threatening fistula. Close monitoring should be exercised when using this agent in patients at risk.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Posterior Leukoencephalopathy Syndrome

  Moderate

  The use of lenvatinib may cause reversible posterior leukoencephalopathy syndrome (RPLS). Consider this syndrome in any patient presenting with seizures, headache, visual disturbances, confusion or altered mental function. Confirm the diagnosis of RPLS with MRI and if positive, withhold therapy for RPLS until fully resolved. Upon resolution, resume at a reduced dose or discontinue treatment depending on the severity and persistence of neurologic symptoms and administer appropriate treatment as clinically indicated.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Proteinuria

  Moderate

  Proteinuria has been reported with the use of lenvatinib. It is recommended to monitor for proteinuria before initiation of, and periodically throughout treatment. Withhold lenvatinib for >=2 grams of proteinuria/24 hours and resume at a reduced dose when proteinuria is <2 gm/24 hours. Discontinue lenvatinib for nephrotic syndrome.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):

• Thromboembolism

  Moderate

  In clinical trials, arterial thromboembolic events were reported in patients treated with lenvatinib. It is recommended to discontinue lenvatinib following an arterial thrombotic event. Care should be exercised when resuming lenvatinib after an arterial thromboembolic event as its safety has not been established and its use has not been studied in patients who have had an arterial thromboembolic event within the previous 6 months.

  1 source

  1. "Product Information. Lenvima (lenvatinib)." Eisai Inc (2015):