Pentoxifylline interactions
Full monograph for PentoxifyllineCheck it against another medicine
Medicines
392 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Acalabrutinib | Major | Synergy | Coadministration of acalabrutinib and drugs that interfere with platelet function or coagulation may potentiate the risk of bleeding complications. | 3 sources — open the full entry |
| Ketorolac Tromethamine | Major | Synergy | The concomitant use of pentoxifylline and ketorolac may increase the risk of bleeding. Bleeding events have been reported in postoperative patients who were… | 1 sources — open the full entry |
| Abametapir | Moderate | Metabolism | Based on in vitro inhibition data, a single topical application of abametapir lotion may increase plasma concentrations of drugs that are substrates of CYP450… | 1 sources — open the full entry |
| Alfuzosin Hydrochloride | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Allium cepa + Heparin + Allantoin | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| Alteplase | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| Ambrisentan | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Aminophylline | Moderate | Metabolism | Coadministration with pentoxifylline may increase the serum concentrations of theophylline. The mechanism of interaction has not been described, but may… | 4 sources — open the full entry |
| Amlodipine Besilate | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Amlodipine Besilate + Atenolol | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Amlodipine Besilate + Atorvastatin | Moderate | Synergy · Unknown | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Amlodipine Besilate + Benazepril Hydrochloride | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Amlodipine Besilate + Olmesartan Medoxomil | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Amlodipine Besilate + Telmisartan | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Amlodipine Besilate + Valsartan | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Apixaban | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| Aspirin | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| Aspirin + Dipyridamole | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by…2 documented mechanisms | 2 sources — open the full entry |
| Atenolol | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Atenolol + Chlorthalidone | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Avanafil | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Azilsartan Medoxomil | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 2 sources — open the full entry |
| Azilsartan Medoxomil + Chlorthalidone | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…3 documented mechanisms | 2 sources — open the full entry |
| Betaxolol Hydrochloride | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Betrixaban | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| Bimatoprost + Timolol | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Biphasic Insulin Aspart | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines… | 86 sources — open the full entry |
| Bisoprolol Fumarate | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Bisoprolol Fumarate + Amlodipine Besilate | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Bisoprolol Fumarate + Hydrochlorothiazide | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Bivalirudin | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| Bosentan Monohydrate | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Brimonidine Tartrate + Timolol Maleate | Moderate | Synergy · Unknown | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with…2 documented mechanisms | 1 sources — open the full entry |
| Brinzolamide + Timolol | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Bromfenac Sodium | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| Bumetanide | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Candesartan Cilexetil | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. | 1 sources — open the full entry |
| Candesartan Cilexetil + Hydrochlorothiazide | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents.2 documented mechanisms | 2 sources — open the full entry |
| Capmatinib Hydrochloride | Moderate | Metabolism | Coadministration with inhibitors of CYP450 1A2 may increase the plasma concentrations of pentoxifylline and its active hydroxy metabolite (M1), both of which… | 2 sources — open the full entry |
| Captopril | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Carvedilol | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Chlorthalidone | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Cilostazol | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| CiprofloxacinbaseOphthalmic | Moderate | Metabolism | Coadministration with inhibitors of CYP450 1A2 may increase the plasma concentrations of pentoxifylline and its active hydroxy metabolite (M1), both of which… | 2 sources — open the full entry |
| Ciprofloxacin + Dexamethasone | Moderate | Metabolism · Unknown | Coadministration with inhibitors of CYP450 1A2 may increase the plasma concentrations of pentoxifylline and its active hydroxy metabolite (M1), both of which…2 documented mechanisms | 2 sources — open the full entry |
| Ciprofloxacin + Hydrocortisone Acetate | Moderate | Metabolism | Coadministration with inhibitors of CYP450 1A2 may increase the plasma concentrations of pentoxifylline and its active hydroxy metabolite (M1), both of which… | 2 sources — open the full entry |
| Clonidine Hydrochloride | Moderate | Synergy | Pentoxifylline may potentiate the action of hypotensive agents. Small decreases in blood pressure have been observed in some patients treated with… | 1 sources — open the full entry |
| Clopidogrel + Aspirin | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by…2 documented mechanisms | 2 sources — open the full entry |
| Clopidogrel Bisulphate | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
| Dabigatran Etexilate Mesylate | Moderate | Synergy | The use of pentoxifylline has been associated with bleeding and/or prolongation in prothrombin time. Theoretically, the risk of bleeding may be increased by… | 2 sources — open the full entry |
Conditions
Conditions in which Pentoxifylline needs care, as documented in this source.
Cerebral Hemorrhage
MajorThe use of pentoxifylline is contraindicated in patients with recent cerebral and/or retinal hemorrhage. Dose-related hemorrhagic effects can occur.
1 source
- "Product Information. Trental (pentoxifylline)." Hoechst Marion Roussel (2001):
Cardiomyopathies
ModerateAlthough pentoxifylline has been used safely to treat peripheral arterial disease in patients with concurrent coronary artery and cerebrovascular diseases, there have been occasional reports of angina, arrhythmia, and hypotension. Controlled trials do not show a causal relationship; however, since pentoxifylline is a methylxanthine derivative, the possibility of these adverse effects should be considered. Therapy with pentoxifylline should be administered cautiously in patients with arrhythmia, coronary artery and/or cerebrovascular insufficiency.
1 source
- "Product Information. Trental (pentoxifylline)." Hoechst Marion Roussel (2001):
Hepatic Insufficiency
ModerateIn patients with hepatic or renal impairment, the exposure to pentoxifylline and/or active metabolites is increased. The consequences of the increase in drug exposure are not known. Caution is advised. Care should be taken in dose selection, and it may be useful to monitor renal and hepatic function.
1 source
- "Product Information. Trental (pentoxifylline)." Hoechst Marion Roussel (2001):