Pyridoxine Hydrochloride interactions
Checked as Pyridoxine in this data source.
Full monograph for Pyridoxine HydrochlorideCheck it against another medicine
Medicines
8 documented
Mechanism
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Carbidopa + LevodopaExtended releaseProlonged release | Moderate | Antagonism | Pyridoxine doses of 5 mg/day or more antagonise the effects of levodopa. In the presence of pyridoxine, the peripheral metabolism of levodopa to dopamine is… | 14 sources — open the full entry |
| Levodopa + Benserazide | Moderate | Antagonism | Pyridoxine doses of 5 mg/day or more antagonise the effects of levodopa. In the presence of pyridoxine, the peripheral metabolism of levodopa to dopamine is… | 14 sources — open the full entry |
| Levodopa + Carbidopa | Moderate | Antagonism | Pyridoxine doses of 5 mg/day or more antagonise the effects of levodopa. In the presence of pyridoxine, the peripheral metabolism of levodopa to dopamine is… | 14 sources — open the full entry |
| Levodopa + Carbidopa + Entacapone | Moderate | Antagonism | Pyridoxine doses of 5 mg/day or more antagonise the effects of levodopa. In the presence of pyridoxine, the peripheral metabolism of levodopa to dopamine is… | 14 sources — open the full entry |
| Phenobarbital | Moderate | Others | Large doses of pyridoxine (greater than 200 mg/day) may decrease the concentration of certain antiepileptic medications, including phenytoin and phenobarbital… | 57 sources — open the full entry |
| Phenytoin Sodium | Moderate | Others | Large doses of pyridoxine (greater than 200 mg/day) may decrease the concentration of certain antiepileptic medications, including phenytoin and phenobarbital… | 57 sources — open the full entry |
| Primidone | Minor | Others | One small study has suggested that pyridoxine may decrease serum levels of phenobarbital. The mechanism is unknown. Phenobarbital is the only barbiturate… | 1 sources — open the full entry |
| Thiopental Sodium | Minor | Others | One small study has suggested that pyridoxine may decrease serum levels of phenobarbital. The mechanism is unknown. Phenobarbital is the only barbiturate… | 1 sources — open the full entry |
Conditions
Conditions in which Pyridoxine Hydrochloride needs care, as documented in this source.
Malabsorption Syndromes
ModerateThe B vitamins are readily absorbed in the GI tract following oral administration. However, GI absorption may be decreased in patients with malabsorption syndromes and other conditions. For example, the absorption of thiamine and pyridoxine may commonly be decreased in alcoholics and in patients with cirrhosis. Likewise, riboflavin absorption may be impaired in patients with hepatitis, cirrhosis, or biliary obstruction. When malabsorption of these vitamins is suspected, parenteral administration may be appropriate.
3 sources
- "Product Information. Vitelle Nestrex (pyridoxine)." Fielding Company
- "Product Information. Vitamin B1 (thiamine)." Dixon-Shane Inc (2001):
- "Product Information. Quinine (riboflavin)." Watson/Rugby Laboratories Inc, Norcross, GA.