Recombinant Follicle Stimulating Hormone (rFSH) interactions

Conditions

Conditions in which Recombinant Follicle Stimulating Hormone (rFSH) needs care, as documented in this source.

• Adrenal Insufficiency

  Major

  The use of follicle stimulating hormone (FSH) is contraindicated in patients with uncontrolled adrenal dysfunction. Uncontrolled adrenal dysfunction may involve the pituitary gland and be associated with a tumor or other dysfunction. Administration of FSH may exacerbate the condition.

  4 sources

  1. "Product Information. Fertinex (urofollitropin)." Serono Laboratories Inc
  2. "Product Information. Follistim (follicle stimulating hormone)." Organon (2002):
  3. "Product Information. Gonal-F (follicle stimulating hormone)." Serono Laboratories Inc (2002):
  4. "Product Information. Bravelle (urofollitropin)." Ferring Pharmaceuticals Inc (2003):

• Hypothyroidism

  Major

  The use of follicle stimulating hormone (FSH) is contraindicated in patients with uncontrolled thyroid dysfunction. FSH is composed of both an alpha and beta subunit. The amino acid sequence of the alpha subunit of FSH is identical to that of TSH. Therefore, FSH may have weak TSH receptor- binding and activation.

  4 sources

  1. "Product Information. Fertinex (urofollitropin)." Serono Laboratories Inc
  2. "Product Information. Follistim (follicle stimulating hormone)." Organon (2002):
  3. "Product Information. Gonal-F (follicle stimulating hormone)." Serono Laboratories Inc (2002):
  4. "Product Information. Bravelle (urofollitropin)." Ferring Pharmaceuticals Inc (2003):

• Neoplasms

  Major

  The use of follicle stimulating hormone is contraindicated in patients with sex hormone-dependent tumors of the reproductive tract and accessory organs (ovary, breast, uterus) and in patients with pituitary tumors. FSH is required for normal sex hormone production, which may be detrimental in these patients. Patients in later reproductive life have a greater predisposition to endometrial carcinoma.

  4 sources

  1. "Product Information. Fertinex (urofollitropin)." Serono Laboratories Inc
  2. "Product Information. Follistim (follicle stimulating hormone)." Organon (2002):
  3. "Product Information. Gonal-F (follicle stimulating hormone)." Serono Laboratories Inc (2002):
  4. "Product Information. Bravelle (urofollitropin)." Ferring Pharmaceuticals Inc (2003):