Testosterone interactions

Conditions

Conditions in which Testosterone needs care, as documented in this source.

• Blood Coagulation Disorders

  Major

  Androgenic anabolic steroids may cause suppression of clotting factors II, V, VII, and X, and an increase in prothrombin time. Androgen therapy should be administered cautiously in patients with bleeding disorders.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Breast Neoplasms

  Major

  When treated with androgenic anabolic steroids, patients with metastatic breast cancer may develop hypercalcemia due to osteolysis. Frequent determination of urine and serum calcium levels is recommended during therapy with androgenic agents. If hypercalcemia occurs, therapy should be stopped. The development of hypercalcemia may indicate progression of metastases to the bone.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Hyperlipoproteinemias

  Major

  Androgenic anabolic steroids may adversely affect serum lipids, including lowering HDL and elevating LDL levels. These changes can be marked, particularly with the 17-alpha-alkyl derivatives (i.e., fluoxymesterone, methyltestosterone, oxandrolone, oxymetholone, and stanozolol), and may significantly impact the risk of atherosclerosis and coronary artery disease. Patients with preexisting hyperlipoproteinemia may require closer monitoring during therapy with androgenic agents, and adjustments made accordingly in their lipid-lowering regimen. Androgen therapy should be administered cautiously in patients with coronary artery disease or a history of ischemic heart disease.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Liver Diseases

  Major

  The use of androgenic anabolic steroids may be associated with development of cholestatic hepatitis and jaundice. Other, more serious hepatotoxicities such as peliosis hepatis and hepatocellular neoplasms are rare but may occur with prolonged use or high dosages. These latter toxicities may be fatal and often not recognized until they become life-threatening. Patients with preexisting liver diseases should be monitored more closely during therapy with anabolic steroids if they are used. If liver function declines or toxicity occurs, therapy should be withdrawn and the cause investigated.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Liver Diseases

  Major

  The use of testosterone is contraindicated in patients with serious hepatic or renal disease.

  1 source

  1. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Polycythemia

  Major

  Androgenic anabolic steroids may cause polycythemia when given in high dosages or for prolonged periods. Patients with preexisting polycythemia may experience worsening of their condition. Frequent monitoring of clinical status and hemoglobin and hematocrit levels is recommended if androgen therapy is administered to these patients.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Prostatic Neoplasms

  Major

  The use of androgenic anabolic steroids is contraindicated for male patients with carcinoma of the breast or prostate. Circulating androgens can be converted in peripheral tissues to estrogens and dihydrotestosterone, which may act as promoters of tumor growth in the breast and prostate, respectively. Likewise, androgenic agents may cause enlargement of the prostate and should be used cautiously in patients with or predisposed to prostatic hypertrophy.

  3 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):
  3. Braunwald E, Hauser SL, Kasper DL, Fauci AS, Isselbacher KJ, Longo DL, Martin JB, eds., Wilson JD "Harrison's Principles of Internal Medicine." New York, NY: McGraw-Hill Health Professionals Division (1998):

• Water-Electrolyte Imbalance

  Major

  Androgenic anabolic steroids may cause sodium and water retention, particularly when given in high dosages or for prolonged periods. Therapy with these agents should be administered cautiously in patients who have preexisting problems with fluid overload or are at risk for developing edema. The manufacturers consider the use of androgenic agents to be contraindicated in patients with severe cardiac, renal and/or hepatic dysfunction.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Diabetes Mellitus

  Moderate

  The metabolic effects of androgenic anabolic steroids may lower blood glucose. Decreased glucose tolerance and increased insulin resistance have also been reported. Patients with diabetes mellitus should be monitored more closely during therapy with androgenic agents, and their antidiabetic regimen adjusted accordingly.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Hypercalcemia

  Moderate

  Androgenic anabolic steroids decrease urinary excretion of calcium, which may result in hypercalcemia. Therapy with androgenic agents should be administered cautiously in patients with hypercalcemia, disorders of bone metabolism such as hyperparathyroidism, or renal dysfunction. Some manufacturers consider the use of androgenic anabolic steroids to be contraindicated in patients with hypercalcemia.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):

• Thyroid Diseases

  Minor

  When androgenic anabolic steroids are used in patients with thyroid disorders, clinicians should be aware that these agents may affect thyroid function tests. Specifically, thyroid-binding globulin levels may be decreased, resulting in lower total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however.

  2 sources

  1. "Product Information. Halotestin (fluoxymesterone)." Pharmacia and Upjohn (2001):
  2. "Product Information. Androderm (testosterone topical)." SmithKline Beecham (2001):