Vasopressin interactions

Food & lifestyle

• alcohol

  Moderate

  Antagonism

  Alcohol may decrease the antidiuretic effect of vasopressin.

  What to do: Patients should be advised to abstain from alcohol during vasopressin treatment. Hemodynamic monitoring is suggested for patients known to drink alcohol while receiving vasopressin.

  7 sources

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. "Product Information. Vasostrict (vasopressin)." Par Pharmaceutical Inc (2017):
  4. Taivainen H, Laitinen K, Tahtela R, Kilanmaa K, Valimaki MJ "Role of plasma vasopressin in changes of water balance accompanying acute alcohol intoxication." Alcohol Clin Exp Res 19 (1995): 759-62
  5. Collins GB, Brosnihan KB, Zuti RA, Messina M, Gupta MK "Neuroendocrine, fluid balance, and thirst responses to alcohol in alcoholics." Alcohol Clin Exp Res 16 (1992): 228-32
  6. Hirschl MM, Derfler K, Bieglmayer C, et al. "Hormonal derangements in patients with severe alcohol intoxication." Alcohol Clin Exp Res 18 (1994): 761-6
  7. Harper KM, Knapp DJ, Criswell HE, Breese GR "Vasopressin and alcohol: A multifaceted relationship." Psychopharmacology (Berl) 235 (2018): 3363-79

Conditions

Conditions in which Vasopressin needs care, as documented in this source.

• Kidney Diseases

  Major

  Vasopressin is contraindicated in patients with chronic nephritis with nitrogen retention. This until reasonable nitrogen blood levels have been attained.

  1 source

  1. "Product Information. Pitressin (vasopressin)." Parke-Davis (2001):

• Nephritis

  Major

  Chronic nephritis with nitrogen retention contraindicates the use of vasopressin until reasonable nitrogen blood levels have been attained.

  1 source

  1. "Product Information. Pitressin (vasopressin)." Parke-Davis (2001):

• Vascular Diseases

  Major

  Vasopressin should not be used in patients with vascular disease, especially disease of the coronary arteries, except with extreme caution. In such patients, even small doses may precipitate anginal pain, and large doses may cause myocardial infarction. If a decision is made to use the drug, ECG monitoring should be performed periodically during therapy.

  11 sources

  1. Beller BM, Trevino A, Urban E "Pitressin-induced myocardial injury and depression in a young woman." Am J Med 51 (1971): 675-9
  2. Kelly KJ, Stang JM, Mekhjian HS "Vasopressin provocation of ventricular dysrhythmia." Ann Intern Med 92 (1980): 205-6
  3. Colombani P "Upper extremity gangrene secondary to superior mesenteric artery infusion of vasopressin." Dig Dis Sci 27 (1982): 367-9
  4. Greenwald RA, Rheingold OJ, Chiprut RO, Rogers AI "Local gangrene: a complication of peripheral Pitressin therapy for bleeding esophageal varices." Gastroenterology 74 (1978): 744-6
  5. Lambert M, de Peyer R, Muller AF "Reversible ischemic colitis after intravenous vasopressin therapy." JAMA 247 (1982): 666-7
  6. Khokhar AM, Slater JD, Ma J, Ramage CM "The cardiovascular effect of vasopressin in relation to its plasma concentration in man and its relevance to high blood pressure." Clin Endocrinol (Oxf) 13 (1980): 259-66
  7. Wormser GP, Kornblee LV, Gottfried EB "Cutaneous necrosis following peripheral intravenous vasopressin therapy." Cutis 29 (1982): 249-52
  8. Jacoby AG, Wiegman MV "Cardiovascular complications of intravenous vasopressin therapy." Focus Crit Care 17 (1990): 63-6

  Show all 11 sourcesShow fewer sources

  9. Brearley S, Hawker PC, Dykes PW, Keighley MR "A lethal complication of peripheral vein vasopressin infusion." Hepatogastroenterology 32 (1985): 224-5
  10. Butow KW, de Witt TW, Jacobs FJ "Ornithine-vasopressin gangrene and reconstruction of the upper lip. Case report." J Craniomaxillofac Surg 17 (1989): 88-91
  11. "Product Information. Pitressin (vasopressin)." Parke-Davis (2001):

• Water Intoxication

  Major

  Water intoxication and hyponatremia may occur during therapy with vasopressin or desmopressin due to their antidiuretic action. Patients are most likely to experience this problem if their fluid intake is excessive or if they do not require antidiuresis, such as when they are administered these agents for their hemostatic effects. Fluid intake should be adjusted carefully to avoid overhydration, particularly in children, elderly, and patients with conditions that may be exacerbated by fluid retention, including epilepsy, migraine, asthma, and heart failure. Patients should be monitored for signs of water intoxication (e.g., listlessness, drowsiness, and headaches), which may rarely progress to seizures and coma. The use of desmopressin is contraindicated in patients with hyponatremia or a history of hyponatremia.

  8 sources

  1. "Product Information. Pitressin (vasopressin)." Parke-Davis (2001):
  2. "Product Information. DDAVP (desmopressin)." Rhone Poulenc Rorer (2001):
  3. "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals (2001):
  4. Lin TW, Kuo YS "Acute pulmonary oedema following administration of vasopressin for control of massive GI tract haemorrhage in a major burn patient." Burns 22 (1996): 73-5
  5. Tulandi T, Beique F, Kimia M "Pulmonary edema: a complication of local injection of vasopressin at laparoscopy." Fertil Steril 66 (1996): 478-80
  6. Robson WLM "Water intoxication in patients treated with desmopressin." Pharmacotherapy 16 (1996): 969-70
  7. Williford SL "Water intoxication in patients treated with desmopressin - reply." Pharmacotherapy 16 (1996): 970
  8. Robson WLM, Norgaard JP, Leung AKC "Hyponatremia in patients with nocturnal enuresis treated with DDAVP." Eur J Pediatr 155 (1996): 959-62