Vitamin C [Ascorbic acid] interactions
Checked as Ascorbic acid in this data source.
Full monograph for Vitamin C [Ascorbic acid]Check it against another medicine
Medicines
28 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Aluminium Hydroxide + Magnesium Hydroxide | Moderate | Absorption · Excretion | In patients with advanced renal impairment or on dialysis, chronic use of aluminum-containing preparations while taking high doses of ascorbic acid may result… | 3 sources — open the full entry |
| Aluminium Hydroxide + Magnesium Hydroxide + Simethicone | Moderate | Absorption · Excretion | In patients with advanced renal impairment or on dialysis, chronic use of aluminum-containing preparations while taking high doses of ascorbic acid may result… | 3 sources — open the full entry |
| Bortezomib | Moderate | Antagonism | Preliminary data suggest that ascorbic acid may diminish the antitumor effects of bortezomib when taken simultaneously. In vitro, ascorbic acid has been shown… | 3 sources — open the full entry |
| Deferoxamine Mesylate | Moderate | Others | Although ascorbic acid is commonly given during deferoxamine treatment, cardiac disorders (left ventricular dysfunction) and cataracts have been reported with… | 2 sources — open the full entry |
| Sucralfate | Moderate | Absorption · Excretion | In patients with advanced renal impairment or on dialysis, chronic use of aluminum-containing preparations while taking high doses of ascorbic acid may result… | 3 sources — open the full entry |
| Cisplatin | Minor | Synergy | One study found that ascorbic acid can improve the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro… | 11 sources — open the full entry |
| Cyproterone Acetate + Ethinyl Estradiol | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 38 sources — open the full entry |
| Dextromethorphan + Pseudoephedrine + Triprolidine | Minor | Excretion | Acidic urine increases the elimination of ephedrine and pseudoephedrine and decreases the elimination half-life. The clinical significance is unknown. The… | 3 sources — open the full entry |
| Doxorubicin Hydrochloride | Minor | Synergy | One study found that ascorbic acid can improve the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro… | 11 sources — open the full entry |
| Doxorubicin Hydrochloride Liposome | Minor | Synergy | One study found that ascorbic acid can improve the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro… | 11 sources — open the full entry |
| Drospirenone + Estetrol | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 4 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol0.02 mg0.03 mg | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol + Levomefolate | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 38 sources — open the full entry |
| Ephedrine Hydrochloride | Minor | Excretion | Acidic urine increases the elimination of ephedrine and pseudoephedrine and decreases the elimination half-life. The clinical significance is unknown. The… | 3 sources — open the full entry |
| Ethinyl Estradiol + Desogestrel0.02 mg0.03 mg | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 38 sources — open the full entry |
| Ethinyl Estradiol + Gestodene | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 38 sources — open the full entry |
| Ethinyl Estradiol + Levonorgestrel + Ferrous Fumarate | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 38 sources — open the full entry |
| Ethinyl Estradiol + Lynestrenol0.0375 mg0.05 mg | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 38 sources — open the full entry |
| Flecainide Acetate | Minor | Excretion | Agents that acidify the urine enhance the renal elimination of flecainide. The result may be decreased plasma flecainide levels and decreased effectiveness… | 1 sources — open the full entry |
| Fluphenazine + Nortriptyline | Minor | Others | case report suggests that ascorbic acid may reduce the therapeutic effect of fluphenazine. | 1 sources — open the full entry |
| Fluphenazine Decanoate | Minor | Others | case report suggests that ascorbic acid may reduce the therapeutic effect of fluphenazine. | 1 sources — open the full entry |
| Loratadine + Pseudoephedrine | Minor | Excretion | Acidic urine increases the elimination of ephedrine and pseudoephedrine and decreases the elimination half-life. The clinical significance is unknown. The… | 3 sources — open the full entry |
| Nab-Paclitaxel [Nanoparticle Albumin-Bound Paclitaxel] | Minor | Synergy | One study found that ascorbic acid can improve the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro… | 11 sources — open the full entry |
| Norgestrel + Ethinyl Estradiol + Ferrous Fumarate | Minor | Metabolism | Ascorbic acid may increase the serum levels of estrogens in oral contraceptives. The mechanism may be due to decreased metabolism of the estrogen by… | 38 sources — open the full entry |
| Paclitaxel | Minor | Synergy | One study found that ascorbic acid can improve the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro… | 11 sources — open the full entry |
| Propranolol Hydrochloride | Minor | Absorption | Limited data suggest that ascorbic acid may decrease the oral bioavailability of propranolol by possibly interfering with its absorption from the… | 3 sources — open the full entry |
| Pseudoephedrine + Guaiphenasine + Triprolidine | Minor | Excretion | Acidic urine increases the elimination of ephedrine and pseudoephedrine and decreases the elimination half-life. The clinical significance is unknown. The… | 3 sources — open the full entry |
| Warfarin Sodium | Minor | Others | The use of ascorbic acid has been implicated in causing warfarin resistance. However, controlled clinical trials have not demonstrated clinically important… | 42 sources — open the full entry |
Conditions
Conditions in which Vitamin C [Ascorbic acid] needs care, as documented in this source.
Heart Failure
ModerateAscorbic acid preparations contain sodium. The sodium content should be considered when used in patients with sodium restricted diets and conditions require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
1 source
- "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical
Hemolysis
ModerateAcute hemolysis following administration of high doses of ascorbic acid in patients with glucose-6-phosphate deficiency (G6PD) has been reported. Ascorbic acid should be administered cautiously and dosages modified in patients with G6PD.
1 source
- "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical
Kidney Calculi
ModerateLarge doses of ascorbic acid have lead to hyperoxaluria in 5% of patients. Ascorbic acid can acidify urine resulting in precipitation of urate, cystine, or oxalate stones. Ascorbic acid should be administered cautiously and dosages modified in patients predisposed to renal stones. Clinical monitoring of urinalysis for pH and crystal formation is recommended.
1 source
- "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical
Diseases requiring dialysis
MinorAscorbic acid is removed by dialysis.
1 source
- "Product Information. Cemill 500 (ascorbic acid)." Abbott Pharmaceutical