Dipyridamole interactions

Food & lifestyle

• coffee

  Moderate

  Antagonism

  Caffeine and other xanthine derivatives (e.g., theophylline) are nonspecific, competitive antagonists of adenosine receptors. As such, they may interfere with the vasodilating effect of dipyridamole, an adenosine receptor agonist.

  What to do: Patients should avoid consumption of caffeine-containing products for at least 24 hours prior to administration of dipyridamole for myocardial perfusion imaging.

  3 sources

  1. Smits P, Aengevaeren WR, Corstens FH, Thien T "Caffeine reduces dipyridamole-induced myocardial ischemia." J Nucl Med 30 (1989): 1723-6
  2. "Product Information. Persantine (dipyridamole)." Boehringer-Ingelheim (2002):
  3. Ranhosky A, Kempthorne-Rawson J, the Intravenous Dipyridamole Thallium Imaging Study Group "The safety of intravenous dipyridamole thallium myocardial perfusion imaging." Circulation 81 (1990): 1205-9

Conditions

Conditions in which Dipyridamole needs care, as documented in this source.

• Bronchial Spasm

  Major

  Dipyridamole is a phosphodiesterase inhibitor and can exacerbate bronchospasm, particularly in patients with reactive airway disease and/or chronic obstructive pulmonary disease (COPD). Therapy with dipyridamole is contraindicated in patients with active wheezing and should be administered cautiously in patients with asthma or COPD.

  3 sources

  1. Lette J, Cerino M, Laverdiere M, Tremblay J, Prenovault J "Severe bronchospasm followed by respiratory arrest during thallium- dipyridamole imaging." Chest 95 (1989): 1345-7
  2. Eagle KA, Boucher CA "Intravenous dipyridamole infusion causes severe bronchospasm in asthmatic patients." Chest 95 (1989): 258-9
  3. "Product Information. Persantine (dipyridamole)." Boehringer-Ingelheim (2002):

• Hypotension

  Moderate

  Dipyridamole can cause peripheral vasodilation. Therapy with dipyridamole should be administered cautiously in patients with hypotension.

  5 sources

  1. Castello R, Hidalgo R "Dipyridamole-induced myocardial ischemia ." JAMA 259 (1988): 1179
  2. "Product Information. Persantine (dipyridamole)." Boehringer-Ingelheim (2002):
  3. Roach PJ, Magee MA, Freedman SB "Asystole and bradycardia during dipyridamole stress testing in patients receiving beta blockers." Int J Cardiol 42 (1993): 92-4
  4. Mauro RL, Sabella FP, Enia F "Sinus arrest associated with dipyridamole infusion." Chest 105 (1994): 604-5
  5. Lo Mauro R, Sabella FP, Enia F "Sinus arrest associated with dipyridamole infusion." Chest 106 (1994): 984

• Long QT Syndrome

  Moderate

  Serious adverse reactions associated with the administration of intravenous dipyridamole have included cardiac death, fatal and non- fatal myocardial infarction, ventricular fibrillation, symptomatic ventricular tachycardia, stroke, transient cerebral ischemia, seizures, anaphylactoid reaction and bronchospasm. There have been reported cases of asystole, sinus node arrest, sinus node depression and conduction block. Patients with abnormalities of cardiac impulse formation/conduction or severe coronary artery disease may be at increased risk for these events. Caution is recommended.

  1 source

  1. "Product Information. Persantine (dipyridamole)." Boehringer-Ingelheim (2002):

• Myasthenia Gravis

  Moderate

  Myasthenia gravis patients receiving therapy with cholinesterase inhibitors may experience worsening of their disease in the presence of dipyridamole. Caution should be exercised with these patients.

  1 source

  1. "Product Information. Persantine (dipyridamole)." Boehringer-Ingelheim (2002):