Folic Acid interactions
Full monograph for Folic AcidCheck it against another medicine
Medicines
514 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Capecitabine | Major | Synergy | Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU). The exact mechanism of interaction is unknown. Although… | 9 sources — open the full entry |
| Fluorouracil | Major | Synergy | Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU). The exact mechanism of interaction is unknown. Although… | 9 sources — open the full entry |
| Carbamazepine | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Ethosuximide | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Fosphenytoin Sodium | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Lamotrigine | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Methotrexate | Moderate | Antagonism | Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic… | 4 sources — open the full entry |
| Oxcarbazepine | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Phenobarbital | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Phenytoin Sodium | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Primidone | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Sodium Valproate | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Sulphadoxine + Pyrimethamine | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Sulphamethoxazole + Trimethoprim | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Triamterene + Hydrochlorothiazide | Moderate | Antagonism · Unknown | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Sulfasalazine | Minor | Absorption · Metabolism | Sulfasalazine may impair the intestinal absorption and/or metabolism of folic acid to its physiologically useful form. Folate deficiency, sometimes manifested… | 15 sources — open the full entry |
Food & lifestyle
alcohol
ModerateSynergy
Ethanol may increase folic acid elimination and folic acid absorption is decreased in chronic alcoholics. Excessive alcohol consumption may lead to folate deficiency.
What to do: Monitoring of patient response to folic acid supplementation if they also consume alcohol regularly may be recommended.
5 sources
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia Espa?ola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaci��n online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
- Cerner Multum, Inc "ANVISA Bul��rio Eletr?nico." O 0 (2015):
- "Product Information. Folic Acid (folic acid)." Method Pharmaceuticals, LLC (2017):
Conditions
Conditions in which Folic Acid needs care, as documented in this source.
Anemia
MajorThe use of folic acid is contraindicated in patients with undiagnosed anemia. Folic acid in dosages above 1 mg/day can obscure the diagnosis of pernicious anemia by alleviating the hematologic abnormalities while allowing the progression of neurologic complications. In addition, folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.
3 sources
- Butterworth CE Jr, Tamura T "Folic acid safety and toxicity: a brief review." Am J Clin Nutr 50 (1989): 353-8
- Katz M "Potential danger of self-medication with folic acid." N Engl J Med 289 (1973): 1095
- "Product Information. Renal Multivitamin Formula Rx (folic acid)." Vitaline Corporation, Ashland, OR.