Sulphadoxine + Pyrimethamine interactions
Checked as Sulfadoxine + Pyrimethamine in this data source.
Full monograph for Sulphadoxine + PyrimethamineCheck it against another medicine
Medicines
111 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Cyclosporine (Oral)via Sulfadoxinematched approximately | Major | Others | Sulfonamides may significantly reduce serum cyclosporine concentrations by an unknown mechanism. Allograft rejections have resulted. Hyperkalemia and additive… | 22 sources — open the full entry |
| Deferipronevia Pyrimethamine | Major | Synergy | Coadministration of deferiprone and other drugs that can cause neutropenia or agranulocytosis may increase the risk and/or severity of hematologic toxicity… | 5 sources — open the full entry |
| Ketoconazolevia Sulfadoxinematched approximately | Major | Synergy | Use of hepatotoxic drugs together with ketoconazole or levoketoconazole may potentiate the risk of liver injury. | 3 sources — open the full entry |
| Ketoconazole + Zinc Pyrithione + Aleoveravia Sulfadoxinematched approximately | Major | Synergy | Use of hepatotoxic drugs together with ketoconazole or levoketoconazole may potentiate the risk of liver injury. | 3 sources — open the full entry |
| Lidocaine + Prilocainevia Sulfadoxinematched approximately | Major | Synergy | Prilocaine can cause dose-related methemoglobin formation via its ortho-toluidine metabolite. Coadministration with other oxidizing agents that can also induce…2 documented mechanisms | 13 sources — open the full entry |
| Methenamine Hippuratevia Sulfadoxinematched approximately | Major | Others | Some sulfonamides can form an insoluble precipitate with formaldehyde, which is generated from the hydrolysis of methenamine in acidic urine maintained by the… | 2 sources — open the full entry |
| Warfarin Sodiumvia Sulfadoxine, Pyrimethaminematched approximately | Major | Distribution · Metabolism · Unknown | Coadministration with a sulfonamide may increase the plasma concentrations and hypoprothrombinemic effects of coumarin anticoagulants. The proposed mechanism…2 documented mechanisms | 58 sources — open the full entry |
| Aluminium Hydroxide + Magnesium Hydroxidevia Pyrimethamine | Moderate | Absorption | INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its…2 documented mechanisms | 2 sources — open the full entry |
| Aluminium Hydroxide + Magnesium Hydroxide + Simethiconevia Pyrimethamine | Moderate | Absorption | INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its…2 documented mechanisms | 2 sources — open the full entry |
| Aluminium Oxide + Magnesium Trisilicatevia Pyrimethamine | Moderate | Absorption | The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its absorption. | 2 sources — open the full entry |
| Artemether + Lumefantrinevia Pyrimethamine | Moderate | Others | There are limited data on the safety and efficacy of artemether-lumefantrine in combination with other antimalarial agents. | 4 sources — open the full entry |
| Benzocaine + Butamben + Tetracaine Hydrochloridevia Sulfadoxinematched approximately | Moderate | Antagonism | Ester-type local anesthetics are hydrolyzed to paraaminobenzoic acid, which can inhibit the action of sulfonamides.2 documented mechanisms | 2 sources — open the full entry |
| Biphasic Insulin Aspartvia Sulfadoxinematched approximately | Moderate | Synergy | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines… | 76 sources — open the full entry |
| Calcium Carbonatevia Pyrimethamine | Moderate | Absorption | INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its… | 2 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin Cvia Pyrimethamine | Moderate | Absorption | INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its… | 2 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C + Vitamin D3via Pyrimethamine | Moderate | Absorption | INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its… | 2 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3via Pyrimethamine | Moderate | Absorption | INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its… | 2 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3 + Multimineralsvia Pyrimethamine | Moderate | Absorption | INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its… | 2 sources — open the full entry |
| Carbonyl Iron + Folic Acidvia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Carbonyl Iron + Folic Acid + Zinc Sulfatevia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Carbonyl Iron + Folic Acid + Zinc Sulfate + Vitamin B Complex + Vitamin Cvia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Cyproterone Acetate + Ethinyl Estradiolvia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Dapsonevia Sulfadoxinematched approximately | Moderate | Synergy | Coadministration of oral or topical dapsone with other agents associated with methemoglobinemia may have additive effects and theoretically increase the risk… | 2 sources — open the full entry |
| Dienogest + Estradiol Valeratevia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Diroximel Fumaratevia Sulfadoxinematched approximately | Moderate | Synergy | The use of fumaric acid esters in combination with medications that can cause nephrotoxicity (e.g., aminoglycosides, diuretics, nonsteroidal anti-inflammatory… | 7 sources — open the full entry |
| Drospirenone + Estradiolvia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol0.02 mg0.03 mgvia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol + Levomefolatevia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Efavirenzvia Sulfadoxine, Pyrimethaminematched approximately | Moderate | Synergy · Unknown | Coadministration of efavirenz with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. Efavirenz has been associated with…2 documented mechanisms | 7 sources — open the full entry |
| Epirubicin Hydrochloridevia Sulfadoxinematched approximately | Moderate | Synergy | The concomitant or sequential use of epirubicin with agents known to induce hepatotoxicity may potentiate the risk of liver injury. Epirubicin undergoes… | 4 sources — open the full entry |
| Estradiolbasevaginal creamvia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol + Dydrogesteronevia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol Hemihydrate + Progesterone Micronizedvia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol Valeratevia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Desogestrel0.02 mg0.03 mgvia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Gestodenevia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Levonorgestrel + Ferrous Fumaratevia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Lynestrenol0.0375 mg0.05 mgvia Sulfadoxinematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ferrous Ascorbate + Folic Acid + Zinc Sulfatevia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Ferrous Fumarate + Folic acidvia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Ferrous Sulfate + Folic Acidvia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Ferrous Sulfate + Folic Acid + Zinc Sulfatevia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Folic Acidvia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Folic Acid + Zinc Sulfate Monohydratevia Pyrimethamine, Sulfadoxinematched approximately | Moderate | Antagonism | Folate antagonists such as sulfonamides, triamterene, trimethoprim, or pyrimethamine may decrease folic acid serum concentration. The mechanism may be related…2 documented mechanisms | 22 sources — open the full entry |
| Fosphenytoin Sodiumvia Sulfadoxinematched approximately | Moderate | Others | Some sulfonamides may inhibit the hepatic metabolism of hydantoins. Serum hydantoin levels and risk of toxicity may be increased. Data are available for… | 18 sources — open the full entry |
| Glibenclamidevia Sulfadoxinematched approximately | Moderate | Synergy | The hypoglycemic effect of insulin secretagogues (e.g., sulfonylureas, meglitinides) may be potentiated by certain drugs, including ACE inhibitors… | 112 sources — open the full entry |
| Glimepiridevia Sulfadoxinematched approximately | Moderate | Synergy | The hypoglycemic effect of insulin secretagogues (e.g., sulfonylureas, meglitinides) may be potentiated by certain drugs, including ACE inhibitors… | 112 sources — open the full entry |
| Glimepiride + Metforminvia Sulfadoxinematched approximately | Moderate | Synergy | The hypoglycemic effect of insulin secretagogues (e.g., sulfonylureas, meglitinides) may be potentiated by certain drugs, including ACE inhibitors… | 112 sources — open the full entry |
| Glipizidevia Sulfadoxinematched approximately | Moderate | Synergy | The hypoglycemic effect of insulin secretagogues (e.g., sulfonylureas, meglitinides) may be potentiated by certain drugs, including ACE inhibitors… | 112 sources — open the full entry |
| Glipizide + Metformin Hydrochloridevia Sulfadoxinematched approximately | Moderate | Synergy | The hypoglycemic effect of insulin secretagogues (e.g., sulfonylureas, meglitinides) may be potentiated by certain drugs, including ACE inhibitors… | 112 sources — open the full entry |
Conditions
Conditions in which Sulphadoxine + Pyrimethamine needs care, as documented in this source.
Folic Acid Deficiency
MajorPyrimethamine is a folate antagonist. The use of pyrimethamine is contraindicated in patients with megaloblastic anemia caused by folate deficiency. Pyrimethamine should be used with caution in patients with malabsorption syndrome, alcoholism, pregnancy, and in those receiving other folate depleting drugs. Monitoring CBCs and platelet counts are recommended. If signs of folic acid deficiency occur, the drug dosage should be reduced or discontinued. Leucovorin may need to be administered to reverse folic acid deficiency.
1 source
- "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome (2001):
Epilepsy
ModerateThe use of pyrimethamine has been associated with ataxia, tremors, and seizures. Therapy with pyrimethamine should be administered cautiously and in lower dosages in patients with seizure disorders.
1 source
- "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome (2001):
Kidney Diseases
ModeratePyrimethamine and its metabolites are excreted in the urine. Therapy with pyrimethamine should be administered cautiously in patients with renal dysfunction.
1 source
- "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome (2001):
Liver Diseases
ModeratePyrimethamine is extensively metabolized by the liver. Therapy with pyrimethamine should be administered cautiously in patients with liver disease.
1 source
- "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome (2001):
Therapeutic duplication
Drug classes that overlap with Sulphadoxine + Pyrimethamine, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
antimalarials
The recommended maximum number of medicines in the 'antimalarials' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antimalarials' category.
Example product in the source data (US market): Coartem
antimalarials
The recommended maximum number of medicines in the 'antimalarials' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antimalarials' category.
Example product in the source data (US market): Malarone pediatric