Prucalopride Succinate interactions

Checked as Prucalopride in this data source.

Full monograph for Prucalopride Succinate Check it against another medicine

Medicines

97 documented

Severity

Mechanism

Medicines documented to interact with Prucalopride Succinate, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Aclidinium Bromide + Formoterol Fumarate	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Atropine Sulfate (Injection)	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Beclometasone + Formoterol + Glycopyrronium	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Budesonide + Glycopyrronium Bromide + Formoterol Fumarate	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Cinnarizine + Dimenhydrinate	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Cyclizine Hydrochloride	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Cyproterone Acetate + Ethinyl Estradiol	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Darifenacin	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Desogestrel	Moderate	Absorption	The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	3 sources — open the full entry
Dicycloverine Hydrochloride	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Dienogest	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.2 documented mechanisms	40 sources — open the full entry
Dienogest + Estradiol Valerate	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.2 documented mechanisms	40 sources — open the full entry
Diphenhydramine + Dextromethorphan + Levomenthol	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Diphenhydramine + Levomenthol	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Diphenhydramine Hydrochloride	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Diphenhydramine Hydrochloride + Zinc Acetate	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Drospirenone + Ethinyl Estradiol0.02 mg 0.03 mg	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Drospirenone + Ethinyl Estradiol + Levomefolate	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Elacestrant	Moderate	Absorption	Coadministration with elacestrant may increase the plasma concentrations of drugs that are substrates of P-glycoprotein (P-gp) and/or breast cancer resistance…	1 sources — open the full entry
Erdafitinib	Moderate	Distribution	Coadministration with erdafitinib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter…	1 sources — open the full entry
Ethinyl Estradiol + Desogestrel0.02 mg 0.03 mg	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.2 documented mechanisms	40 sources — open the full entry
Ethinyl Estradiol + Gestodene	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Ethinyl Estradiol + Levonorgestrel + Ferrous Fumarate	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.2 documented mechanisms	37 sources — open the full entry
Ethinyl Estradiol + Lynestrenol0.0375 mg 0.05 mg	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Fesoterodine Fumarate	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Flavoxate Hydrochloride	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Formoterol Fumarate + Glycopyrrolate + Budesonide	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Gilteritinib Fumarate	Moderate	Absorption	Coadministration with gilteritinib may increase the plasma concentrations and the risk of adverse effects of orally administered drugs that are substrates of…	3 sources — open the full entry
Glycopyrronium BromideInhalation capsule Injection Oral solution Respirator Solution	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Glycopyrronium Bromide + Formoterol Fumarate	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Guaifenesin + Levomenthol + Diphenhydramine	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Homatropine Hydrobromide	Moderate	Antagonism	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	2 sources — open the full entry
Hyoscine Butylbromide	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Hyoscine Hydrobromide	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Indacaterol + Glycopyrronium	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Indacaterol + Glycopyrronium + Mometasone Furoate	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Ipratropium Bromide	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Lasmiditan Hemisuccinate	Moderate	Distribution	Coadministration with lasmiditan may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) and/or breast cancer…	1 sources — open the full entry
Levonorgestrel [For emergency contraception]	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Meclizine + Pyridoxine	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Meclizine Hydrochloride	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Norethisterone Acetate	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Norgestrel + Ethinyl Estradiol + Ferrous Fumarate	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.2 documented mechanisms	37 sources — open the full entry
Norgestrel [For breastfeeding mother]	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Procyclidine Hydrochloride	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Propantheline Bromide	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Relugolix + Estradiol + Norethindrone	Moderate	Absorption	RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment.	37 sources — open the full entry
Revefenacin	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Salbutamol + IpratropiumInhaler Solution for inhalation	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry
Solifenacin Succinate	Moderate	Absorption	Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility…	6 sources — open the full entry

Conditions

Conditions in which Prucalopride Succinate needs care, as documented in this source.

Inflammatory Bowel Diseases
Major
The use of prucalopride is contraindicated in patients with severe inflammatory conditions of the intestinal tract such as Crohn's disease, ulcerative colitis, and toxic megacolon/megarectum.
1 source
1. "Product Information. Resotran (prucalopride)." Janssen Pharmaceuticals (2012):
Intestinal Perforation
Major
The use of prucalopride is contraindicated in patients with obstructive ileus, and intestinal perforation or obstruction due to structural or functional disorder of the gut wall.
1 source
1. "Product Information. Resotran (prucalopride)." Janssen Pharmaceuticals (2012):
Kidney Diseases
Major
Prucalopride is known to be substantially excreted by the kidney, and the risk of adverse reactions may be greater in patients with impaired renal function. No dosage adjustment is required for patients with mild and moderate renal impairment. A decreased dosage is recommended in patients with severe renal impairment. Avoid the use of prucalopride in patients with end-stage renal disease requiring dialysis.
1 source
1. "Product Information. Resotran (prucalopride)." Janssen Pharmaceuticals (2012):
Depressive Disorder
Moderate
Suicides, suicide attempts, and suicidal ideation have been reported with the use of prucalopride. It is recommended to monitor all patients for persistent worsening of depression or the emergence of suicidal thoughts and behaviors. Patients should discontinue prucalopride immediately if they experience any of these symptoms.
1 source
1. "Product Information. Resotran (prucalopride)." Janssen Pharmaceuticals (2012):

Medicines

Conditions

Inflammatory Bowel Diseases

Intestinal Perforation

Kidney Diseases

Depressive Disorder