Sodium Bicarbonate interactions

Full monograph for Sodium Bicarbonate Check it against another medicine

Medicines

459 documented

Severity

Mechanism

Medicines documented to interact with Sodium Bicarbonate, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Selpercatinib	Major	Absorption	Coadministration with drugs that increase gastric pH may significantly decrease the oral bioavailability of selpercatinib and reduce its concentrations in…	2 sources — open the full entry
Sotorasib	Major	Absorption	Coadministration with drugs that increase gastric pH may significantly decrease the oral bioavailability of sotorasib and reduce its concentrations in plasma.	2 sources — open the full entry
Acalabrutinib	Moderate	Absorption	INTERVAL: Coadministration with drugs that increase gastric pH may significantly decrease the oral bioavailability of acalabrutinib and reduce its…	2 sources — open the full entry
Aspirin	Moderate	Excretion	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…	5 sources — open the full entry
Aspirin + Dipyridamole	Moderate	Excretion · Unknown	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…2 documented mechanisms	5 sources — open the full entry
Atropine Sulfate (Injection)	Moderate	Absorption	INTERVAL: Concurrent administration of antacids or adsorbent antidiarrheal agents may decrease the oral bioavailability of atropine.	1 sources — open the full entry
Benzoic Acid + Salicylic Acid	Moderate	Excretion	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…	5 sources — open the full entry
Betamethasone Dipropionate + Salicylic Acid	Moderate	Absorption · Excretion	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…2 documented mechanisms	8 sources — open the full entry
Bisacodyl	Moderate	Absorption	INTERVAL: By increasing gastric pH, antacids may reduce the resistance of the enteric coating of bisacodyl tablets, resulting in earlier release of bisacodyl…	1 sources — open the full entry
Carbonyl Iron + Folic Acid	Moderate	Absorption · Unknown	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Carbonyl Iron + Folic Acid + Zinc Sulfate	Moderate	Absorption · Unknown	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Carbonyl Iron + Folic Acid + Zinc Sulfate + Vitamin B Complex + Vitamin C	Moderate	Absorption · Unknown	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Cefditoren	Moderate	Absorption	Coadministration with antacids or agents with acid-neutralizing effects may reduce the oral absorption and plasma concentrations of cefditoren pivoxil.	2 sources — open the full entry
Cefpodoxime Proxetil	Moderate	Absorption	INTERVAL: Coadministration with antacids or agents with acid-neutralizing effects may reduce the oral bioavailability of cefpodoxime proxetil and cefuroxime…	4 sources — open the full entry
Cefpodoxime Proxetil + Clavulanic Acid	Moderate	Absorption	INTERVAL: Coadministration with antacids or agents with acid-neutralizing effects may reduce the oral bioavailability of cefpodoxime proxetil and cefuroxime…	4 sources — open the full entry
Cefuroxime Axetil	Moderate	Absorption	INTERVAL: Coadministration with antacids or agents with acid-neutralizing effects may reduce the oral bioavailability of cefpodoxime proxetil and cefuroxime…	4 sources — open the full entry
Cefuroxime Axetil + Clavulanic Acid	Moderate	Absorption	INTERVAL: Coadministration with antacids or agents with acid-neutralizing effects may reduce the oral bioavailability of cefpodoxime proxetil and cefuroxime…	4 sources — open the full entry
Ceritinib	Moderate	Absorption	Drugs that alter the pH of the upper gastrointestinal tract may affect the solubility of ceritinib and reduce its bioavailability. The interaction has not been…	2 sources — open the full entry
Cetalkonium Chloride + Choline Salicylate	Moderate	Excretion	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…	5 sources — open the full entry
Ciprofloxacinbase Ophthalmic	Moderate	Excretion	Urinary alkalinizers such as citrates may decrease the solubility of fluoroquinolones in the urine and increase the risk of crystalluria.	2 sources — open the full entry
Ciprofloxacin + Dexamethasone	Moderate	Absorption · Excretion	Urinary alkalinizers such as citrates may decrease the solubility of fluoroquinolones in the urine and increase the risk of crystalluria.2 documented mechanisms	5 sources — open the full entry
Ciprofloxacin + Hydrocortisone Acetate	Moderate	Excretion	Urinary alkalinizers such as citrates may decrease the solubility of fluoroquinolones in the urine and increase the risk of crystalluria.	2 sources — open the full entry
Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafine	Moderate	Excretion	Urinary alkalinizers such as citrates may decrease the solubility of fluoroquinolones in the urine and increase the risk of crystalluria.	2 sources — open the full entry
Clobetasol Propionate + Salicylic Acid	Moderate	Excretion	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…	5 sources — open the full entry
Clopidogrel + Aspirin	Moderate	Excretion · Unknown	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…2 documented mechanisms	5 sources — open the full entry
Coal Tar + Precipitated Sulphur + Salicylic Acid	Moderate	Excretion	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…	5 sources — open the full entry
Dabigatran Etexilate Mesylate	Moderate	Absorption	Coadministration with an antacid may reduce the bioavailability of dabigatran following oral administration of dabigatran etexilate.	1 sources — open the full entry
Dasatinib	Moderate	Absorption	INTERVAL: Nonclinical data indicate that the solubility of dasatinib is pH-dependent. Therefore, coadministration with antacids or agents with…	4 sources — open the full entry
Dexamethasone + Levofloxacin	Moderate	Absorption · Excretion	Urinary alkalinizers such as citrates may decrease the solubility of fluoroquinolones in the urine and increase the risk of crystalluria.2 documented mechanisms	5 sources — open the full entry
Dextromethorphan + Pseudoephedrine + Triprolidine	Moderate	Excretion	Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. Toxicity from…	3 sources — open the full entry
Dithranol + Boric Acid + Salicylic Acid	Moderate	Excretion	Agents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin or other…	5 sources — open the full entry
Doxycycline Hydrochloride	Moderate	Excretion	INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve…	5 sources — open the full entry
Ephedrine Hydrochloride	Moderate	Excretion	Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. Toxicity from…	3 sources — open the full entry
Erlotinib	Moderate	Absorption	INTERVAL: Concurrent administration of antacids or other agents with acid-neutralizing effects may decrease the oral bioavailability of erlotinib and reduce…	6 sources — open the full entry
Ethinyl Estradiol + Levonorgestrel + Ferrous Fumarate	Moderate	Absorption	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…	12 sources — open the full entry
Ferric Maltol	Moderate	Absorption	The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The…	12 sources — open the full entry
Ferrous Fumarate + Folic acid	Moderate	Absorption · Unknown	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Gatifloxacin	Moderate	Excretion	Urinary alkalinizers such as citrates may decrease the solubility of fluoroquinolones in the urine and increase the risk of crystalluria.	2 sources — open the full entry
Gatifloxacin + Dexamethasone	Moderate	Absorption · Excretion	Urinary alkalinizers such as citrates may decrease the solubility of fluoroquinolones in the urine and increase the risk of crystalluria.2 documented mechanisms	5 sources — open the full entry
Glibenclamide	Moderate	Absorption	INTERVAL: Some antacids have been reported to increase the rate of absorption and, rarely, the extent of absorption of oral sulfonylureas. The hypoglycemic…	17 sources — open the full entry
Glipizide	Moderate	Absorption	INTERVAL: Some antacids have been reported to increase the rate of absorption and, rarely, the extent of absorption of oral sulfonylureas. The hypoglycemic…	17 sources — open the full entry
Glipizide + Metformin Hydrochloride	Moderate	Absorption · Unknown	INTERVAL: Some antacids have been reported to increase the rate of absorption and, rarely, the extent of absorption of oral sulfonylureas. The hypoglycemic…2 documented mechanisms	17 sources — open the full entry
Iron + Folic Acid + Vitamin A + Vitamin C + Zinc	Moderate	Absorption · Unknown	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Iron + Folic acid + Vitamin B complex + Vitamin C	Moderate	Absorption · Unknown	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Iron + Folic Acid + Vitamin B Complex + Vitamine C + Zinc Sulfate	Moderate	Absorption · Unknown	INTERVAL: The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing…2 documented mechanisms	12 sources — open the full entry
Iron Polymaltose Complex	Moderate	Absorption	The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The…	12 sources — open the full entry
Iron Polymaltose Complex + Folic Acid + Zinc + Vitamin B-Complex	Moderate	Absorption · Unknown	The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The…2 documented mechanisms	12 sources — open the full entry
Iron Polymaltose Complex + Folic Acid + Zinc Sulfate	Moderate	Absorption · Unknown	The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The…2 documented mechanisms	12 sources — open the full entry
Iron Polymaltose Complex + Vitamin B Complex + Zinc	Moderate	Absorption	The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The…	12 sources — open the full entry
Itraconazole	Moderate	Absorption	INTERVAL: The dissolution of itraconazole requires an acidic environment. Antacids and some aluminum, calcium, or magnesium containing salts decrease the…	15 sources — open the full entry

Conditions

Conditions in which Sodium Bicarbonate needs care, as documented in this source.

Water-Electrolyte Imbalance
Major
Alkalinizing agents containing sodium can induce sodium and water retention and result in hypernatremia, hypokalemia, hyperosmolality, edema and aggravation of congestive heart failure. Therapy with sodium- containing alkalinizing agents should not be used in patients with hypernatremia or fluid retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with alkalinizing agents is recommended.
2 sources
1. "Product Information. Sodium Bicarbonate (sodium bicarbonate)." Astra-Zeneca Pharmaceuticals (2001):
2. "Product Information. Sodium Lactate (sodium lactate)." Abbott Pharmaceutical (2001):
Acid-Base Imbalance
Moderate
Alkalinizing agents act as proton acceptors and/or dissociate to provide bicarbonate ions. Elimination of bicarbonate is decreased in patients with renal impairment and can result in metabolic alkalosis. Symptoms of metabolic alkalosis include hyperirritability or tetany, arrhythmia, and/or seizures (altered pH = altered calcium), or lactic acidosis due to impaired oxygen release. Therapy with alkalinizing agents should be administered with extreme caution in patients with compromised renal function. Clinical monitoring of renal function, acid/base balance and electrolytes is recommended.
3 sources
1. "Product Information. Urocit-K (potassium citrate)." Mission Pharmacal Company
2. "Product Information. Tham (tromethamine)." Abbott Pharmaceutical (2001):
3. "Product Information. Sodium Lactate (sodium lactate)." Abbott Pharmaceutical (2001):

Medicines

Conditions

Water-Electrolyte Imbalance

Acid-Base Imbalance