Acitretin interactions

Food & lifestyle

• alcohol

  Major

  Synergy

  Ethanol consumption with acitretin leads to the formation of etretinate, which has a much longer half-life than acitretin. Major human fetal abnormalities have been associated with the administration of acitretin, etretinate, and other retinoids.

  What to do: Female patients should be warned that ethanol is contraindicated during active treatment with acitretin and for two months after cessation of therapy.

  1 source

  1. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):

Conditions

Conditions in which Acitretin needs care, as documented in this source.

• Hyperlipidemias

  Major

  Acitretin is contraindicated in patients with chronic abnormally elevated blood lipid values. It is recommended to evaluate lipid status in patients before initiation of therapy and periodically until the lipid response to the drug is established. Care should be taken in subjects with an increased tendency to develop hypertriglyceridemia included those with disturbances of lipid metabolism, obesity, or a familial history of these conditions. Serum lipids must be more closely monitored in high-risk patients and during long-term treatment with acitretin. Dietary modifications, reduction in dose of acitretin, or drug therapy should be employed to control significant elevations of triglycerides, and if hypertriglyceridemia and low HDL levels persist, discontinuation of acitretin should be considered.

  1 source

  1. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):

• Intracranial Hypertension

  Major

  The use of retinoids has been associated with cases of pseudotumor cerebri (benign intracranial hypertension). Early signs and symptoms include papilledema, headache, nausea and vomiting, and visual disturbances. Patients who experience symptoms of this disorder while on retinoid therapy should be referred to a neurologist. If the diagnosis is confirmed, the retinoid should be discontinued permanently.

  2 sources

  1. "Product Information. Accutane (isotretinoin)." Roche Laboratories (2001):
  2. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):

• Kidney Diseases

  Major

  The use of acitretin has been associated with significant lower plasma concentrations in patients with end-stage renal failure. Therapy with acitretin is contraindicated in patients with severely impaired kidney function. It is recommended to monitor renal function as per clinical guidelines. Acitretin is not removed by hemodialysis.

  1 source

  1. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):

• Liver Diseases

  Major

  The use of retinoids has been associated with elevations in liver enzymes and toxic hepatitis. Therapy with acitretin is contraindicated in patients with severely impaired liver function.

  1 source

  1. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):

• Mental Disorders

  Major

  The use of retinoids, primarily isotretinoin, has been associated with causing depression, psychosis and rarely, suicidal ideation. Therapy with retinoids should be administered cautiously in patients with preexisting psychiatric conditions or depression. In addition to withdrawal of therapy, evaluation and follow-up may be necessary in affected patients.

  2 sources

  1. "Product Information. Accutane (isotretinoin)." Roche Laboratories (2001):
  2. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):

• Alcoholism

  Moderate

  Like other retinoids, acitretin is a teratogen. The concurrent use of alcohol and acitretin has been associated with the formation of etretinate, a related retinoid drug with a considerably longer half-life (mean: 120 days vs. 49 hours). Alcohol should be avoided during acitretin therapy and for two months after completion of therapy in female patients of child-bearing age, since it may prolong the duration of teratogenic potential of the drug.

  1 source

  1. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):

• Diabetes Mellitus

  Moderate

  The use of acitretin may adversely affect blood sugar levels and result in problems with blood sugar control. In addition, new cases of diabetes have been diagnosed during retinoid therapy, including diabetic ketoacidosis. It is recommended to monitor blood sugar levels very closely in diabetic patients.

  1 source

  1. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):

• Toxic Optic Neuropathy

  Moderate

  Ophthalmologic manifestations have been reported with the use of acitretin. It is recommended that any patient treated with acitretin who is experiencing visual difficulties should discontinue the drug and undergo ophthalmologic evaluation.

  1 source

  1. "Product Information. Soriatane (acitretin)." Roche Laboratories (2001):